Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

CAR T Illuminated
CAR-T cells: ‘Soldiers of the Immune System’

July 10, 2017 | Stephanie Smith

When viewed under a microscope, T cells - sentinels of the immune system whose job inside the body is to seek out foreign invaders - quiver as they surround and consume cancer cells. They were genetically modified in a lab by City of Hope researchers and trained to target specific receptors on patients’ brain tumors - part of an emerging approach to cancer care called immunotherapy.

Continue Reading

Inside CAR T 256 x 256
Inside CAR-T Cell Brain Surgery

January 4, 2017 | Stephanie Smith

Sketches of a brain surgery performed on B., one of several patients in a breakthrough clinical trial for brain cancer at City of Hope. Early results of the trial — describing promising results using CAR-T cells for a 50-year-old patient with an aggressive brain cancer called glioblastoma multiforme — were published recently in the New England Journal of Medicine.

Continue Reading

Breakthroughs - Dongrui Wang
Graduate student spotlight: Dongrui Wang and cancer immunotherapy

October 17, 2016 | Denise Heady

Graduate student Dongrui Wang’s poster presentation at the 19th annual American Society of Gene & Cell Therapy was selected as the conference’s Outstanding Poster Presentation for his research initiatives in gene and cell therapy. Here Wang talks about what motivated him to pursue a career in science, what keeps him inspired and the innovative research he is working on at City of Hope.

Continue Reading

Hope Experiment landing page lock up
Meet City of Hope's next generation of scientists: John P. Murad

September 13, 2016 | Jay Fernandez

One of the great benefits of medical breakthroughs is their potential for drawing great new curious minds to the field of medical science. One of those minds includes John P. Murad, a third-year graduate student working on a doctorate in biological sciences with an emphasis on cancer immunology and immune-based therapeutics.

Continue Reading

Christine Brown Bio Portrait
Inside the lab: Training your immune system to fight cancer

July 11, 2016 | Denise Heady

Soon, brain cancer will be treated differently. Just ask scientist Christine Brown, Ph.D., associate director of the T Cell Immunotherapy Laboratory at City of Hope. Brown is on the forefront of a specific kind of immunotherapy: CAR-T cell therapy. Here, Brown tells us how this type of therapy works and what it could mean for future treatment.

Continue Reading

Sumanta Pal 256x256
Cancer insights: 5 Tips for Vice President Joe Biden

January 19, 2016 | Sumanta Kumar Pal, M.D.

The recent state of the union address underscored a plan from the White House to lead a “moon shot” program – a massive effort to invest in cancer research with the ultimate goal of eradicating the disease. In order to reach this goal, while the amount of investment is critical, so too is the way in which funds are applied.

Continue Reading

Breakthroughs - brain cancer research
New funding for CAR-T cell study gives brain cancer research a boost

October 26, 2015 | City of Hope

Brain cancer is one of the toughest foes a doctor can face. It’s a tenacious form of cancer, inoperable in some cases and lethal in many. But at City of Hope, researchers are exploring new ways to conquer the most serious types of brain tumors in a clinical trial that deploys a patient’s own modified T cells to target cancer at the tumor site.

Continue Reading

pediatric cancer treatment
As CAR-T immunotherapy grows, pediatric cancer patients could benefit

September 16, 2015 | Mandy Qualls

Acute lymphoblastic leukemia is the most common type of childhood cancer, accounting for about 30 percent of all pediatric cancers.

Continue Reading

immunotherapy
New clinical trial harnesses CAR-T immunotherapy to fight brain cancers

June 29, 2015 | City of Hope

Already pioneers in the use of immunotherapy, City of Hope researchers are now testing the bold approach to cancer treatment against one of medicine’s biggest challenges: brain cancer. This month, they will launch a clinical trial using patients’ own modified T cells to fight advanced brain tumors.

Continue Reading

Larry Kwak
Physician researcher Larry Kwak's passion? Moving discoveries to clinic

May 1, 2015 | City of Hope

Renowned physician researcher Larry Kwak takes the helm of City of Hope's new Toni Stephenson Lymphoma Center. Known for his ability to bring together, and lead, effective research teams, world-renowned translational research scientist and physician Larry W.

Continue Reading

Load More
Back To Top