Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Rahul Jandial in the lab
Inside the Lab: Preventing breast cancer from invading the brain

July 24, 2017 | Denise Heady

A study led by City of Hope neurosurgeon and scientist Rahul Jandial, M.D., Ph.D., offers novel insights on how cancer cells in HER2-positive breast cancer develop the ability to break through the blood-brain barrier and, ultimately, how they can be stopped.

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CAR T Illuminated
CAR-T cells: ‘Soldiers of the Immune System’

July 10, 2017 | Stephanie Smith

When viewed under a microscope, T cells - sentinels of the immune system whose job inside the body is to seek out foreign invaders - quiver as they surround and consume cancer cells. They were genetically modified in a lab by City of Hope researchers and trained to target specific receptors on patients’ brain tumors - part of an emerging approach to cancer care called immunotherapy.

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patel sunita 256x256
City of Hope Researcher Receives Grant to Improve Cognitive Outcomes in Young Cancer Patients

July 7, 2017 | Samantha Bonar

Sunita Patel, Ph.D., a neuropsychologist in the Population Sciences and Supportive Care Medicine departments at City of Hope, has received a $1.22 million grant from the American Cancer Society to test a new approach toward preventing long-term chemotherapy-related cognitive side effects in childhood cancer survivors from bilingual and Spanish-speaking families.

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Inside CAR T 256 x 256
Inside CAR-T Cell Brain Surgery

January 4, 2017 | Stephanie Smith

Sketches of a brain surgery performed on B., one of several patients in a breakthrough clinical trial for brain cancer at City of Hope. Early results of the trial — describing promising results using CAR-T cells for a 50-year-old patient with an aggressive brain cancer called glioblastoma multiforme — were published recently in the New England Journal of Medicine.

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breakthroughs - ASH
ASH 2016: Groundbreaking new trials show promise for lymphoma and multiple myeloma patients

December 7, 2016 | City of Hope

Numerous clinical trials, which lay the groundwork for novel approaches to lymphoma and multiple myeloma therapies, could ultimately lead to new treatments that improve survival and quality of life for patients with those and other diseases. Additional studies give new insight into best practices for the treatment of various blood cancers.

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Rosen-Steven
City of Hope's Steven T. Rosen, M.D., on the Impact of the TGen Alliance

December 1, 2016 | City of Hope

In this Q and A, Steven T. Rosen, M.D., provost and chief scientific officer for City of Hope, answers questions about the importance of precision of medicine in the fight against cancer and how the City of Hope and TGen alliance will advance research and treatment using this approach.

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breakthroughs - stock lab image
Genetic Testing and Research: A Key Focus for Tackling the Most Aggressive Types of Thyroid Cancer

November 15, 2016 | Travis Marshall

For most people diagnosed with thyroid cancer, treatment is a relatively straightforward combination of surgery and radioactive iodine treatment. But that is not always the case. Behrouz Salehian, M.D., discusses the different ways to treat this disease.

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GMP facility at City of Hope
Manufacuring novel cell therapies for clinical trials targeting heart, lung and blood diseases

September 22, 2016 | Letisia Marquez

The novel cell therapies will be used in preclinical trials funded by the National Heart, Lung, and Blood Institute.

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Behind the scenes of a clinical trail
Behind the scenes of a clinical trial

July 21, 2016 | City of Hope

At City of Hope, at least 400 clinical trials are going on at any given time. To help illuminate the clinical trial process for patients, here are five facts you may not have known.

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