Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

CAR-T
Get Access Now: Car-t Cell Therapy for Aggressive Non-Hodgkin Lymphoma

November 17, 2017 | City of Hope

City of Hope is now offering the first-ever FDA-approved CAR-T cell therapy for adult patients with certain types of large B-cell lymphoma who have not responded to or who have relapsed after at least two other kinds of treatment.

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breakthroughs - Behnam Badie and Christine Brown
Researchers achieve remission using CAR-T Cell therapy for aggressive brain tumors

February 15, 2017 | Denise Heady

City of Hope case study published in the New England Journal of Medicine reported treatment with reengineered CAR-T cells dramatically improved quality of life for patient with recurrent glioblastoma.

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Breakthroughs - brain cancer research
Using CAR-T cell immunotherapy to target glioblastomas

December 14, 2016 | Denise Heady

One of but a few centers in the United States offering human studies in CAR–T cell therapy, City of Hope is the only center investigating CAR-T cells in injection form administered directly to brain tumors.

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t cells 256
Clinical Trials Take CAR-T Therapy to Patients Who Need It

December 14, 2016 | City of Hope

City of Hope has the clinical and scientific expertise to house the entire clinical trial process on its campus — including collecting the cells, manufacturing the lentivirus, modifying and replicating the cells and reinfusing them.

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Breakthroughs - Don Diamond headshot 256x256
Study finds Triplex vaccine safe for use in healthy populations

December 14, 2016 | City of Hope

Data published in Blood supports ongoing phase 2 trial of Triplex in allogeneic hematopoietic stem cell transplant recipients.

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breakthroughs - TGen/lab photo
Alliance Brings More Firepower to the Fight Against Cancer

December 1, 2016 | City of Hope

City of Hope joins forces with the Translational Genomics Research Institute (TGen) to accelerate the speed with which scientists and clinicians can convert research discoveries into cures.

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Bart Roep
Immunologist and diabetes chair leading new clinical trial aimed at curing type 1 diabetes

September 13, 2016 | By Letisia Marquez

Bart Roep, M.D., Ph.D., chair of City of Hope’s Department of Diabetes Immunology and an internationally recognized immunologist, is leading a clinical trial that just might lead to a cure for type 1 diabetes.

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John Zaia
Gene therapy makes a potent weapon against against AIDS, cancer and more

August 11, 2016 | Jay Fernandez

This past year, leading-edge gene therapy has continued to take bold steps out of the laboratory and into the realm of potentially lifesaving treatments.

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Breakthroughs - targeting cancer cell master switch
The role of B cells to target cancer's master switch

May 9, 2016 | City of Hope

In a study published in Immunity, scientists have unlocked a key component of STAT3 activation, a gene that has long been associated with tumor cell growth and anti-tumor immune suppression.

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Marcin Kortylewski, Ph.D., Jeremy Jones, Ph.D. and Sumanta Pal, M.D.
Taking off the brakes to beat prostate cancer

March 24, 2016 | City of Hope

Researchers believe they are on the verge of significant headway in the treatment of advanced prostate cancer with a focus on immunotherapy and CAR-T cell therapy.

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