Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Wolf in sheep's clothing: breast cancer cloaks itself in brain proteins to invade the brain

March 14, 2017 | Denise Heady

More women than ever are surviving breast cancer only to die of secondary brain tumors years after they’ve been declared cancer-free. This is particularly true for patients with the breast cancer subtype HER2-positive. Now City of Hope researchers have discovered how this happens.

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A doctor’s quest to better treat children with brain tumors in underserved countries

January 12, 2017 | Denise Heady

City of Hope's Rahul Jandial, M.D., Ph.D., is making a lasting and global impact by performing and teaching children's brain surgery in developing countries.

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Inside CAR-T Cell Brain Surgery

January 4, 2017 | Stephanie Smith

Sketches of a brain surgery performed on B., one of several patients in a breakthrough clinical trial for brain cancer at City of Hope. Early results of the trial — describing promising results using CAR-T cells for a 50-year-old patient with an aggressive brain cancer called glioblastoma multiforme — were published recently in the New England Journal of Medicine.

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CAR-T cells: ‘Soldiers of the Immune System’

December 30, 2016 | Stephanie Smith

When viewed under a microscope, T cells - sentinels of the immune system whose job inside the body is to seek out foreign invaders - quiver as they surround and consume cancer cells. They were genetically modified in a lab by City of Hope researchers and trained to target specific receptors on patients’ brain tumors - part of an emerging approach to cancer care called immunotherapy.

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City of Hope researchers find CAR-T cell therapy effective in treatment of glioblastoma

December 29, 2016 | Denise Heady

City of Hope researchers have found that using CAR-T therapy, a type of immunotherapy, can be effective in the treatment of glioblastoma — one of the most aggressive brain tumors known to medicine.

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Using CAR-T cell immunotherapy to target glioblastomas

December 14, 2016 | Denise Heady

One of but a few centers in the United States offering human studies in CAR–T cell therapy, City of Hope is the only center investigating CAR-T cells in injection form administered directly to brain tumors.

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19-year-old honors grandmother by raising money for brain cancer research

September 27, 2016 | Veronique de Turenne

When Nick Troftgruben lost his grandmother to brain cancer three years ago, he promised himself that he would do something significant to honor her memory. By organizing a four-month, 2,659 mile fundraising hike and generous donation to glioblastoma research at City of Hope, he fulfilled that pledge.

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Mother honors son with comedy fundraiser for brain cancer research

May 12, 2016 | Denise Heady

Diane Peacock uses May, Brain Tumor Awareness Month, as a time to recognize, remember and spread awareness about brain cancer - the deadly disease that took her son’s life when he was just four days shy of his 19th birthday.

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