Non-small cell lung cancer, breast cancer

ERBB2 gene (HER2) somatic mutations are found in ~2% of non-small cell lung cancers (NSCLC), and up to 6% of EGFR/KRAS/ALK negative NSCLCs1. The vast majority of these are insertions within exon 20 (kinase domain) and these ERBB2 mutations do not appear to be correlated with gene amplification1. Recent studies have suggested that ERBB2 mutant tumors in NSCLC may be sensitive to certain HER2 targeted therapies (afatinib2,3, trastuzumab3).

While the majority of somatic ERBB2 alterations in breast cancer are gene amplifications, a small subset of amplification negative cases have been found to be positive for mutations on sequencing4. Preclinical studies have suggested that these may indicate specific sensitivities and resistances to current ERBB2 targeted therapies4.

To open a printable assay summary in a new window, click the link below.

ERBB2-NGS (Targeted analysis for 19 cancer hotspot mutations in the ERBB2 (HER2) gene by next generation sequencing.)
(in portable document format (pdf) which requires Adobe® Acrobat® Reader™ to view or print; download latest version free)

  1. Arcila ME, et al. Clin Cancer Res. 2012 Sep 15;18(18):4910-8.
  2. De Grève J, et al. Lung Cancer. 2012 Apr;76(1):123-7
  3. Mazières J, et al. J Clin Oncol. 2013 Jun 1;31(16):1997-2003
  4. Bose R, et al. Cancer Discov. 2013 Feb;3(2):224-37