Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Rahul Jandial in the lab
Inside the Lab: Preventing breast cancer from invading the brain

July 24, 2017 | Denise Heady

A study led by City of Hope neurosurgeon and scientist Rahul Jandial, M.D., Ph.D., offers novel insights on how cancer cells in HER2-positive breast cancer develop the ability to break through the blood-brain barrier and, ultimately, how they can be stopped.

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breakthroughs - Behnam Badie and Christine Brown
City of Hope researchers find CAR-T cell therapy effective in treatment of glioblastoma

July 17, 2017 | Denise Heady

City of Hope researchers have found that using CAR-T therapy, a type of immunotherapy, can be effective in the treatment of glioblastoma — one of the most aggressive brain tumors known to medicine.

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CAR T Illuminated
CAR-T cells: ‘Soldiers of the Immune System’

July 10, 2017 | Stephanie Smith

T cells were genetically modified in a lab by City of Hope researchers and trained to target specific receptors on patients’ brain tumors - part of an emerging approach to cancer care called immunotherapy.

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rahul jandial headshot 256 x 256
Wolf in sheep's clothing: breast cancer cloaks itself in brain proteins to invade the brain

March 14, 2017 | Denise Heady

More women than ever are surviving breast cancer only to die of secondary brain tumors years after they’ve been declared cancer-free. This is particularly true for patients with the breast cancer subtype HER2-positive. Now City of Hope researchers have discovered how this happens.

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breakthroughs - Dr. Jandial in Peru
A doctor’s quest to better treat children with brain tumors in underserved countries

January 12, 2017 | Denise Heady

City of Hope's Rahul Jandial, M.D., Ph.D., is making a lasting and global impact by performing and teaching children's brain surgery in developing countries.

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Inside CAR T 256 x 256
Inside CAR-T Cell Glioblastoma Surgery

January 4, 2017 | Stephanie Smith

Sketches of a brain surgery performed on B., one of several patients in a breakthrough clinical trial for brain cancer at City of Hope. Early results of the trial — describing promising results using CAR-T cells for a 50-year-old patient with an aggressive brain cancer called glioblastoma multiforme — were published recently in the New England Journal of Medicine.

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Breakthroughs - brain cancer research
Using CAR-T cell immunotherapy to target glioblastomas

December 14, 2016 | Denise Heady

One of but a few centers in the United States offering human studies in CAR–T cell therapy, City of Hope is the only center investigating CAR-T cells in injection form administered directly to brain tumors.

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