Alexandra Jacqueline Annala

Alexandra Jacqueline Annala, Ph.D.

  • Associate Research Professor, Department of Developmental & Stem Cell Biology

Alexandra Jacqueline Annala, Ph.D.

研究重點 :
  • Clinical Research
  • Oncology
  • Cell Therapy
  • Gene Therapy
  • Immunology
  • Endocrinology
  • Pharmacology
  • Radiology

Dr. Alex Annala has extensive background in government, corporate, and nonprofit organizations including executive leadership, internal consulting, fundraising, lobbying, research management, and strategic planning.

  • 2011-present, Chief Executive Officer, TheraBiologics Inc.
  • 2010-present, Associate Research Professor, Neuroscience & Stem Cells, City of Hope
  • 2006-2010, Associate Professor, Medical Physiology & Functional Imaging, Cleveland University of Kansas City & Los Angeles
  • 2005-2006, Associate Professor, Gross Anatomy & Medical Physiology, West Coast University
  • 2003-2004, Director Surgical Research, Cedars-Sinai Medical Center
  • 1997-2002, Manager Clinical Research, University of California Los Angeles
  • 1995-1997, Wellcome Trust Senior Faculty Research Fellow, University College London
  • 1986-1995, Chief Executive Officer, Annala Research Inc.
  • 1986-1987, Manager Scientific Computing, Eli Lilly and Company
  • Department of Developmental & Stem Cell Biology
  • Neuro-Oncology (CNS) Disease Team
  • Gynecologic Cancer Disease Team
  • Pediatric Hematology-Oncology / Hemophelia Disease Team
  • Developmental Therapeutics Disease Team
  • Gene Therapy Disease Team

學位

  • 1990-1995, Doctorate, Neural, Informational, and Behavioral Sciences, University of Southern California, Los Angeles, CA
  • 1987-1990, Masters, Molecular Biology, University of Southern California, Los Angeles, CA
  • 1983-1985, Masters, MBA Core & Information Sciences Core, Claremont Graduate School, Claremont, CA
Clinical Trials
  • 2012 Amendment to IRB Protocol #08002: First-in-Human NSC-Mediated CD/5-FC Treatment for Recurrent Glioma. Proposed first-in-human use of Ferumoxytol to label NSCs for MRI tracking of migration and tumor
    distribution in patients. PI: Portnow J. Co-Investigators: Annala AJ et al.
  • 2012 Amendment to IRB Protocol #04133: Hematopoietic Cell Transplantation for Hematological Malignancies: Neuropsychological Functioning After Hematopoietic Cell Transplantation. Addition of structural and functional brain imaging of patients with cognitive impairment, without cognitive impairment, and controls. PI: Bhatia S. Co-Investigators: Annala AJ et al.
  • 2007 IRB Protocol #06272007: Neurobiological Substrates of Complementary & Alternative Treatment Effects: High density electroencephalography with source localization for three dimensional imaging of brain
    functional activity to develop and validate a novel objective pain measurement system
    . PI: Annala AJ.
 
Patents
  • 2019 US Patent Issued 10,238,699. Aboody KS, Annala AJ, Curiel D, Lesniak M. Tropic Cell Based Virotherapy for the Treatment of Cancer.
  • 2019 US Patent Application 16/361,100 (Continuation) Aboody KS, Annala AJ, Curiel D, Lesniak M. Tropic Cell Based Virotherapy for the Treatment of Cancer.
  • 2019 PCT Application PCT/US19/30067 Annala AJ, Aboody KS, Fong Y, Chen N, Hammad M. Neural Stem Cell Compositions Including Chimeric Pox Viruses for Cancer Treatment.
  • 2019 US Patent Application 16/398,108. Annala AJ, Aboody KS, Hammad M, Mooney R, Covello J. Neural Stem Cell-Mediated Cancer Treatment.
  • 2013 US Patent 14/256,777. Aboody KS, Annala AJ, Mooney R, Berlin J, Weng Y. Encapsulated Diagnostics and Therapeutics in Nanoparticles Conjugated to Trophic Cells and Methods for Use. (Patent to Issue in 2019).
Metz M, Tirughana R, Li Z, Beltzer J, Annala AJ, Oganesyan D, Gutova M, Aboody KS. GMP Production and Scale-up of Therapeutic Adherent Neural Stem Cells with Quantum Cell Expansion System. Molecular
Therapy, 10:48-56, 2018. PMID: 29992178

Sahoo P, Frankel P, Ressler J, Gutova M, Annala AJ, Badie B, Portnow J, Aboody KS, D’Apuzzi N, Rockne RC. Early changes in tumor perfusion from T1-weighted dynamic contrast-enhanced MRI following neural stem cell-mediated therapy of recurrent high-grade glioma correlate with overall survival. Stem Cells International, 2018:5312426, 2018. PMID: 29731779.

