Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Liquid Biopsy Offers a New Way to Target Kidney Cancer

February 17, 2017 | Denise Heady

Despite a wave of new targeted therapies being approved to treat kidney cancer, many of those therapies have been challenging to use because of the difficulty in obtaining cancer tissue for genomic testing. Now, researchers may have found a way to combat this problem: the liquid biopsy.

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Inside the Lab: Slowing Down Estrogen Boosters to Treat Breast Cancer

February 16, 2017 | Denise Heady

City of Hope scientists have identified a new, potential treatment for breast cancers that exhibit a resistance against a common type of drug used to treat the disease.

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Markus Müschen, M.D., Ph.D., Is a Man on a Mission: Ending Childhood Leukemia

February 14, 2017 | Abe Rosenberg

Hailed as one of the best researchers of his generation, Markus Müschen has joined City of Hope with the singular goal of wiping out Acute Lymphoblastic Leukemia (ALL), the most common form of cancer in children.

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Los Angeles County Sheriff's Department Sergeant, father of four, seeks bone marrow donor

February 7, 2017 | Letisia Marquez

Los Angeles County Sheriff’s Department Sgt. Jorge Chavez is in search of a bone marrow donor for a transplant. He is battling acute myeloid leukemia.

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First, a Full Islet Transplant. Then a Baby.

February 2, 2017 | Michael Easterling

Elizabeth Jenkins, M.D., was 18 when she was diagnosed with type 1 diabetes. Today, she is the first full islet transplant recipient in the United States – and only the second woman in the world – to have had a successful pregnancy post-transplant.

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City of Hope doctor tackles two difficult-to-treat lymphomas

February 1, 2017 | Letisia Marquez

Alex F. Herrera, M.D., an assistant professor in City of Hope’s Department of Hematology & Hematopoietic Cell Transplantation, and a team of doctors at City of Hope and the Dana-Farber Cancer Institute examined how well patients whose double-hit and/or double-expressor lymphoma had recurred, or was resistant to initial treatment, fared after they had received high-dose chemotherapy and underwent an autologous stem cell transplantation.

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New Compound Discovered in the Battle Against Brain Cancer

January 30, 2017 | City of Hope

A study led by scientists at the Translational Genomics Research Institute (TGen), a City of Hope affiliate, has identified "a potent inhibitory compound" in the elusive hunt for an improved treatment against glioblastoma, the most common and deadly type of adult brain cancer.

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INSIDE THE LAB: Tracking T cells in the brain

January 27, 2017 | Denise Heady

City of Hope researchers have seen initial success treating brain cancer patients with CAR-T cell therapy, yet questions still linger about what exactly happens to these cells once they disperse through the brain. A new imaging technique may be the answer.

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Low Vaccination Rates for HPV a Serious ‘Public Health Threat’

January 11, 2017 | City of Hope

Several types of high-risk HPV are responsible for the vast majority of cervical, anal, oropharyngeal (middle throat) and other genital cancers that affect men and women. Although many of these HPV-associated cancers are preventable with a safe and effective vaccine, HPV vaccination (HPVV) rates across the U.S. remain low.

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Trial Results Point to Promising Treatments for Hodgkin Lymphoma Patients

January 9, 2017 | Abe Rosenberg

Everything changed when Hodgkin lymphoma patient Lowell Winer joined a Phase II clinical trial examining the effectiveness of brentuximab vedotin (BV) after a failed transplant. The BV worked immediately, achieving a complete remission which, year after year, proved to be durable beyond anyone's expectations.

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