Germline (heritable) mutations in the p53 gene1 predispose individuals to various tumors (early onset sarcomas and breast cancer, brain tumors, adrenal cortical carcinomas, and leukemias) associated with Li-Fraumeni syndrome 2,3. Identification of p53 gene mutations in cancer patients from Li-Fraumeni syndrome or Li-Fraumeni syndrome-like4 families may permit identification of individuals at high risk for cancer in these families.
To open a printable assay summary in a new window, click the link below.
Li-Fraumeni Syndrome (p53 Gene) Mutation Analysis Assay Summary
(in portable document format (pdf) which requires Adobe® Acrobat® Reader™ to view or print; download latest version free)