Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

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Pediatric Clinical Trials

April 25, 2017 | City of Hope

Our team of clinical specialists and researchers are pioneering innovative treatments for pediatric cancer and childhood diseases, including advances in gene therapy, immunotherapy and targeted therapy.

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Categories : Clinical Trials

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Multiple Myeloma CAR-T Cell Trial to launch in 2017

April 3, 2017 | Travis Marshall

An upcoming phase 1 clinical trial at City of Hope will look at the effects of CAR-T cells programmed to target a protein called CS-1, which is found on myeloma cells.

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Alpha Clinic Network: Experts Discuss Advancements in Stem Cell Therapies

March 28, 2017 | Michael Easterling

Patients who have benefited from stem cell therapies funded by CIRM were the focus of the second symposium of the Alpha Stem Cell Clinics Network.

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Study: Stem Cell Transplants May Lead to Cure for Some T1D Patients

March 7, 2017 | Letisia Marquez

Clinical trial shows promising results from risky procedure, identifies path for personalized therapies. The results were published recently in the journal, Frontiers in Immunology.

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Researchers achieve remission using CAR-T Cell therapy for aggressive brain tumors

February 15, 2017 | Denise Heady

City of Hope case study published in the New England Journal of Medicine reported treatment with reengineered CAR-T cells dramatically improved quality of life for patient with recurrent glioblastoma.

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Hodgkin Lymphoma Trial Results Promising

January 9, 2017 | Abe Rosenberg

Everything changed when a Hodgkin lymphoma patient joined a Phase II clinical trial examining the effectiveness of brentuximab vedotin (BV) after a failed transplant. The BV worked immediately, achieving a complete remission which, year after year, proved to be durable beyond anyone's expectations.

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Cutaneous Lymphoma Clinical Trials

December 16, 2016 | City of Hope

While treatment therapies exist for CTCL (MF/SS) and other cutaneous lymphomas, the most prevalent therapies have not yet offered consistent and sustained response or cure. Our multidisciplinary team continues to provide leadership in research and in developing therapies to advance a cure.

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Categories : Clinical Trials

Breakthroughs - brain cancer research
Using CAR-T cell immunotherapy to target glioblastomas

December 14, 2016 | Denise Heady

One of but a few centers in the United States offering human studies in CAR–T cell therapy, City of Hope is the only center investigating CAR-T cells in injection form administered directly to brain tumors.

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Study finds Triplex vaccine safe for use in healthy populations

December 14, 2016 | City of Hope

Data published in Blood supports ongoing phase 2 trial of Triplex in allogeneic hematopoietic stem cell transplant recipients.

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ASH 2016: Innovative new trials show promise for lymphoma and multiple myeloma patients

December 7, 2016 | City of Hope

Numerous clinical trials, which lay the groundwork for novel approaches to lymphoma and multiple myeloma therapies, could ultimately lead to new treatments that improve survival and quality of life for patients with those and other diseases. Additional studies give new insight into best practices for the treatment of various blood cancers.

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