An NCI-designated Comprehensive Cancer Center

Breakthroughs Blog Old

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Breast Cancer Cell 500X500

Moving toward the next
level in breast cancer CAR T cell therapy

October 31, 2019 | City of Hope

City of Hope is accelerating the development of treatment options for patients with breast cancer who have challenging tumors and poor prognosis with a phase 1 clinical trial that is enrolling patients with refractory HER2-positive breast cancer with brain metastases to test the safety and effectiveness of CAR T cell therapy.

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HPV cells

Innovative approach using KITE-439 in targeting HPV-related malignancies

August 20, 2019 | City of Hope

HPV16-induced cancers, a strain that causes about 70% of all cervical cancers worldwide, are ideal candidates for targeted T cell therapy due to their nonself antigens.

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breakthroughs - liver cancer

ET140202 Artemis T Cell therapy for the treatment of liver cancer

August 20, 2019 | City of Hope

City of Hope is the first institution in the United States to open an immunotherapy clinical trial for liver cancer that eventually could transform treatment of the usually fatal disease into an outpatient procedure.

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Breakthroughs - prostate cancer clinical trial

PSCA as a novel CAR T target for resistant prostate cancer

August 20, 2019 | City of Hope

In this phase 1 trial, the safety and tolerability of autologous anti-PSCA-CAR-4-1BB/TCRzeta-CD19t-expressing T lymphocytes are studied in adult patients with PSCA+ metastatic castration-resistant prostate cancer.

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breakthroughs - t cells

ASCO research highlights: First KRAS inhibitor and CAR T cell therapy for CLL

June 28, 2019 | City of Hope

At ASCO, City of Hope presented on a number of topics, but some of the most noteworthy involved the first KRAS inhibitor to show anti-tumor activity and the use of CAR T cell therapy in chronic lymphocytic leukemia.

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AML | City of Hope

City of Hope investigates a novel therapeutic approach in AML

April 26, 2019 | City of Hope

City of Hope opens recruitment for a phase I/II dose-finding study of novel agent 8-chloro-adenosine in patients with relapsed/refractory acute myeloid leukemia.

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Blood Cancer | City of Hope

City of Hope launches first CAR T cell trial targeting CS1 protein in multiple myeloma

April 26, 2019 | City of Hope

City of Hope is now enrolling relapsed/refractory multiple myeloma patients for a first-of-its kind chimeric antigen receptor T cell therapy phase I trial.

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Image of cytomegaloviruses

City of hope innovating how to decrease cmv infections in transplants via novel vaccine approach

February 26, 2019 | City of Hope

Cytomegalovirus (CMV) can cause severe and life-threatening disease in patients undergoing a stem cell or solid organ transplant. City of Hope researchers have been developing a novel vaccine against CMV to decrease the risk of infections in this procedure.

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Categories : Clinical Trials

Lung Cancer

The Changing Landscape of Lung Cancer Therapy

November 27, 2018 | City of Hope

City of Hope clinical trials reflect the rapidly changing landscape of lung cancer therapy. We continue to pioneer treatment in lung cancer with trials that incorporate biomarker testing and immunotherapy.

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CAR T

First-of-its-kind CAR T clinical trial enrolls HER2+ breast cancer patients with brain metastases

October 30, 2018 | City of Hope

City of Hope is now enrolling patients in a phase 1 trial evaluating the safety and efficacy of CAR T cell therapy in patients with HER2+ breast cancer that has metastasized to the brain.

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