Quality Control

The efficient output of high-quality materials by the Synthetic and Biopolymer Chemistry Core (SBCC) is second to none. The high caliber of scientific core staff members and years of experience ensures efficiency, accuracy, and product reliability. The SBCC is in a unique position to fulfill not only “routine” requests but also deliver novel and custom chemical entities. All materials undergo the utmost stringent purification and structural characterization protocols to ensure high purity and identification. For small molecule work, all compounds are subjected to extensive nuclear magnetic resonance and mass spectroscopy characterization as well as infrared, ultraviolet and combustion analyses. Investigators also receive valuable design and execution input from the SBCC scientists. These discussions often result in the development of better alternatives that are significantly different from the original approach.
 
The Synthetic and Biopolymer Chemistry Core has implemented a series of informatics programs and standard operating procedures (SOP) to ensure proper management of information and data it handles regularly. These steps will also allow for efficient information exchange between the core, its users as well as other Cancer Center cores and shared resources on campus.
 
  • LIMS: The SBCC has in place a comprehensive centralized database, built upon a Laboratory Information Management System (LIMS).
 
  • Information Tracking: eNotebook records daily experiments
 
  • Compound Registration: All compounds including biopolymers, regardless of source, are entered into the database and assigned a unique ID #. The unique ID# facilitates tracking of the compound as it passes through various reactions, assays, and analysis. In addition, chemical properties, source (including link to eNotebook) and structural data are linked to the ID # and are readily accessible.
 
  • Barcoding: Reagents and chemicals have barcode identification for inventory purposes that greatly facilitates ETS compliance.
 
  • Quality Control: All spectral data such as 1H and 13C NMR, mass spec, IR, UV, and HPLC traces are stringently analyzed and deposited in the LIMS for each completed and approved compound.