Breast cancer research and clinical trials

At City of Hope, breast cancer clinicians and researchers collaborate extensively to develop and evaluate new therapies for better survival and quality-of-life outcomes. Our patients have access to a wide variety of clinical trials including new chemotherapy and targeted therapies, hormone therapies, novel surgical techniques, innovative radiation approaches and new prevention strategies.

These trials give current patients access to promising, leading-edge therapies and improve overall care for future patients worldwide. Visit our clinical trials page to learn more about current studies and their eligibility criteria.

Some of our current research projects include:

  • Decoding breast cancers’ resistance mechanisms to hormone therapy or chemotherapy so that they can be overcome, enhancing treatment effectiveness
  • Identifying and isolating breast cancer fighting compounds in natural products — such as mushrooms, pomegranates and blueberries
  • Studying the role of STAT3, a protein highly activated in cancer cells, in breast cancer and developing drugs that can target this protein
  • Better understanding genetic mutations and how they interact with one another and the environment to affect breast cancer risk
  • A population study involving more than 100,000 women to examine various lifestyle factors, such as diet and exercise, and their link to breast cancer risk
  • Improving genetic counseling and other support services for women with a high breast cancer risk, so they can be better informed and equipped to make decisions about prevention procedures, such as taking hormone blockers or undergoing risk-reducing surgeries
  • Studying survivorship with a focus on quality-of-life issues, prevention of cancer recurrence and, for premenopausal survivors, fertility concerns
  • Investigating breast cancer incidence and outcomes disparities among different populations and ways to reduce that disparity through outreach, education and screening efforts in underserved groups