A completed Test Request Form (TRF) with complete billing information is required for all tests.
Clinical information (e.g. relevant clinic notes, pedigrees, other lab results) is recommended for optimal interpretation and genotype analysis for your patient.
If requesting testing for known familial mutations, a copy of the proband mutation report is recommended.
Exception: Cultured amniocytes/CVS submitted for prenatal testing must be received in the lab M/Tu/W.
Tests for Heritable Genetic Disorders
For infants, lower volume is acceptable (2-3 cc)
Patients with a hematological neoplasia, or who have had a bone marrow transplant , or peripheral stem cell transplant should not send blood (see “Saliva”)
Saliva: saliva samples collected in Oragene saliva kit
Prenatal samples: 2 T25 flasks, cultured amniocytes or CVS (at least 75%).
Keep at ambient temperature and ship by overnight courier to arrive in the
lab on M/Tu/W.
Note: Maternal cell contamination (MCC) studies are required and performed as part of the prenatal test; therefore, blood sample from Mom is also required ( if not previously tested in this lab).
TESTS PERFORMED ON TUMORS
Microsatellite Instability (MSI)
Formalin-fixed, paraffin-embedded (FFPE) tissue samples. Please submit:
- 6 slides of tumor sample (10 micron serial sections, unstained; 1 H/E stained).
- 6 slides of matched normal tissue (e.g. bordering tissue, normal lymph node(s), 10 micron unstained; 1 H/E stained).
- Blood samples (if no normal tissue available): 2 tubes (6 ccs each) in ACD (yellow top) or EDTA (lavender top) tubes
6 slides of tumor sample (10 micron serial sections, unstained; 1 H/E stained).
Test Request Form
Please contact CMDL Client Service if you would like to request a specimen collection kit or shipping label. You must include a completed Test Request Form (TRF) with every sample. If the Test Request Form (TRF) is not complete, testing WILL be delayed. The CMDL is open Monday to Friday, 7:00 am to 5:00 pm Pacific time.
Please try to schedule specimen collection to ensure delivery during these hours. If it is necessary to schedule delivery during holidays and weekends, the samples will be held until working hours. Please note that, occasionally, for samples that are received on the weekends or holidays, a second sample is requested due to DNA extraction failure.
All specimens should be shipped to:
City of Hope
1500 East Duarte Road
Duarte, CA 91010