Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

City of Hope Neurosurgeon, Behnam Badie, M.D.
Patient and Pioneer Richard Grady: His Contributions to Advance Our Research in Treating Brain Tumors Is His Lasting Legacy

August 2, 2017 | Behnam Badie, M.D., F.A.C.S.

My life is devoted to finding a cure for brain cancer. Patients come to us seeking miracles, but often what they give us back is invaluable knowledge. Throughout history, patients have helped revolutionize science and medicine. Many patients, like my dad, do not survive. But they leave behind a legacy of knowledge and hope for other patients today, and for future generations. Richard Grady was that kind of patient.

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Breakthroughs - brain tumors and cancer - what you need to know - 256x256
Brain tumors and cancer: what you need to know

July 18, 2017 | Denise Heady

Say the words “brain tumor” and most people will likely think of cancer. But the truth is, having a brain tumor doesn’t always lead to a cancer diagnosis.

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Behnam Badie in Surgery
MEET OUR DOCTORS: Behnam Badie on why ‘being a neurosurgeon is not enough’

July 17, 2017 | Denise Heady

Driven in part by the plight of his patients and his father, chief of neurosurgery Behnam Badie, M.D., spends nearly as much time in the laboratory as he does in the operating room. He wants to help not just today's patients, but tomorrow's. 

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breakthroughs - Behnam Badie and Christine Brown
City of Hope researchers find CAR-T cell therapy effective in treatment of glioblastoma

July 17, 2017 | Denise Heady

City of Hope researchers have found that using CAR-T therapy, a type of immunotherapy, can be effective in the treatment of glioblastoma — one of the most aggressive brain tumors known to medicine.

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CAR T Illuminated
CAR-T cells: ‘Soldiers of the Immune System’

July 10, 2017 | Stephanie Smith

When viewed under a microscope, T cells - sentinels of the immune system whose job inside the body is to seek out foreign invaders - quiver as they surround and consume cancer cells. They were genetically modified in a lab by City of Hope researchers and trained to target specific receptors on patients’ brain tumors - part of an emerging approach to cancer care called immunotherapy.

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Leo Wang
Meet our doctors: How Leo Wang is revolutionizing the way that pediatric and blood cancers are treated

March 17, 2017 | Denise Heady

Dual-trained pediatric oncologist and scientist Leo Wang, M.D., Ph.D., is working in the lab to understand how blood cells develop and grow, and plans to use that information to help patients with cancer live longer and experience fewer side effects of treatment.

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breakthroughs - t cells
INSIDE THE LAB: Tracking T cells in the brain

January 27, 2017 | Denise Heady

City of Hope researchers have seen initial success treating brain cancer patients with CAR-T cell therapy, yet questions still linger about what exactly happens to these cells once they disperse through the brain. A new imaging technique may be the answer.

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Inside CAR T 256 x 256
Inside CAR-T Cell Brain Surgery

January 4, 2017 | Stephanie Smith

Sketches of a brain surgery performed on B., one of several patients in a breakthrough clinical trial for brain cancer at City of Hope. Early results of the trial — describing promising results using CAR-T cells for a 50-year-old patient with an aggressive brain cancer called glioblastoma multiforme — were published recently in the New England Journal of Medicine.

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Breakthroughs - brain cancer research
Using CAR-T cell immunotherapy to target glioblastomas

December 14, 2016 | Denise Heady

One of but a few centers in the United States offering human studies in CAR–T cell therapy, City of Hope is the only center investigating CAR-T cells in injection form administered directly to brain tumors.

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