Emine Gulsen Gunes, Ph.D.

800-826-4673
Emine Gulsen Gunes
Assistant Research Professor, Toni Stephenson Lymphoma Center
Research Area
Cancer Research
SLAM Family Receptors
Myeloid-derived Suppressor Cells
Tumor Microenvironment
Multiple Myeloma
Cutaneous T Cell Lymphoma
Appointments
Assistant Research Professor, Dr. Steven T. Rosen Laboratory, Toni Stephenson Lymphoma Center, Beckman Research Institute
Emine Gulsen-Gunes, Ph.D, is an assistant research professor in the laboratory of  Steven T. Rosen, Ph.D., the Morgan & Helen Chu Director's Chair of the Beckman Research Institute, at City of Hope.
 
Dr. Gunes received her B.Sc. degree in chemistry, first M.Sc. degree in biochemistry, second M.Sc. degree in medical biology, and Ph.D. degree in medical biology in 2002, 2005, 2009 and 2013 in Turkey, respectively. Before she joined Dr. Rosen's research group, she was an assistant professor in the Biomedical Engineering and Chemical Engineering Department at Munzur University, Turkey. In addition to her dissertation research, she had started another research field that is related to the development of a new diagnostic kit for select cancer types. The Scientific and Technological Research Council of Turkey granted her research project and she started to work on it at City of Hope under Dr. Rosen’s mentorship as a visiting researcher on June 2016. 
 
Over the last four years at City of Hope, she has been developing multiple projects focusing on multiple myeloma and cutaneous T cell lymphoma pathophysiology and preclinical studies. She is currently studying the role of SLAMF5 (CD84) receptor in multiple myeloma pathogenesis and response to therapy, and she received 2018 ASH abstract achievement award with this study’s preliminary data. She recently received 2019 Research Fellow Award from the Multiple Myeloma Research Foundation with her proposal focusing on advancing a human monoclonal antibody therapeutic targeting CD84 (SLAMF5) in myeloma. She is also the recipient of the 4th WCCL Young Investigator Travel Award and a member of the International Society of Cutaneous Lymphoma.
Location
Education & Experience
Degrees

  • 2013-2017, Biomedical Engineering Department and Chemical Engineering Department, Faculty of Engineering, Munzur University

  • 2009-2013, Ph.D., Medical Biology, Institute of Medical Science, Cumhuriyet University, Turkey

  • 2006-2009, M.Sc., Medical Biology, Institute of Medical Science, Cumhuriyet University, Turkey

  • 2003-2005, M.Sc., Biochemistry, Institute of Science, Gaziosmanpasa University, Turkey

  • 1998-2002, B.Sc., Chemistry, Faculty of Science, Cumhuriyet University, Turkey

Internship

  • 2017-2019, Postdoctoral Fellow, Toni Stephenson Lymphoma Center, Beckman Research Institute of City of Hope, Duarte, CA

Professional Experience

  • 2019-present, Assistant Research Professor, Toni Stephenson Lymphoma Center, Beckman Research Institute of City of Hope, Duarte, CA

  • 2015-2017, Assistant Professor, Biomedical Engineering Department and Chemical Engineering Department, Faculty of Engineering, Munzur University, Turkey

  • 2014-2015, Assistant Professor, Biomedical Engineering Department, Faculty of Engineering, Munzur University, Turkey

  • 2013-2014, Assistant Professor, Chemical Engineering Department, Faculty of Engineering, Munzur University, Turkey

  • 2011-2013, Instructor, School of Health, Munzur University, Turkey

  • 2006-2011, Research Assistant, Medical Biology Department, Faculty of Medicine, Cumhuriyet University, Turkey

Awards & Memberships
Awards

  • 2020, 4th WCCL Young Investigator Travel Award

  • 2019, MMRF Research Fellow Award

  • 2018, ASH Abstract Achievement Award

  • 2016-2017, The Scientific and Technological Research Council of Turkey (TUBITAK), International Postdoctoral Research Scholarship (TUBITAK-2219)

  • 2010, Papers which is published in the SCI journals are awarded with TÜBİTAK International Publications Encouragement Program,
    Science Olympiad of Garanti Bank, 1st Award, Cumhuriyet University

Publications

Gunes EG, Rosen ST, Querfeld C. The Role of Myeloid Derived Suppressor Cells in Cancer Immunotherapy. (Submitted to Current Opinion in Oncology on April 12, 2020.

Lewinsky H, Gunes EG, David K, Radomir L, Kramer MP, Chen J, He T-F, Bhattacharya S, Viola D, Caserta E, Troadec E, Lee P, Feng M, Keats J, Krishnan A, Michel Rosenzweig M, Cohen Y, Shevetz O, Becker-Herman S, Pichiorri F, Rosen ST, Shachar I. CD84 is a novel regulator of the immunosuppressive microenvironment in Multiple Myeloma. (Submitted to Cancer Cell on 2 April 2020)

Pozhitkov A, Krishnan A, Rosenzweig M, Pichiorri F, Gunes EGG, Buettner R, Palmer J, Keats J, Rosen ST. Glucocorticoid Receptor Expression in Multiple Myeloma Patients is a Predictor of Survival. (Submitted to Leukemia and Lymphoma on Jan 31, 2020).

