A National Cancer Institute-designated Comprehensive Cancer Center

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Stem Cell and Leukemia Research

The focus of the Division of Hematopoietic Stem Cell and Leukemia Research is to improve the understanding of leukemia stem cells in order to develop cures for leukemia and other hematologic malignancies. Leukemia stem cells and progenitor cells differ significantly from mature leukemia cells and, of course, from normal hematopoietic stem cells. Because recent studies have demonstrated that leukemia stem cells actually cause leukemia, the objective must now be to eradicate leukemia stem cells, rather than just the regular, mature leukemia cells addressed by current therapies. Eradication of the leukemia stem cells may actually produce cures.
 
Our goal is to investigate mechanisms of regulation of normal hematopoietic stem cell growth by the marrow microenvironment; the cellular and molecular mechanisms underlying stem cell transformation in patients with leukemias; assessment of the effects of therapeutic interventions on malignant stem cells; and preclinical and clinical development of innovative, mechanism-based therapeutic interventions directed against malignant stem cells.
 
Ravi Bhatia, M.D., is the director of this division and is actively recruiting additional basic and translational investigators. Takahiro Maeda, M.D., Ph.D., from Memorial Sloan Kettering Cancer Center joined the department in January 2007. Ya-Huei Kuo, Ph.D., from the University of Massachusetts Medical School joined the department in January 2008. Ching-Cheng Chen, Ph.D., from Stanford University joined the department in January of 2010.
 

Stem Cell and Leukemia Research Faculty and Staff

Stem Cell & Leukemia Research

Stem Cell and Leukemia Research

The focus of the Division of Hematopoietic Stem Cell and Leukemia Research is to improve the understanding of leukemia stem cells in order to develop cures for leukemia and other hematologic malignancies. Leukemia stem cells and progenitor cells differ significantly from mature leukemia cells and, of course, from normal hematopoietic stem cells. Because recent studies have demonstrated that leukemia stem cells actually cause leukemia, the objective must now be to eradicate leukemia stem cells, rather than just the regular, mature leukemia cells addressed by current therapies. Eradication of the leukemia stem cells may actually produce cures.
 
Our goal is to investigate mechanisms of regulation of normal hematopoietic stem cell growth by the marrow microenvironment; the cellular and molecular mechanisms underlying stem cell transformation in patients with leukemias; assessment of the effects of therapeutic interventions on malignant stem cells; and preclinical and clinical development of innovative, mechanism-based therapeutic interventions directed against malignant stem cells.
 
Ravi Bhatia, M.D., is the director of this division and is actively recruiting additional basic and translational investigators. Takahiro Maeda, M.D., Ph.D., from Memorial Sloan Kettering Cancer Center joined the department in January 2007. Ya-Huei Kuo, Ph.D., from the University of Massachusetts Medical School joined the department in January 2008. Ching-Cheng Chen, Ph.D., from Stanford University joined the department in January of 2010.
 

Faculty

Stem Cell and Leukemia Research Faculty and Staff

Research Overview
Research pioneered at City of Hope has improved the lives of men, women and children throughout the world.
 
Beckman Research Institute

Beckman Research Institute of City of Hope is internationally  recognized for its innovative translational biomedical research.
 

Comprehensive Cancer Center
City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and education.

Our Scientists

Our research laboratories are led by the best and brightest minds in scientific research.
 

Technology & Licensing
The Center for Applied Technology Development offers broad expertise in
technology transfer and licensing, biologics manufacturing, quality assurance and regulatory affairs.

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

NEWS & UPDATES
  • Although a stem cell transplant can be a lifesaving procedure for people diagnosed with a blood cancer or blood disorder, the standard transplant may not be appropriate for all patients. This is because the conditioning regimen (the intensive chemotherapy and/or radiation treatments preceding the transplant) is...
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  • Nearly four decades ago, City of Hope began its bone marrow transplant program. Its first transplant reunion celebration was a single patient and his donor, also his brother. This year, City of Hope welcomed hundreds of hematopoietic cell transplant (HCT) recipients to the annual bone marrow transplant/HCT reun...
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  • Christine Crews isn’t only a fitness enthusiast, she’s also a personal trainer and fitness instructor. Being active defines her life. So when she was diagnosed with bladder cancer at age 30, she decided she absolutely couldn’t let the disease interfere with that lifestyle. And it didn’t. For t...
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  • Thanks to the California Institute for Regenerative Medicine (CIRM), high school students across the state gained valuable hands-on experience with stem cell research this summer. City of Hope hosted eight of those students. As part of the CIRM Creativity Awards program, the young scholars worked full time as m...
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