Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

breakthroughs - Behnam Badie and Christine Brown
City of Hope researchers find CAR-T cell therapy effective in treatment of glioblastoma

July 17, 2018 | Denise Heady

City of Hope researchers have found that using CAR-T therapy, a type of immunotherapy, can be effective in the treatment of glioblastoma — one of the most aggressive brain tumors known to medicine.

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Breakthroughs - brain tumors and cancer - what you need to know - 256x256
Brain tumors and cancer: what you need to know

July 18, 2017 | Denise Heady

Say the words “brain tumor” and most people will likely think of cancer. But the truth is, having a brain tumor doesn’t always lead to a cancer diagnosis.

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Behnam Badie in Surgery
MEET OUR DOCTORS: Behnam Badie on why ‘being a neurosurgeon is not enough’

July 17, 2017 | Denise Heady

Driven in part by the plight of his patients and his father, chief of neurosurgery Behnam Badie, M.D., spends nearly as much time in the laboratory as he does in the operating room. He wants to help not just today's patients, but tomorrow's. 

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CAR T Illuminated
CAR-T cells: ‘Soldiers of the Immune System’

July 10, 2017 | Stephanie Smith

When viewed under a microscope, T cells - sentinels of the immune system whose job inside the body is to seek out foreign invaders - quiver as they surround and consume cancer cells. They were genetically modified in a lab by City of Hope researchers and trained to target specific receptors on patients’ brain tumors - part of an emerging approach to cancer care called immunotherapy.

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Rahul Jandial, M.D.
Cancer insights: Cancer patients are superhuman

June 5, 2017 | Rahul Jandial, M.D., Ph.D.

In the past seven years at City of Hope, I’ve had the privilege of providing care for many patients with cancer. Quite simply, they are the real superhumans. Please allow me to offer four examples for your consideration, from my personal insight.

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breakthroughs - behnam badie
Behnam Badie awarded $2.1 million R01 grant to help patients with aggressive brain tumors

April 24, 2017 | Denise Heady

What started as an unplanned lunch date has turned into a potential breakthrough in the treatment of gliomas – a fast-growing, and often deadly type of brain tumor.

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breakthroughs - brain tumor
New Compound Discovered in the Battle Against Brain Cancer

January 30, 2017 | City of Hope

A study led by scientists at the Translational Genomics Research Institute (TGen), a City of Hope affiliate, has identified "a potent inhibitory compound" in the elusive hunt for an improved treatment against glioblastoma, the most common and deadly type of adult brain cancer.

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breakthroughs - Dr. Jandial in Peru
A doctor’s quest to better treat children with brain tumors in underserved countries

January 12, 2017 | Denise Heady

City of Hope's Rahul Jandial, M.D., Ph.D., is making a lasting and global impact by performing and teaching children's brain surgery in developing countries.

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Inside CAR T 256 x 256
Inside CAR-T Cell Brain Surgery

January 4, 2017 | Stephanie Smith

Sketches of a brain surgery performed on B., one of several patients in a breakthrough clinical trial for brain cancer at City of Hope. Early results of the trial — describing promising results using CAR-T cells for a 50-year-old patient with an aggressive brain cancer called glioblastoma multiforme — were published recently in the New England Journal of Medicine.

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Christine Brown Bio Portrait
Inside the lab: Training your immune system to fight cancer

July 11, 2016 | Denise Heady

Soon, brain cancer will be treated differently. Just ask scientist Christine Brown, Ph.D., associate director of the T Cell Immunotherapy Laboratory at City of Hope. Brown is on the forefront of a specific kind of immunotherapy: CAR-T cell therapy. Here, Brown tells us how this type of therapy works and what it could mean for future treatment.

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