Fusion genes are an important class of generic alterations implicated in the pathogenesis of solid tumors including lung, glioma, prostate, sarcoma, and thyroid carcinomas.  Testing for relevant fusion gene targets may provide diagnostic and prognostic information, and/or guide selection of the appropriate therapy or clinical trial. 
 
The HopeSeq Fusion Panel, a next generation sequencing assays, is designed to detect fusions in the genes listed below with any potential partnering.

HopeSeq Fusions Gene List

A next generation sequencing (NGS) based assay designed to test fusions in the following 53 genes
AKT2, AKT3, ALK, AR, ARHGAP26, AXL, BRAF, BRCA1, BRCA2, BRD3, BRD4, CDKN2A, EGFR, ERBB2, ERBB4, ERG, ESR1, ETV1, ETV4, ETV5, ETV6, EWSR1, FGFR1, FGFR2, FGFR3, FGR, LT3, INSR, JAK2, KRAS, MAML2, MAST1, MAST2, MDM4, MET, MSMB, MUSK, MYB, MYBL1, NF1, NOTCH1, NOTCH2, NOTCH4, NRG1, NTRK1, NTRK2, TRK3, NUMBL, NUTM1, PDGFRA, PDGFRB, PIK3CA, PKN1, PPARG, PRKACA, PRKACB, PRKCA, PRKCB, PTEN, RAD51B, RAF1, RB1, RELA, RET, ROS1, RSPO2, RSPO3, TERT, TFE3, TFEB, THADA, TMPRSS2


Mnemonic
NGS
 
Methodology
Insert method here
 
Performed
Mon-Fri
 
Reported
10-14 working days
 

Specimen Required

  • Patient Preparation:
  • Collect:
    • FFPE (formalin-fixed, paraffin-embedded) Block or
    • 1 H&E and 19 USS (unstained slides) at 10 microns
  • Specimen Preparation: FFPE or H&E and USS
  • Storage/Transport Temperature: Include ice pack during transport
  • Unacceptable Conditions: 
  • Remarks: 
  • Stability: Ambient:  ; Refrigerated:  ; Frozen:
 
CPT Code(s)
81455, 88381, G0452
 
Aliases
Next Generation Sequencing