Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Kong-Mei
Collaboration leads to new pathway to increase drug sensitivity

October 19, 2016 | Katie Neith

Science doesn’t always start in the lab. Sometimes collaborations come together over cocktails in Costa Rica. This is how City of Hope cancer biologist Mei Kong Ph.D., and Caltech neuroscientist Viviana Gradinaru, Ph.D., started a project that could change the approach to killing cancerous tumors.

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Blood test
What makes City of Hope research different? Collaboration (w/VIDEO)

May 8, 2014 | Tami Dennis

Regardless of their institution, all cancer researchers want one thing – to find a cure for cancer. But City of Hope researchers have some advantages in this quest. The advantages start with a culture of collaboration.

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Paxil Bottle
Antidepressant Paxil boosts estrogen activity, new study finds

February 18, 2014 | Hiu Chung So

Humans are exposed to countless chemicals every day, so identifying the ones that can impact their health – specifically the ones that can increase cancer risk – is akin to looking for a sugar crystal in a salt shaker.

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Neural stem cells
Brain tumor research: 3 foundations back neural stem cell work

February 18, 2014 | Hiu Chung So

Despite gradual improvements over the years, brain tumors remain particularly tricky to treat. Treatment can affect normal brain tissue, which can cause physical and cognitive impairment. One particularly challenging obstacle is the blood-brain barrier, which prevents cancer drugs from passing into the brain and attacking the tumor.

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John Zaia, HIV expert
New CMV vaccine targets virus affecting third of transplant patients

February 2, 2014 | Nicole White

In most healthy adults, the immune system wages a winning battle against a virus that infects up to 80 percent of the population by age 40. Most never even know they have cytomegalovirus, or CMV. John Zaia, chair of the Department of Virology, checks on Jasson Duran, the first volunteer enrolled in a study of a new CMV vaccine developed and manufactured at City of Hope.

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Veliparib shows promise for BRCA-related breast cancer patients

January 9, 2014 | City of Hope

Of the estimated 230,000 new cases of breast cancer diagnosed annually in the U.S., approximately 12,000 patients carry harmful mutations on either the BRCA1 or BRCA2 genes. Researchers are investigating the effectiveness of various drugs against breast cancer, including the PARP inhibitor veliparib.

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200288760-001
Breast cancer spreads to brain by masquerading as neurons, study finds

January 9, 2014 | Nicole White

Often, several years can pass between the time a breast cancer patient successfully goes into remission and a related brain tumor develops. During that time, the breast cancer cells somehow hide, escaping detection as they grow and develop.

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Pancreas
Diabetes: Discovery could make growing islet cells easier

October 22, 2013 | Nicole White

Transplantation of insulin-producing islet cells is a potentially powerful tool for treating type 1 diabetes, but coming up with enough healthy donor cells for the procedure is difficult – at least for now.

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Chinese medicine compound could block liver cancer

October 18, 2013 | Darrin Joy

Liver cancer is tough to treat, and it’s on the rise. Now among the top 10 cancers diagnosed in the U.S. each year, it’s the third-deadliest cancer in the world. But a compound found in a traditional Chinese medicine may one day help halt the disease’s advance.

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