Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Breakthroughs - CRIM grant
$7.38 million grant will benefit new treatments for fatal childhood disease

March 17, 2016 | City of Hope

City of Hope's efforts to fight and cure Canavan disease -- a rare yet fatal disorder that strikes within the first 3 to 6 months of an infant's life -- just got a $7.38 million boost from the California Institute for Regenerative Medicine (CIRM).

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Study: Researchers develop new method of targeting cancer stem cells

March 3, 2016 | Letisia Marquez

Research into a promising therapeutic target for glioblastoma was recently published in the journal Nature Communications. City of Hope scientists are working to uncover how cancer stem cells grow, and what can be done to stop them from multiplying.

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Leukemia cells
Scientists explore new approach to acute myeloid leukemia

December 10, 2015 | Chase Doyle

Sometimes, just a few remaining cancer cells can mean the difference between remission and relapse. For patients with aggressive bone marrow disease such as acute myeloid leukemia (AML), this distinction can be deadly.

City of Hope researchers are determined to eliminate those remaining cancer cells and, in doing so, improve patient survival. First, however, they must understand how resistance works.

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stem cell
CIRM grant will ease bottleneck in stem cell research

January 30, 2015 | Nicole White

The lack of a practical way to produce and store enough stem cells for larger-scale therapies and clinical trials is creating a bottleneck in stem cell research. A new grant to City of Hope from the California Institute for Regenerative Medicine (CIRM) will help solve that problem.

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Happy Birthday, CIRM! 10 years, 10 new stem cell therapies

November 28, 2014 | Nicole White

City of Hope joined other leaders in stem cell research to celebrate 10 years since voters approved funding for the California Institute for Regenerative Medicine, or CIRM. On its 10th birthday, the California Institute for Regenerative Medicine celebrated 10 stem cell therapies that have been approved for clinical trials, including an HIV/AIDS trial at City of Hope.

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Leukemia: Combo treatment can kill disease stem cells, study says

August 28, 2013 | Nicole White

Just as stem cells generate bone marrow and blood cells, while maintaining their constant production, leukemia has its own stem cells. These cancer-generating cells are tough to kill – and tend to be resistant to treatment.

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brain neurons
A spoonful of cholesterol helps the neurons to grow

December 27, 2012 | Shawn Le

One popular misconception about the brain is that it stops growing in adulthood. Neurons make up the brain and central nervous system. Disease can destroy neurons much faster than they can be replaced.

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Krist T. Azizian
Blood stem cells - evolving compensation

March 5, 2012 | Krist Azizian

Disrupting a critical molecular pathway for blood development reveals biology’s robustness. Some faint at the sight of it. Others relish seeing it splattered gratuitously in vampire movies. Blood, with all its symbolism, has intrigued mankind for millennia.

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CIRM Trainees
Hope for the future of science and medicine

February 29, 2012 | City of Hope

Highlights on CIRM Bridges to Stem Cell Research Trainees: Michael Silva, Megan Gilchrist and Kenna Schnarr Michael Silva Master of Science Candidate California State University, Channel Islands For me, hope has become a way of life.

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