A next generation sequencing (NGS) based assay designed to target the entire coding sequence of commonly mutated genes in hematologic malignancies.

HopeSeq HemeMutations Gene List

Full-length mutation analysis of 135 genes:

ABL1, ARID1A, ASXL1, ATM, B2M, BCL2, BCL6, BCOR, BCORL1, BIRC3, BRAF, BTK, CALR, CARD11, CBL, CBLB, CCND1, CCND3, CD38, CD3E, CD3G, CD79A, CD79B, CDK4, CDK7, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CHD2, CRBN, CREBBP, CSF3R, CUX1, CXCR4, DDx3x, DIS3, DNMT3A, E2F1, EGFR, EP300, ETV6, EZH2, FBXW7, FGFR3 , FH, FLT3, FAM46C, FOXO1, GATA1, GATA2, GNA13, GNAS, HCK, HRAS, ID3, IDH1, IDH2, IGLL5, IKZF1, IL6, IL7R IRF4, JAK1, JAK2, JAK3, KDM6A, KIT, KMT2A, KMT2C, KMT2D, KRAS, LCK, LMO2, MAPK1, MEF2B, MGA, MIR142, MPL, MYC, MYD88, NFKB2, NOTCH1, NOTCH2, NPM1, NRAS, NTRK1, PAX5, PDCD1, PDGFRA, PHF6, PIGA, PIK3CA, PIK3CD, PIK3CG, PIK3R5, PLCG2, POT1, PRDM1, PTEN, PTK2B, PTPN11, RAD21, RB1, RFC4, RPS15, RUNX1, SETBP1, SF3B1, SMC1A, SMC3, SOCS1, SOCS6, SPI1, SRSF2, STAG2, STAT3, STAT5A, STAT5B, STAT6, SUZ12, TCF3, TET2, TNFAIP3, TP53, TP63, U2AF1, UBR5, WHSC1, WHSC1L1, WT1, XPO1, ZEB1, ZRSR2

Mnemonic
NGS
 
Performed
Mon-Fri
 
Reported
10-14 working days
 

Specimen Required

  • Patient Preparation:
  • Collect:
    • Blood (EDTA; 3 ml minimum, 6 ml preferred)
    • Bone Marrow Aspirate (EDTA; 3 ml minimum, 6 ml preferred)
  • Specimen Preparation: Transport 6 mL whole blood (Min: 3ml)
  • Storage/Transport Temperature: Room temperature
  • Unacceptable Conditions: 
  • Remarks: 
  • Stability: Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
 
CPT Code(s)
81455, G0452
 
Aliases
Next Generation Sequencing