The purposes of the laboratory rotations are to help students find the research area and lab in which they want to conduct their thesis research, learn experimental techniques, and expose students to a broad range of intellectual and technical approaches to address current research challenges. Each laboratory rotation lasts for approximately 9 weeks. Students are expected to spend approximately 25 hours per week in the laboratory, and each graduate student must complete a written report, and short speaking presentation, at the end of each rotation.
This 2.5-week course aims to help students navigate the ethical decision making through a combination of lectures, discussions and writing assignments. The key areas to be addressed are ethics and the scientist, ethical use of animals in research, ethical use of humans in research, conflict of interest, mentor/mentee responsibilities, responsible authorship and publication and peer review, record keeping, ethical issues surrounding cloning and transgenics and stem cell research. Issues surrounding best laboratory practices, as well as rigor and reproducibility will also be discussed
This course will provide a graduate-level foundation of key concepts in molecular and cellular biochemistry. Furthermore, this course aims to stimulate the acquisition and utilization of essential concepts and terms; to encourage the transition from passive learning from textbooks to active learning from the primary literature; to provide the students the opportunity to begin interpreting experimental results within the context of a body of work; and develop the skills of articulating the concepts of hypothesis, significance, and innovation. The topics presented will include key concepts in gene expression, protein structure and post-translational modifications, and their relevance to Cancer Biology. A key learning goal is application of the fundamental concepts that will be guiding their own experiments.
This course is an extension of the learning goals of BIOSCI 521, with additional topics that are also central to molecular and cellular biochemistry. The topics presented will include key concepts in metabolism, cell signaling, pancreas function, Immunology, and their relevance to Metabolic Disorders
The purpose of this course is to combine biostatistics and computational molecular biology to make one integrated course that includes didactic lectures and hands-on silico laboratory sessions. This course will cover the statistical methods relevant to biological data analysis, and introduce the range of computational methods and their applications from sequence-based methods to atomistic to tissue level modeling.
The goal of this course is to foster the development of essential skill set for the professional scientist, and this includes reading the scientific literature, writing, discussion, critique, and debate. This course will also permit students to leverage their prior training toward deepening their fund of scientific knowledge and developing greater independence in evaluating the merits of different experimental approaches and bodies of work. An additional goal of the course is to expose students to major areas of Biomedical Research at the Beckman Research Institute of the City of Hope.
The goal of this course is to apply the skills attained in the prior core courses, and BIOSCI 550 in particular, and demonstrate proficiency in developing a hypothesis and associated experiments, and articulating the significance and innovation of the hypothesis. Students will meet these learning goals by identifying a recent primary literature paper that is of interest to the student, critiquing that paper, identifying an unanswered question from the paper, and developing a hypothesis and associated set of experiments to address such a question. Students will prepare a written document with these elements, and defend them in a speaking presentation, each using a predetermined format.
The ability to write high-quality, professional manuscripts and grant proposals is a necessary skill for biomedical researchers. This course addresses advanced topics in scientific writing, with a focus on developing, organizing, and writing larger documents for logical consistency and readability. The course incorporates lectures, discussions, and “hands-on” writing assignments to help students understand the importance of strong writing skills and preparation and organization in scientific writing. Students will learn how to develop major sections of common scientific documents (e.g., manuscripts, grant proposals, and fellowships). The course provides students with the experience of writing longer scientific documents and having their work critiqued.
Students are required to complete one Advance Course prior to graduation. Available topics for the Advance Courses include Comparative Medicine - Mouse in Biomedical Research, Cancer Biology, Immunology, Virology, Stem Cell Biology, RNA, DNA Repair and Epigenetics and Cancer, Cancer Metabolism, Mathematic Modeling and Methods for Biomedical Science, and Medicinal Chemistry – Drug Delivery.
Every student after the first year is required to participate in a journal club, where members take turns presenting a current research article to the group. Participants must attend all seminars and make at least one presentation. Available topics for the journal clubs are Comparative Medicine, Current Science, DNA Repair and Recombination, Epigenetics and Chromatin Structure, Immunology, Protein Post-Translational Modification, RNA + Epigenetics and Chromatin Structure, RNA, Signal and Regulation with Translational Focus, Stem Cell Biology, Structural and Chemical Biology, and Tumor Immunology.
The Leading-Edge Lectures (LEL) is sponsored by the students. Each year the students select outstanding biomedical scientists to present a research seminar. Before each talk, the students and the faculty administrator will meet for a presentation and discussion session. Here, the student sponsor will summarize one or two of the most relevant articles by the invited scientist and lead a discussion of the techniques and data with the other students. Students will then attend the seminar and lead the question and answer session that follows.
Credit Hour Policy
Trimester: Irell & Manella Graduate School of Biological Sciences at City of Hope is on a trimester system. Each trimester (Fall, Spring, Summer) is approximately 17 weeks. Once students advance to candidacy they are expected to perform research for 17 weeks per trimester unless on leave.
- Transfer credit policy, criteria, articulation agreements as Required in accordance with U.S. Department of Education regulation 668.43(a)(11): transfer policy needs to be publically disclosed; must include criteria regarding transfer of credit and a list of institutions with which it has established an articulation agreement.