Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Rahul Jandial in the lab
Inside the Lab: Preventing breast cancer from invading the brain

July 24, 2017 | Denise Heady

A study led by City of Hope neurosurgeon and scientist Rahul Jandial, M.D., Ph.D., offers novel insights on how cancer cells in HER2-positive breast cancer develop the ability to break through the blood-brain barrier and, ultimately, how they can be stopped.

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CAR T Illuminated
CAR-T cells: ‘Soldiers of the Immune System’

July 10, 2017 | Stephanie Smith

When viewed under a microscope, T cells - sentinels of the immune system whose job inside the body is to seek out foreign invaders - quiver as they surround and consume cancer cells. They were genetically modified in a lab by City of Hope researchers and trained to target specific receptors on patients’ brain tumors - part of an emerging approach to cancer care called immunotherapy.

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City of Hope Researcher Receives Grant to Improve Cognitive Outcomes in Young Cancer Patients

July 7, 2017 | Samantha Bonar

Sunita Patel, Ph.D., a neuropsychologist in the Population Sciences and Supportive Care Medicine departments at City of Hope, has received a $1.22 million grant from the American Cancer Society to test a new approach toward preventing long-term chemotherapy-related cognitive side effects in childhood cancer survivors from bilingual and Spanish-speaking families.

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Immunotherapy Drug Shown Safe and Effective in Treating Hodgkin Lymphoma

June 29, 2017 | Katie Neith

Clinical trial results in positive outcomes for patients with relapsed or treatment-resistant disease. Hodgkin lymphoma is typically considered to be one of the most curable forms of cancer, but some with the disease relapse or find that their cancer is resistant to treatment. For patients like this, a fully human monoclonal antibody called avelumab has shown promising results in a phase 1 clinical trial for safety and efficacy.

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Dan Rojas
HIV Stem Cell Trial Patient Strives, Cycles for a Cure

June 13, 2017 | Samantha Bonar

Dan Rojas, 31, who has been living with HIV since 2011, is one of a handful of brave patients participating in a groundbreaking study at City of Hope that seeks a cure for AIDS.

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bladder cancer
A ‘Multifront’ Approach: Breakthroughs in Bladder Cancer

May 16, 2017 | Abe Rosenberg

Bladder cancer is a stubborn disease. Malignant cells in the bladder frequently grow back or pop up elsewhere, even if they're removed in their earliest stages. But the City of Hope surgeons and scientists working to eradicate bladder cancer are equally stubborn.

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breakthroughs - Virgina Sun
New Study Aims to Improve Quality of Life for Ostomy Patients

April 20, 2017 | Samantha Bonar

A new study is aimed at helping recent cancer survivors who have ostomies. The three-year randomized controlled trial is an ostomy self-management training program that hopes to coach cancer survivors to care for their ostomies via teleconferencing.

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Myeloma Series CAR T Wang homepage image
CAR-T Cell Trial for Multiple Myeloma to Launch in 2017

March 22, 2017 | Travis Marshall

CAR-T cell therapy research at City of Hope is an innovative and promising approach that recruits the body’s own immune system in the fight against some of the hardest-to-treat cancers, including multiple myeloma.

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Hurria-Arti
As new City of Hope vice provost, Arti Hurria wants to give back

March 7, 2017 | Letisia Marquez

As new vice provost for clinical faculty for City of Hope, Arti Hurria, M.D., will have primary oversight of academic and faculty affairs for physician faculty in the clinical professor series. She supports City of Hope’s mission to increase the diversity of clinical faculty, and is responsible for designing, implementing and assessing various programs to address faculty diversity, recruitment, retention and advancement.

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Inside CAR T 256 x 256
Inside CAR-T Cell Brain Surgery

January 4, 2017 | Stephanie Smith

Sketches of a brain surgery performed on B., one of several patients in a breakthrough clinical trial for brain cancer at City of Hope. Early results of the trial — describing promising results using CAR-T cells for a 50-year-old patient with an aggressive brain cancer called glioblastoma multiforme — were published recently in the New England Journal of Medicine.

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