Viola D, Ada A, Caserta E, Troadec E, Besi F, McDonald T, Ghoda L, Gunes EG, Sanchez JF, Khalife J, Martella M, Karanes C, Htut M, Wang X, Rosenzweig M, Chowdhury A, Sborov D, Miles RR, Yazaki PJ, Ebner T, Hofmeister CC, Forman SJ, Rosen ST, Marcucci G, Shively J, Keats JJ, Krishnan A, Pichiorri F. Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting. Leukemia (2020). https://doi.org/10.1038/s41375-020-0810-4.

Gunes EG, Lewinsky H, Viola D, Enrico E, Rosenzweig M, Htut M, Sanchez J, Buettner R, Marcucci G, Keats J, Pichiorri F, Shacha I, Rosen S. CD84: A Potential Novel Therapeutic Target in the Multiple Myeloma Microenvironment. Clinical Lymphoma Myeloma and Leukemia, Volume 19, Issue 10, Supplement, 2019, Pages e148-e149, ISSN 2152-2650, https://doi.org/10.1016/j.clml.2019.09.247.

Khalife J, Ghose J, Martella M, Viola D, Albeto Rocci A, Troadec E, Terrazas C, Satoskar AR, Gunes EG, Dona A, Sanchez JF, Bergsagel PL, Chesi M, Pozhitkov A, Rosen S, Marcucci G, Keats JJ, Hofmeister CC, Krishnan A, Caserta E, Pichiorri F. MiR-16 regulates crosstalk in NF-kB tolerogenic inflammatory signaling between myeloma cells and bone marrow macrophages. JCI Insight. 2019;4(21):e129348. https://doi.org/10.1172/jci.insight.129348.

Buettner R, Morales C, Caserta E, Troadec E, Gunes EG, Viola D, Khalife J, Li H, Keats JJ, Christofferson A, Wu X, Synold TW, Palmer J, Sanchez JF, Pozhitkov A, Vaidehi N, Marcucci G, Krishnan A, A. Rosenzweig MA, Pichiorri F, Rosen ST. Blood Advances 2019 3:1027-1032. https://doi.org/10.1182/bloodadvances.2018027227.

Viola D, Dona A, Gunes EG, Troadec E, Wu X, Branciamore S, McDonald T, Ghoda L, Streatfield A, Sanchez JF, Karanes C, Htut M, Rosenzweig M, Keats JJ, Rosen ST, Marcucci G, Krishnan A, and Pichiorri F. Immune Mediated Mechanisms of Resistance to Daratumumab. Blood 2018 132:3201; doi: https://doi.org/10.1182/blood-2018-99-117441.

Gunes EG, Lewinsky H, Viola D, Caserta E, Rosenzweig, Htut M, Sanchez JF, Buettner R, Marcucci G, Keats JJ, Krishnan A, Rosen ST, Shachar I, Pichiorri F. CD84: A Potential Novel Therapeutic Target in Multiple Myeloma. Blood 2018 132:1924; doi: https://doi.org/10.1182/blood-2018-99-119655.

Ghose J, Viola D, Terrazas C, Caserta E, Troadec E, Khalife J, Gunes EG, Sanchez J, McDonald T, Marcucci G, Kaur B, Rosenzweig M, Keats J, Rosen S, Krishnan A, Satoskar AR, Hofmeister CC, Pichiorri F. Daratumumab induces CD38 internalization and impairs myeloma cell adhesion. Oncoimmunology. 2018 Jul 23;7(10):e1486948. doi: 10.1080/2162402X.2018.1486948. eCollection 2018.

Gunes EG, Pinarbasi E. Fibroblast growth factor receptor 4 Gly388 Arg polymorphism is not associated with pre-eclampsia in Turkish women. J Obstet Gynaecol Res. 2011 Dec;37(12):1824-7. 

Pinarbasi E, Gunes EG, Pinarbasi H, Donmez G, Silig Y. AXIN2 Polymorphism and Its Association with Prostate Cancer in a Turkish Population. Med Oncol. 2011 Dec;28(4):1373-8.

Gunes EG, Pinarbasi E, Pinarbasi H. AXIN2 Polymorphism and Its Association with Astrocytoma in a Turkish Population. Molecular Medicine Reports 2010;3:705-709. 

Gunes EG, Pinarbasi E, Pinarbasi H, Silig Y. Strong association between lung cancer and the AXIN2 polymorphism. Molecular Medicine Reports 2009;2:1029-1035.