Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

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Novel Treatment May Stop Graft-Versus-Host Disease

April 18, 2017 | Katie Neith

An international team of researchers led by City of Hope’s Defu Zeng believe they may have found a way to prevent graft-versus host disease following stem cell transplants without sacrificing the transplants’ ability to fight leukemia and lymphoma.

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Meditopes: Hitching cancer drugs to antibodies (w/VIDEO)

July 1, 2014 | Nicole White

Scientists have long searched for ways to bolster the immune system to fight diseases that seem to evade it, including cancer. City of Hope scientists discovered what they call a meditope, an opening in the center of an antibody and a peptide that fits neatly into it, creating the perfect "hitch" that allows medicines to be attached to the antibodies for delivery to tumor sites.

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Women's cancers: New treatments depend on innovation

March 16, 2014 | Elizabeth Stewart

In this series – this part explores the search for innovative new therapies – we explore crucial strides made against women's cancers by City of Hope researchers during the past year. The projects are many and varied, involving the basics of fighting cancer, analyses of who's at greatest risk, the search for surprising new therapies, the testing of new treatments and the follow-up with survivors and their partners.

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Meditope illustration
Cancer treatments without side effects? Meditopes could be answer

October 17, 2013 | Tami Dennis

“Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.” That’s the title of a study published online recently ahead of print in Proceedings of the National Academy of Sciences .

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