HopeSeq Heme Comprehensive

Concurrent analysis of HopeSeq HemeMutations, HopeSeq HemeFusions and HopeSeq Expressions

HopeSeq HemeMutations Gene List

Full-length mutation analysis of 135 genes:

ABL1, ARID1A, ASXL1, ATM, B2M, BCL2, BCL6, BCOR, BCORL1, BIRC3, BRAF, BTK, CALR, CARD11, CBL, CBLB, CCND1, CCND3, CD38, CD3E, CD3G, CD79A, CD79B, CDK4, CDK7, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CHD2, CRBN, CREBBP, CSF3R, CUX1, CXCR4, DDx3x, DIS3, DNMT3A, E2F1, EGFR, EP300, ETV6, EZH2, FBXW7, FGFR3 , FH, FLT3, FAM46C, FOXO1, GATA1, GATA2, GNA13, GNAS, HCK, HRAS, ID3, IDH1, IDH2, IGLL5, IKZF1, IL6, IL7R IRF4, JAK1, JAK2, JAK3, KDM6A, KIT, KMT2A, KMT2C, KMT2D, KRAS, LCK, LMO2, MAPK1, MEF2B, MGA, MIR142, MPL, MYC, MYD88, NFKB2, NOTCH1, NOTCH2, NPM1, NRAS, NTRK1, PAX5, PDCD1, PDGFRA, PHF6, PIGA, PIK3CA, PIK3CD, PIK3CG, PIK3R5, PLCG2, POT1, PRDM1, PTEN, PTK2B, PTPN11, RAD21, RB1, RFC4, RPS15, RUNX1, SETBP1, SF3B1, SMC1A, SMC3, SOCS1, SOCS6, SPI1, SRSF2, STAG2, STAT3, STAT5A, STAT5B, STAT6, SUZ12, TCF3, TET2, TNFAIP3, TP53, TP63, U2AF1, UBR5, WHSC1, WHSC1L1, WT1, XPO1, ZEB1, ZRSR2

HopeSeq HemeFusions/Expression (including acute lymphoblastic leukemia Ph-like fusions)

RNAseq NGS-based assay to detect fusions in 74 genes with most possible partners (more than 3,000 selected rearrangements)

ABL1, ABL2, ALK, BCL2, BCL6, BCL11B, BCR, BIRC3, CBFB, CDK6, CCND1, CCND3, CHD1, CHIC2, CIITA, CREBBP, CRLF2, CSF1R, DEK, DUSP22, EBF1, EIF4A1, EPOR, ERG, ETV6, FGFR1, GLIS2, IKZF1, IKZF2, IKZF3, JAK2, KAT6A, KLF2, KMT2A, MALT1, MECOM, MKL1, MLF1, MLLT4, MLLT10, MYC, MYH11, NF1, NFKB2, NOTCH1, NTRK3, NUP98, NUP214, P2PR8, P2RY8, PAG1, PAX5, PBX1, PDCD1LG2, PDGFRA, PDGFRB, PICALM, PML, PRDM16, PTK2B, RARA, RBM15, ROS1, RUNX1, RUNX1T1, SEMA6A, SETD2, STIL, TAL1, TCF3, TFG, TP63, TYK2, ZCCHC7

Expression Analysis of 48 Genes

BAALC, BAX, BCL2, BCL3, BCL6, BMPR1B, CA6, CCND1, CCND2, CCND3, CD274, CD97, CDK3, CDK4, CDK6, CHN2, CRLF2, CTLA4, DNMT3B, EGFL7, EPOR, ERG, FLT1 (VEGFR1), FLT3, FLT4 (VEGFR3), FOXP1, GPR110, IGJ, IL2RA, IRF4, KDR (VEGGFR2), LMO1, LMO2, MCL1, MECOM, MUC1, MUC4, MYC, NRXN3, PAX5, PTPN1, SEMA6A, SPARC, SPATS2L, SPRED1, TAL1, TP53INP1, WT1

 

Specimen Requirements - Molecular Hematopathology