Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Yanhong Shi and Qi
City of Hope Researchers Take Aim at Brain Cancer

April 4, 2017 | Katie Neith

Yanhong Shi, Ph.D., professor and director of the Division of Stem Cell Biology Research at Beckman Research Institute of City of Hope, believes she and colleagues have found a way to suppress the growth and self-renewal in a certain type of cancer stem cell.

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jeremy jones lab
Promising Target for Prostate Cancer Identified

March 29, 2017 | Katie Neith

Prostate cancer is the third leading cancer killer among men. Now, a team from City of Hope believes they have found a key mechanism for potentially keeping the disease at bay, both before and after diagnosis.

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breakthroughs - cancer cells
Researchers discover sugar uptake and energy supply may play a key role in the relapse of ALL

March 14, 2017 | Katie Neith

A paper published in the Feb. 13 issue of the journal Nature points to increased glucose as the driver of the energy needed for specific cells to transform into malignant cancer cells.

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breakthroughs - t cells
Tracking T cells in the Brain with Reporter Genes

March 6, 2017 | Denise Heady

Researchers have designed a method to engineer Car-T cells with something called a "reporter" gene, so they can be tracked and monitored by scientists once they are injected into a patient’s brain.

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stem cells
For Some Type 1 Diabetes Patients, Stem Cell Transplants Lead to Cure

March 1, 2017 | Katie Neith

A clinical trial monitored by Bart Roep, Ph.D., showed promising results for a possible cure of type 1 diabetes (T1D). The study identified new paths for personalized therapies of T1D.

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Early Next-generation Sequencing Tests May Offer Some Benefits

February 28, 2017 | Jyoti Madhusoodanan

Coupled with new drugs that target tumor-specific genomic changes, next-generation sequencing (NGS) tests have the potential to transform modern cancer care.

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Alex F. Herrera takes on double-hit and double-expressor lymphomas

February 1, 2017 | Letisia Marquez

Alex F. Herrera, M.D. and a team of doctors from City of Hope and the Dana-Farber Cancer Institute examined how patients whose double-hit and/or double-expressor lymphoma had recurred, or was resistant to initial treatment, fared after undergoing high-dose chemo and stem cell transplantation.

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Phase II Trial Results Point to Promising Treatments for Hodgkin Lymphoma

January 9, 2017 | Abe Rosenberg

Everything changed when Hodgkin lymphoma patient Lowell Winer joined a Phase II clinical trial examining the effectiveness of brentuximab vedotin (BV) after a failed transplant. The BV worked immediately, achieving a complete remission which, year after year, proved to be durable beyond anyone's expectations.

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breakthroughs - Dr. Yuan and Susan
Experimental Treatment Using Breast Cancer Vaccine Gives Patient New Hope

December 8, 2016 | Samantha Bonar

City of Hope patient Susan Young - diagnosed with late-stage triple negative breast cancer - has had a remarkable response to a revolutionary new treatment, a combination of the p53 cancer vaccine and a drug that blocks a specific cancer-aiding protein.

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breakthroughs - ASH
ASH 2016: Groundbreaking studies show promise for lymphoma and multiple myeloma patients

December 7, 2016 | City of Hope

Numerous clinical trials, which lay the groundwork for novel approaches to lymphoma and multiple myeloma therapies, could ultimately lead to new treatments that improve survival and quality of life for patients with those and other diseases. Additional studies give new insight into best practices for the treatment of various blood cancers.

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