Breakthroughs Blog

City of Hope has so many breakthroughs in cancer, diabetes and HIV/AIDS - and so many stories - that we've tailored our blog, Breakthroughs, to provide something for every reader. Whether the breakthroughs are about medical research, treatment advances or personal triumphs, they're all connected.

Liquid Biopsy Offers a New Way to Target Kidney Cancer

February 17, 2017 | Denise Heady

Despite a wave of new targeted therapies being approved to treat kidney cancer, many of those therapies have been challenging to use because of the difficulty in obtaining cancer tissue for genomic testing. Now, researchers may have found a way to combat this problem: the liquid biopsy.

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Inside the Lab: Slowing Down Estrogen Boosters to Treat Breast Cancer

February 16, 2017 | Denise Heady

City of Hope scientists have identified a new, potential treatment for breast cancers that exhibit a resistance against a common type of drug used to treat the disease.

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Markus Müschen, M.D., Ph.D., Is a Man on a Mission: Ending Childhood Leukemia

February 14, 2017 | Abe Rosenberg

Hailed as one of the best researchers of his generation, Markus Müschen has joined City of Hope with the singular goal of wiping out Acute Lymphoblastic Leukemia (ALL), the most common form of cancer in children.

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New in Nature: Researchers discover sugar-addiction of cancer cells in childhood leukemia

February 13, 2017 | Katie Neith

According to a new article in Nature, a team led by City of Hope’s Markus Müschen, M.D., Ph.D., Chair of the Department of Systems Biology, thinks that sugar uptake and energy supply may play a key role in the relapse of ALL.

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Peter P. Lee, M.D.: Chasing Cancer from All Angles

February 8, 2017 | Abe Rosenberg

In Peter Lee's latest project, he directs a diverse, far-flung team that's examining breast tumors' so-called “microenvironment,” or the non-cancerous cells that surround and support the tumor, and how they affect the immune system.

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New Study: Deploying Genetic Screens Early May Offer Some Benefits

February 7, 2017 | Jyoti Madhusoodanan

Next-generation sequencing (NGS) tests can quickly pinpoint tumor mutations that can be targeted with specific drugs, offering a route to precision therapies for many cancer types. Coupled with new drugs that target tumor-specific genomic changes, NGS tests carry the potential to transform modern cancer care.

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‘Within My Lifetime’: Arthur Riggs, Ph.D., and His Quest for a Diabetes Cure

February 6, 2017 | Samantha Bonar

Arthur Riggs, Ph.D., the Samuel Rahbar Chair in Diabetes & Drug Discovery and director of the Diabetes & Metabolism Research Institute at City of Hope, is rounding third in his quest for a cure for type 1 diabetes. Now, thanks to a new $50 million funding program led by the Wanek family, he is only picking up the pace.

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City of Hope doctor tackles two difficult-to-treat lymphomas

February 1, 2017 | Letisia Marquez

Alex F. Herrera, M.D., an assistant professor in City of Hope’s Department of Hematology & Hematopoietic Cell Transplantation, and a team of doctors at City of Hope and the Dana-Farber Cancer Institute examined how well patients whose double-hit and/or double-expressor lymphoma had recurred, or was resistant to initial treatment, fared after they had received high-dose chemotherapy and underwent an autologous stem cell transplantation.

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New Compound Discovered in the Battle Against Brain Cancer

January 30, 2017 | City of Hope

A study led by scientists at the Translational Genomics Research Institute (TGen), a City of Hope affiliate, has identified "a potent inhibitory compound" in the elusive hunt for an improved treatment against glioblastoma, the most common and deadly type of adult brain cancer.

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INSIDE THE LAB: Tracking T cells in the brain

January 27, 2017 | Denise Heady

City of Hope researchers have seen initial success treating brain cancer patients with CAR-T cell therapy, yet questions still linger about what exactly happens to these cells once they disperse through the brain. A new imaging technique may be the answer.

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