STAT3 Signaling During Chemo-Radiation for Squamous Cell Carcinoma of the Head and Neck

SUMMARY

You have been asked to participate in this research study because you have squamous cell cancer of the head and neck.  The purpose of this study is to find out if there are proteins related to the immune system that change during treatment for head and neck cancer.  Your participation on this study is expected to last for about 7 months. 

About 9 people will take part in this study.

Research in animals has shown that factors in the immune system change during the course of radiation therapy but these results have not been confirmed in human studies. These factors have been detected in patients with head and neck cancer, but have not been studied formally while a patient is receiving chemotherapy with radiation. This study will look at the impact of radiation and chemotherapy on the human immune system.  Researchers will be looking to see if radiation therapy increases the level of proteins that have an effect on the immune system in both the blood and on the cells near the lymph nodes.   

COH Protocol Number : 14255

Principal Investigator : Sampath, Sagus M.D.

Sponsor : City of Hope

BRIEF ELIGIBILITY CRITERIA :

Eligible Ages : >=18

Gender : Either

Prior Chemotherapy :

Brain Metastases :

Measurable Disease :