Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Don and Lois Hoffman
Breast Cancer: 'It's supposed to be a woman's disease'

June 15, 2016 | Stephanie Smith

Male breast cancer is unusual. Breast cancer being cast as “a woman’s disease” means men aren’t checking for it and therefore tend to be diagnosed later. Despite the paltry number of cases, being vigilant is important for men - a lesson Don Hoffman learned the hard way.

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Veliparib molecular formula
Biomarker linked to survival and treatment for BRCA-positive breast cancer patients

June 8, 2016 | H. Chung So

For breast cancer patients with BRCA gene mutations, compounds called poly ADP ribose (or PAR) can help determine treatment response and clinical outcomes.

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breast cancer genetic testing
Breast cancer genetic testing: How one family took control

January 5, 2015 | Nicole White

Betsy Sauer and her four daughters share plenty in common. They’re smart and successful.  They’re funny, ranging from wryly witty to wickedly hilarious. Their hobbies tend toward the active and adventurous: hiking, rock climbing, skiing, swimming, fishing, kayaking, yoga and horseback riding.

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Genes and cancer risk
Cancer in your family history? Your genes are not your destiny

November 21, 2014 | Valerie Zapanta

When it comes to cancer, your family history may provide more questions than answers: How do my genes increase my risk for cancer? No one in my family has had cancer; does that mean I won’t get cancer? What cancers are common in certain populations and ethnicities? City of Hope experts have some guidance.

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Cancer and genes
What are my genes telling me about my cancer risk?

October 27, 2014 | Valerie Zapanta

Genetics, genes, genome, genetic risk ... Such terms are becoming increasingly familiar to even nonresearchers as studies and information about the human make-up become more extensive and more critical.

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Breast cancer risk: 6 things you can do to reduce (not eliminate) risk

October 14, 2014 | Nicole White

The leading risk factor for breast cancer is simply being a woman. The second top risk factor is getting older. Many breast cancer risk factors, such as gender and aging, cannot be controlled. But lacing up for a walk a few times a week can put a dent in breast cancer risk.

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Parp1
ASCO 2014: Experimental drug has potential for BRCA-linked breast cancer

May 26, 2014 | Hiu Chung So

For patients with BRCA mutation-associated breast cancer, the experimental drug ABT-888 — also known as veliparib — is showing promise as a treatment, according to phase II clinical trial results that will be reported at the upcoming annual meeting of the American Society of Clinical Oncology.

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Eva Moon
'Mutant Diaries' resonates among women with BRCA genetic mutations

October 28, 2013 | Tami Dennis

"How far would you go to save your life?" That's the question faced by women who find they're carriers of the BRCA genetic mutations, which dramatically increase their risk of breast and ovarian cancer.

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Latinas and breast cancer: Researcher's genetic work gets a boost

October 2, 2013 | Nicole White

Most breast cancers are not genetic, but for women who carry a BRCA mutation, their risk of developing breast cancer can be as high as 85 percent over their lifetime. City of Hope researchers received $380,000 to study breast cancer mutations that affect Latinas.

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Supreme Court ruling on gene patents sets precedent, experts say

June 17, 2013 | Hiu Chung So

Months after hearing the arguments and weeks before concluding its current session, the Supreme Court unanimously ruled that human genes are a product of nature and are not patentable. On June 13, the Supreme Court ruled that human genes are not patentable, thus allowing other companies to test for BRCA gene mutations at a fraction of the current price.

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