Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

breakthroughs - Behnam Badie and Christine Brown
City of Hope researchers find CAR-T cell therapy effective in treatment of glioblastoma

July 17, 2018 | Denise Heady

City of Hope researchers have found that using CAR-T therapy, a type of immunotherapy, can be effective in the treatment of glioblastoma — one of the most aggressive brain tumors known to medicine.

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CAR T Illuminated
CAR-T cells: ‘Soldiers of the Immune System’

July 10, 2017 | Stephanie Smith

When viewed under a microscope, T cells - sentinels of the immune system whose job inside the body is to seek out foreign invaders - quiver as they surround and consume cancer cells. They were genetically modified in a lab by City of Hope researchers and trained to target specific receptors on patients’ brain tumors - part of an emerging approach to cancer care called immunotherapy.

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breakthroughs- world cancer day
World Cancer Day: New treatments and cures start with collaborations

February 3, 2017 | Denise Heady

Defeating cancer cannot be done alone. It requires a team approach. Here are just a few examples of how City of Hope scientists and physicians are working together to create leading-edge approaches to end cancer.

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Breakthroughs - Dongrui Wang
Graduate student spotlight: Dongrui Wang and cancer immunotherapy

October 17, 2016 | Denise Heady

Graduate student Dongrui Wang’s poster presentation at the 19th annual American Society of Gene & Cell Therapy was selected as the conference’s Outstanding Poster Presentation for his research initiatives in gene and cell therapy. Here Wang talks about what motivated him to pursue a career in science, what keeps him inspired and the innovative research he is working on at City of Hope.

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Nick Troftgruben and his grandmother, Vonnie
19-year-old honors grandmother by raising money for brain cancer research

September 27, 2016 | Veronique de Turenne

When Nick Troftgruben lost his grandmother to brain cancer three years ago, he promised himself that he would do something significant to honor her memory. By organizing a four-month, 2,659 mile fundraising hike and generous donation to glioblastoma research at City of Hope, he fulfilled that pledge.

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Christine Brown Bio Portrait
Inside the lab: Training your immune system to fight cancer

July 11, 2016 | Denise Heady

Soon, brain cancer will be treated differently. Just ask scientist Christine Brown, Ph.D., associate director of the T Cell Immunotherapy Laboratory at City of Hope. Brown is on the forefront of a specific kind of immunotherapy: CAR-T cell therapy. Here, Brown tells us how this type of therapy works and what it could mean for future treatment.

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Breakthroughs - brain cancer research
New funding for CAR-T cell study gives brain cancer research a boost

October 26, 2015 | City of Hope

Brain cancer is one of the toughest foes a doctor can face. It’s a tenacious form of cancer, inoperable in some cases and lethal in many. But at City of Hope, researchers are exploring new ways to conquer the most serious types of brain tumors in a clinical trial that deploys a patient’s own modified T cells to target cancer at the tumor site.

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