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Developmental Cancer Therapeutics (DCT) Bookmark and Share

Developmental Cancer Therapeutics Program

Karen Aboody, M.D., Co-leader
Edward Newman, Ph.D., Co-leader
Program Members - If you would like an updated membership list, please contact Kim Lu at kilu@coh.org.
 
The long-term goal of the Developmental Cancer Therapeutics (DCT) Program is to develop more effective and less toxic treatments for cancer. This multidisciplinary program spans basic, translational and clinical research by fostering close collaborations among basic and clinical researchers. While the program continues its long-standing strength in evaluating cancer therapeutics developed by collaborators at other academic institutions and the pharmaceutical industry, the major emphasis of this program moving forward is on the development of novel, molecularly-targeted cancer therapeutics at City of Hope .
 
Our mission is not to compete with the pharmaceutical industry, but rather to complement cancer drug development and partner with the industry for the ultimate purpose of bringing innovative cancer therapies into the clinic.
 
Our major focus is on:

(a) unique molecular targets that may not be high priorities for the pharmaceutical industry,
(b) natural products screening and synthesis of natural product derivatives and
(c) matching targeted therapies with appropriate molecular subtypes of tumors.
 
Program Goals
  • To identify and validate new molecular targets for innovative cancer therapy approaches
  • To select and develop novel small-molecule inhibitors of promising molecular targets
  • To investigate molecular and pharmacologic mechanisms of drug action and drug delivery
  • To translate basic and preclinical studies into early phase clinical trials for treatment of cancer
 
DCT Members' Research
Members of the DCT Program have expertise in a wide spectrum of disciplines essential for development of innovative, molecularly-targeted cancer therapeutics. These include molecular target identification by gene expression profiling, target validation by RNAi approaches, lead compound selection by computational and high-throughput screening approaches, total synthesis of natural products and their derivatives, structure-activity relationships, combinatorial chemistry, pharmacokinetics and pharmacodynamics, and phase I and II clinical trials. This broad range of highly-specialized areas of expertise is focused on a concerted effort to develop new cancer therapeutics, from target identification through drug development to clinical trials.
 

Developmental Cancer Therapeutics (DCT)

Developmental Cancer Therapeutics Program

Karen Aboody, M.D., Co-leader
Edward Newman, Ph.D., Co-leader
Program Members - If you would like an updated membership list, please contact Kim Lu at kilu@coh.org.
 
The long-term goal of the Developmental Cancer Therapeutics (DCT) Program is to develop more effective and less toxic treatments for cancer. This multidisciplinary program spans basic, translational and clinical research by fostering close collaborations among basic and clinical researchers. While the program continues its long-standing strength in evaluating cancer therapeutics developed by collaborators at other academic institutions and the pharmaceutical industry, the major emphasis of this program moving forward is on the development of novel, molecularly-targeted cancer therapeutics at City of Hope .
 
Our mission is not to compete with the pharmaceutical industry, but rather to complement cancer drug development and partner with the industry for the ultimate purpose of bringing innovative cancer therapies into the clinic.
 
Our major focus is on:

(a) unique molecular targets that may not be high priorities for the pharmaceutical industry,
(b) natural products screening and synthesis of natural product derivatives and
(c) matching targeted therapies with appropriate molecular subtypes of tumors.
 
Program Goals
  • To identify and validate new molecular targets for innovative cancer therapy approaches
  • To select and develop novel small-molecule inhibitors of promising molecular targets
  • To investigate molecular and pharmacologic mechanisms of drug action and drug delivery
  • To translate basic and preclinical studies into early phase clinical trials for treatment of cancer
 
DCT Members' Research
Members of the DCT Program have expertise in a wide spectrum of disciplines essential for development of innovative, molecularly-targeted cancer therapeutics. These include molecular target identification by gene expression profiling, target validation by RNAi approaches, lead compound selection by computational and high-throughput screening approaches, total synthesis of natural products and their derivatives, structure-activity relationships, combinatorial chemistry, pharmacokinetics and pharmacodynamics, and phase I and II clinical trials. This broad range of highly-specialized areas of expertise is focused on a concerted effort to develop new cancer therapeutics, from target identification through drug development to clinical trials.
 
Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Clinical Trials
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials.
 
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
Discover the wide range of progressive cancer treatment options at City of Hope designed to meet the individual needs of each patient. Here, medical research and clinical care are integrated, speeding the application of scientific discoveries toward better, more effective patient cancer treatments.
City of Hope Breakthroughs
Get the latest in City of Hope's research, treatment and news you can use on our blog, Breakthroughs.
 
 
When you support City of Hope, you help us shorten the time it takes to get from bold, innovative ideas to powerful new medical treatments. Make a gift online now.
NEWS & UPDATES
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  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free. In his first post, ...
  • Advanced age tops the list among breast cancer risk factor for women. Not far behind is family history and genetics. Two City of Hope researchers delving deep into these issues recently received important grants to advance their studies. Arti Hurria, M.D., director of the Cancer and Aging Research Program, and ...
  • City of Hope is extending the reach of its lifesaving mission well beyond U.S. borders. To that end, three distinguished City of Hope leaders visited China earlier this year to lay the foundation for the institution’s new International Medicine Program. The program is part of City of Hope’s strategi...
  • A hallmark of cancer is that it doesn’t always limit itself to a primary location. It spreads. Breast cancer and lung cancer in particular are prone to spread, or metastasize, to the brain. Often the brain metastasis isn’t discovered until years after the initial diagnosis, just when patients were beginning to ...
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  • Most women who are treated for breast cancer with a mastectomy do not choose to undergo reconstructive surgery. The reasons for this, according to a recent JAMA Surgery study, vary. Nearly half say they do not want any additional surgery, while nearly 34 percent say breast cancer reconstruction simply isn’t imp...
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  • First, the good news: HIV infections have dropped dramatically over the past 30 years. Doctors, researchers and health officials have made great strides in preventing and treating the disease, turning what was once a death sentence into, for some, a chronic condition. Now, the reality check: HIV is still a worl...
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  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free.   In his previ...