Mooney R, Abdul Majid A, Batalla J, Annala AJ, Aboody KS. Cell-mediated enzyme prodrug cancer therapies. Advanced Drug Delivery Reviews, 118:35-51, 2017. PMID: 28916493.

Barish ME, Hermann K, Tang Y, Herculian SA, Metz M, Aramburo S, Tirughana R, Gutova M, Annala AJ, Moats RA, Goldstein L, Rockne RC, Gutierrez J, Brown CE, Ghoda L, Aboody KS. Human neural stem cell biodistribution and predicted tumor coverage by a diffusible therapeutic in a mouse glioma model. Stem Cells Translational Medicine, 6(6):1522-1532, 2017. PMID: 28481046

Cao P, Mooney R, Tirguhana R, Abidi W, Gilchrist M, Nwokafor U, Aramburo S, Flores L, Tiet P, Kim SU, Annala AJ, Han E, Dellinger T, Aboody KS, Berlin JM. Intraperitoneal administration of neural stem cellnanoparticle
conjugates targets chemotherapy to ovarian tumors. Bioconjugate Chemistry, 28(6):1767−1776, 2017. PMID: 28453256.

Gutova M, Goldstein L, Metz M, Hovsepyan A, Tsurkan LS, Revathiswari T, Tsaturyan L, Annala AJ, Synold T, Wan Z, Seeger R, Anderson C, Moats RA, Potter PM, Aboody KS. Optimization of a neural stem cellmediated carboxylesterase/irinotecan gene therapy for metastatic neuroblastoma. Molecular Therapy
Oncolytics, 4:67-76, 2016. PMID: 28345025.

Li Z, Oganesyan D, Mooney R, Rong X, Christensen MJ, Shahmanyan D, Perrigue PM, Benetatos J, Tsaturyan L, Aramburo S, Annala AJ, Lu Y, Najbauer J, Wu X, Barish ME, Brody DL, Aboody KS, Gutova M. L-MYC expression maintains self-renewal and prolongs multipotency of primary human neural stem cells. Stem Cell Reports, 7(3):483-95, 2016. PMID: 27546534.

Morshed RA, Gutova M, Juliano J, Barish ME, Hawkins-Daarud A, Oganesyan D, Khankaldyyan V, Yang T, Annala AJ, Ahmed AU, Aboody KS, Swanson K, Moats R, Lesniak MS. Analysis of glioblastoma tumor coverage by oncolytic virus-loaded neural stem cells using MRI-based tracking and histological reconstruction. Cancer Gene Therapy, 22(1):55-61, 2015. PMID: 25525033.

Mooney R, Roma L, Zhao D, Van Haut D, Garcia E, Kim SU, Annala AJ, Aboody KS, Berlin JM. Neural stem cell-mediated intratumoral delivery of gold nanorods improves photothermal therapy. ACS Nano, 8(12):12450-60, 2014. PMID: 25375246.

Mooney R, Weng Y, Garcia E, Bhojane S, Smith-Powell L, Kim SU, Annala AJ, Aboody KS, Berlin JM. Conjugation of pH-responsive nanoparticles to neural stem cells improves intratumoral therapy. J Control Release, 191:82-9, 2014. PMID: 24952368.

Mooney R, Weng Y, Tirughana-Sambandan R, Garcia E, Valenzuela V, Aramburo S, Annala AJ, Berlin JM and Aboody KS. Neural stem cells improve intracranial nanoparticle retention and tumour-selective distribution. Future Oncol, 10(2),401-415, 2014. PMID: 24559447.

Gutova, M, Shackleford, GM, Khankaldyyan, V, Herrmann, KA, Shi, X-H, Mittelholtz K, Abramyants, Y, Blanchard, MS, Kim, SU, Annala AJ, Najbauer, J, Synold, TW, D’Apuzzo, M, Barish, ME, Moats, RA & Aboody, KS. Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblatoma. Gene Ther, 20(2):143-150, 2013. PMID: 22402322.

Gutova M, Frank JA, D’Apuzzo M, Khankaldyyan V, Gilchrist M, Annala AJ, Metz MZ, Abramyants Y, Herrmann KA, Ghoda LY, Najbauer J, Brown CE, Lesniak MS, Barish ME, Aboody KS* and Moats RA* (*PIs Contributed equally). Magnetic resonance imaging tracking of ferumoxytol-labeled human neural stem cells: studies leading to clinical use. Stem Cells Trans Med, 2(10):766-775, 2013. PMID: 24014682.

