City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.
March 17, 2017 | Denise Heady
Dual-trained pediatric oncologist and scientist Leo Wang, M.D., Ph.D., is working in the lab to understand how blood cells develop and grow, and plans to use that information to help patients with cancer live longer and experience fewer side effects of treatment.
January 27, 2017 | Denise Heady
City of Hope researchers have seen initial success treating brain cancer patients with CAR-T cell therapy, yet questions still linger about what exactly happens to these cells once they disperse through the brain. A new imaging technique may be the answer.
January 4, 2017 | Stephanie Smith
Sketches of a brain surgery performed on B., one of several patients in a breakthrough clinical trial for brain cancer at City of Hope. Early results of the trial — describing promising results using CAR-T cells for a 50-year-old patient with an aggressive brain cancer called glioblastoma multiforme — were published recently in the New England Journal of Medicine.
December 30, 2016 | Stephanie Smith
When viewed under a microscope, T cells - sentinels of the immune system whose job inside the body is to seek out foreign invaders - quiver as they surround and consume cancer cells. They were genetically modified in a lab by City of Hope researchers and trained to target specific receptors on patients’ brain tumors - part of an emerging approach to cancer care called immunotherapy.
December 29, 2016 | Denise Heady
City of Hope researchers have found that using CAR-T therapy, a type of immunotherapy, can be effective in the treatment of glioblastoma — one of the most aggressive brain tumors known to medicine.
December 14, 2016 | Denise Heady
One of but a few centers in the United States offering human studies in CAR–T cell therapy, City of Hope is the only center investigating CAR-T cells in injection form administered directly to brain tumors.
December 14, 2016 | City of Hope
City of Hope has the clinical and scientific expertise to house the entire clinical trial process on its campus — including collecting the cells, manufacturing the lentivirus, modifying and replicating the cells and reinfusing them.
October 18, 2016 | City of Hope
We worked with Steve Spangler of Sick! Science to visualize and better understand the science of immunotherapy being done at City of Hope. Learn how to use slime to represent the body’s immune system and a magnet to represent cancer.
October 17, 2016 | Denise Heady
Graduate student Dongrui Wang’s poster presentation at the 19th annual American Society of Gene & Cell Therapy was selected as the conference’s Outstanding Poster Presentation for his research initiatives in gene and cell therapy. Here Wang talks about what motivated him to pursue a career in science, what keeps him inspired and the innovative research he is working on at City of Hope.