A Pilot Study of Candidate Biomarkers and Clinical Correlates of Chronic Graft Versus Host Disease

SUMMARY

You have been asked to participate in this research study because you have had a blood or bone marrow stem cell transplantation from a sibling or unrelated donor and either have or are being monitored for development of chronic graft versus host disease (GVHD), a common complication after stem cell/bone marrow transplant.  The purpose of this study is to determine if we can identify certain proteins and other chemicals in your blood that can predict the development of chronic GVHD.  These studies may help researchers understand how chronic GVHD develops and help develop new treatments for these disorders. Your participation in this study is for an additional collection of blood for the research study during one of your routine clinical blood tests.  Information regarding your disease status will be collected from your medical records for a period of up to 5 years.

About 45 people will take part in this study.

Chronic GVHD has a major negative impact on survival of hematopoietic stem cell transplantation (HSCT) survivors. Therapies are less effective once GVHD is fully established and therefore early diagnosis is critical. No reliable GVHD markers currently exist for early diagnosis of GVHD and therefore identifying markers at an early stage of disease is critical. The goal of this study is to identify new blood markers which help diagnose chronic GVHD early.

COH Protocol Number : 15172

Principal Investigator : Pullarkat, Vinod M.D.

Sponsor : City of Hope

BRIEF ELIGIBILITY CRITERIA :

Eligible Ages : >=18

Gender : Either

Prior Chemotherapy :

Brain Metastases :

Measurable Disease :