Aboody KS, Najbauer J, Metz MZ, D’Apuzzo M, Gutova M, Annala AJ, Synold TW, Couture LA, Blanchard S, Moats RA, Garcia E, Aramburo S, Valenzuela V, Frank RT, Barish ME, Kim SU, Badie B, Portnow J. Neural stem cell-mediated enzyme/prodrug therapy for glioma: Preclinical studies. Sci Trans Med 5(184):184ra59, 2013. PMID: 23658244.

Schnarr K, Mooney R, Weng Y, Annala AJ, Aboody KS and Berlin J. Gold nanoparticle-loaded neural stem cells for photothermal ablation of cancer. Adv Healthcare Mater, 2(7):976-82, 2013. PMID: 2359270.

Zhao D, Najbauer J, Annala AJ, Garcia E, Metz MZ, Gutova M, Polewski MD, Gilchrist M, Glackin CA, Kim SU and Aboody KS. Human neural stem cell tropism to metastatic breast cancer. Stem Cells, 30(2):314-325, 2012. PMID: 22084033.

Chen PE, Errington ML, Kneussel M, Chen G, Annala AJ, Rudhard Y, Lin CY, Rast GF, Specht CG, Tigaret CM, Nassar MA, Morris RGM, Bliss TVP and Schoepfer R. Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus. Learning & Memory, 16(10):635-644, 2009. PMID: 19794189.

Wang YL, Iyer M, Annala AJ, Nguyen K and Gambhir SS. Non-invasive indirect imaging of vascular endothelial growth factor gene expression using bioluminescent imaging in transgenic mice. Phys Genomics, 24(2):173-180, 2006. PMID: 16410544.

Wang YL, Iyer M, Annala AJ, Chappell SA, Mauro VP and Gambhir SS. Noninvasive monitoring of target gene expression by imaging reporter gene expression in living animals using improved bi-cistronic vectors. J Nuclear Med, 46(4):667-74, 2005. PMID: 15809490.

Wachsmann-Hogiu S, Annala AJ and Farkas DL. Laser applications in biology and biotechnology. Webb, C. (Ed.) Handbook of Laser Technology and Applications. Bristol, UK: Institute of Physics Publishing, 2004.

Rudhard Y, Kneussel M, Nassar MA, Rast GF, Annala AJ, Chen PE, Tigaret CM, Dean I, Roes J, Gibb AJ, Hunt SP and Schoepfer R. Absence of whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. Journal of Neuroscience, 23(6):2323-32, 2003.
PMID: 12657691.

Kudo T, Fukuchi K, Annala AJ, Chatziioannou AF, Allada V, Dahlbom M, Tai YC, Inubushi M, Huang SC, Cherry SR, Phelps ME and Schelbert HR. Noninvasive measurement of myocardial activity concentrations and perfusion defect sizes in rats with a new small animal positron emission tomograph. Circulation, 106(1):118-123, 2002. PMID: 12093780.

Sun, X., Annala AJ, Barrio JR, Toyokuni T, Satyamurthy N, Namavari M, Cherry SR, Phelps ME, Herschman HR and Gambhir SS. Quantitative imaging of gene induction in living animals. Gene Ther, 8(20):1572-9, 2001. PMID: 11704818.

Yu Y, Annala, AJ, Barrio JR, Toyokuni T, Satyamurthy N, Namavari M, Cherry SR, Phelps ME, Herschman HR and Gambhir SS. Quantification of target gene expression by imaging reporter gene expression in living animals. Nat Med, 6(8):933-937, 2000. PMID: 10932234.

Kornblum HI, Araujo DM, Annala AJ, Tatsukawa KJ, Phelps ME and Cherry SR. In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET). Nat Biotech, 18(6):655-660, 2000. PMID: 10835605.

Chatziioannou A, Qi J, Moore A, Annala AJ, Nguyen K, Leahy R, Cherry SR. Comparison of 3D maximum a posteriori and filtered backprojection algorithms for high resolution animal imaging using MicroPET. IEEE Trans on Med Imaging, 19(5):507-512, 2000. PMID: 11021693.

Annala AJ. The Role of Cerebellar Cortex in Classical Conditioning of Discrete Motor Movements: Intracranial Electrical Stimulation Studies. Doctoral Dissertation, University of Southern California, Los Angeles, 1995.

Tocco G, Annala AJ, Baudry M, Thompson RF. Learning of a hippocampal-dependent conditioning task changes the binding properties of AMPA receptors in rabbit hippocampus. Behavioral and Neural Biology, 58(3):222-231, 1992. PMID: 1280948.
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