PIK3CA somatic mutations have been frequently detected in advanced solid tumors. Mutations occur mainly within the helical domain (exon 9) and the kinase domain (exon 20). Roughly 20-30% of colorectal (CRC)1, and breast cancers2, 3 have been estimated to be PIK3CA positive. A significant subset of ovarian, lung, and gastric cancers have also been reported to have PIK3CA mutations1, 4. Studies have associated hotspot PIK3CA mutations with responsiveness to PI3K pathway inhibitors5, 6, 7. PIK3CA mutations have also been associated with resistance to HER2 (ERBB2) targeted therapies in HER2+ breast cancers 8, 9. For EGFR mutant lung cancers, PIK3CA mutations have been found in ~5% of cases with acquired resistance to EGFR inhibitors10.
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PIK3CA NGS Assay Summary
(Targeted analysis for 97 cancer hotspot mutations in the PIK3CA gene by next generation sequencing)
(in portable document format (pdf) which requires Adobe® Acrobat® Reader™ to view or print; download latest version free)