City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.
July 10, 2017 | Stephanie Smith
When viewed under a microscope, T cells - sentinels of the immune system whose job inside the body is to seek out foreign invaders - quiver as they surround and consume cancer cells. They were genetically modified in a lab by City of Hope researchers and trained to target specific receptors on patients’ brain tumors - part of an emerging approach to cancer care called immunotherapy.
January 4, 2017 | Stephanie Smith
Sketches of a brain surgery performed on B., one of several patients in a breakthrough clinical trial for brain cancer at City of Hope. Early results of the trial — describing promising results using CAR-T cells for a 50-year-old patient with an aggressive brain cancer called glioblastoma multiforme — were published recently in the New England Journal of Medicine.
October 17, 2016 | Denise Heady
Graduate student Dongrui Wang’s poster presentation at the 19th annual American Society of Gene & Cell Therapy was selected as the conference’s Outstanding Poster Presentation for his research initiatives in gene and cell therapy. Here Wang talks about what motivated him to pursue a career in science, what keeps him inspired and the innovative research he is working on at City of Hope.
September 13, 2016 | Jay Fernandez
One of the great benefits of medical breakthroughs is their potential for drawing great new curious minds to the field of medical science. One of those minds includes John P. Murad, a third-year graduate student working on a doctorate in biological sciences with an emphasis on cancer immunology and immune-based therapeutics.
July 11, 2016 | Denise Heady
Soon, brain cancer will be treated differently. Just ask scientist Christine Brown, Ph.D., associate director of the T Cell Immunotherapy Laboratory at City of Hope. Brown is on the forefront of a specific kind of immunotherapy: CAR-T cell therapy. Here, Brown tells us how this type of therapy works and what it could mean for future treatment.
January 19, 2016 | Sumanta Kumar Pal, M.D.
The recent state of the union address underscored a plan from the White House to lead a “moon shot” program – a massive effort to invest in cancer research with the ultimate goal of eradicating the disease. In order to reach this goal, while the amount of investment is critical, so too is the way in which funds are applied.
October 26, 2015 | City of Hope
Brain cancer is one of the toughest foes a doctor can face. It’s a tenacious form of cancer, inoperable in some cases and lethal in many. But at City of Hope, researchers are exploring new ways to conquer the most serious types of brain tumors in a clinical trial that deploys a patient’s own modified T cells to target cancer at the tumor site.
September 16, 2015 | Mandy Qualls
Acute lymphoblastic leukemia is the most common type of childhood cancer, accounting for about 30 percent of all pediatric cancers.
June 29, 2015 | City of Hope
Already pioneers in the use of immunotherapy, City of Hope researchers are now testing the bold approach to cancer treatment against one of medicine’s biggest challenges: brain cancer. This month, they will launch a clinical trial using patients’ own modified T cells to fight advanced brain tumors.
May 1, 2015 | City of Hope
Renowned physician researcher Larry Kwak takes the helm of City of Hope's new Toni Stephenson Lymphoma Center. Known for his ability to bring together, and lead, effective research teams, world-renowned translational research scientist and physician Larry W.