An NCI-designated Comprehensive Cancer Center
By City of Hope | June 25, 2019
City of Hope Orange County On the left, the newly purchased building that will anchor the City of Hope Orange County campus (pictured right)
City of Hope has accelerated its plans for a $1 billion comprehensive cancer campus in Orange County, bringing highly specialized cancer care, clinical trials, precision medicine and early detection to the nation’s sixth most populous county.
The state-of-the art campus in Irvine, California, is expected to open in 2021 — sooner than initially planned. The initiative is part of City of Hope’s commitment to speeding pioneering treatments and scientific breakthroughs to the people who need them today.
Last year, City of Hope and FivePoint Holdings, LLC, the largest developer of mixed-used, master-planned communities in coastal California, announced their partnership to build a $200 million, 73-000-square-foot cancer center in Irvine. The center, in FivePoint’s Great Park Neighborhoods, was slated to open in 2025.
As planning progressed, FivePoint and City of Hope expanded their vision for the Great Park as a model community of the future with easily accessible world-class health and wellness as a core offering. In line with this vision, City of Hope significantly increased its investment with a focus on highly specialized cancer care, research and lifesaving treatments.
Now a space as big as the vision, the cancer campus on approximately 11 acres of land will include an existing building of approximately 190,000 square feet that will be a center of innovative cancer research and treatments. This increased investment will enable the campus to open its doors by 2021.
City of Hope officials cite several reasons for an expanded presence in the region. Nearly 20% of residents leave the area for advanced care, with many heading to City of Hope’s main campus in Duarte — up to a two-hour commute away. And despite its reputation for healthy living, Orange County is not immune from the 1-in-3 national statistic for cancer incidence. In fact, the cancer incidence rate in the county is projected to increase by 18% over the next decade. Cancer risk increases with age, and the county’s population is aging faster than the U.S. average.
“We’ve spent the last year listening intently to the people in Orange County, evaluating the services needed now and in the future and identifying the gaps,” said Annette M. Walker, president of City of Hope Orange County. “It became evident that we needed to bring our highly specialized treatments as soon as possible. We’re delivering on our promise and opening our doors faster to alleviate the unnecessary hardships on patients and their families.”
The new City of Hope cancer campus will include:
  • Orange County’s only specialty hospital dedicated solely to treating and curing cancer.
  • An outpatient cancer center offering diagnostic imaging and screenings, precision medicine and early detection, medical oncology, chemotherapy, radiation therapy, surgical oncology and ambulatory surgery.
  • A clinical research center offering phase 1-3 clinical trials.
  • Personalized supportive care services that include palliative care physicians, psychiatrists, social workers and others who partner with patients and their families to address the many physical and emotional issues that can arise during and after treatment.
  • Access to a wide range of solid tumor and blood cancer specialists dedicated to finding the best treatments for each patient.   
“This is a time of great promise and innovation in cancer research and care, and we are bringing that excitement and expertise to Orange County,” said Robert Stone, president and CEO of City of Hope. “City of Hope is dramatically expanding to provide a cancer network of unparalleled scale for this community.”
The campus will be an extension of City of Hope in Duarte, providing access to highly specialized cancer experts and treatment for the most complex cases such as bone marrow transplants and CAR T cell therapy.
City of Hope’s Orange County network will include additional clinical locations, providing residents with more convenient access to our world-class care, lifesaving research, and scientific discoveries. The first site, in Newport Beach’s Fashion Island, is on track to open later this year.
“Cancer breakthroughs happen every day at City of Hope, and we’re setting the pace for translating revolutionary discoveries into life-changing treatments. Our expansion into Orange County opens a new door for residents, providing more access to our highly specialized medical expertise and the next generation of cancer cures and care,” said Michael Caligiuri, M.D., president, City of Hope National Medical Center and the Deana and Steve Campbell Physician-in-Chief Distinguished Chair in Honor of Alexandra Levine, M.D..
For updates on the initiative, go to


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