Jeffrey Y.C. Wong, M.D.
- Chair and Professor, Department of Radiation Oncology
Jeffrey Y.C. Wong, M.D.
- Radiation Treatment for Hematologic, Genitourinary and Gastrointestinal Cancers
- Focused Ultrasound
- Radiation Oncology
- Genitourinary Cancers
- Hematologic Malignancies
- Image-Guided Intensity Modulated Radiation Therapy (IG-IMRT) / TomoTherapy
- Total Body Irradiation
“We want to make a difference not only today....but also for tomorrow, for future generations.”
For nearly 20 years, Jeffrey Y.C. Wong, M.D., has guided our Radiation Oncology department through unprecedented growth. The program now boasts the latest technologies, including image-guided intensity-modulated radiation therapy, image-guided radiation therapy, TomoTherapy, CT simulation, functional tumor imaging, radioimmunotherapy, and advanced brachytherapy technologies.
Dr. Wong is recognized for his efforts in targeted therapy using image-guided Intensity Modulated Radiotherapy (IMRT), recently applying this approach to bone marrow transplantation. He is also investigating the use of MRI to guide an ultrasound device to target and eradicate prostate cancer cells.
- 1998 - present, Chair, Department of Radiation Oncology and Radiation Research, City of Hope, Duarte, CA
- 1998 - present, Medical Director, School of Radiation Therapy Technology, City of Hope, Duarte, CA
- 1992 - 2004, Director, Division of Radiation Research, Department of Radiation Oncology, City of Hope, Duarte, CA
- Radiation Oncology
- 1981, Johns Hopkins University, Baltimore, Maryland, M.D., Medicine
- 1977, Stanford University, Palo Alto, California, B.S., Biology
- 1982 -1985, Radiation Oncology, University of California San Francisco, California
Most recent publications below, additional ones are listed here on PubMed.
Hall, MD, Schultheiss, TE, Smith, DD, Fakih, MG, Kim, J, Wong, JYC, and Chen, Y. Impact of total lymph node count on staging and survival after neoadjuvant chemoradiation therapy for rectal cancer. Ann Surg Oncol, 2015, in press.
Hall MD, Schultheiss TE, Smith DD, Tseng B P, Wong JYC. The impact of increasing dose on overall survival in prostate cancer. Radiation Oncology, 10, 2015
Hall, MD, Schultheiss, TE, Smith. DD, Nguyen, KH, Wong, JYC: Dose response for radiation cataractogenesis: a meta-regression of hematopoietic stem cell transplantation regimens. Int J Radiat Oncol Biol Phys., 91(1):22-29, 2015.
Hall, MD, Chen, Y-J, Schultheiss, TE, Pezner, RD, Stein, AS, Wong, JYC: Treatment outcomes for patients with chloroma receiving radiation therapy. J Med Imaging Radiat Oncol., 58:523-527, 2014.
Kim, J.H., Stein, A., Tsai, N.C., Schultheiss, T.E., Palmer, J., Liu, A., Rosenthal, J., Forman, S.J., Wong, J.Y.C.: Extramedullary relapse following total marrow and lymphoid irradiation in patients undergoing allogenic hematopoietic cell transplant. Int. J. Radiat. Oncol. Biol. Phys., 89(1):75-81, 2014.
Chen, X., Radany, E.H., Wong, P., Ma, S., Wu, K., Wang, B., Wong, J.Y.C.: Suberoylanilide hydroxamic acid induces hypersensitivity to radiation therapy in acute myelogenous leukemia cells expressing constitutively active FLT3 mutants. PLOS One, 8(12):1-14, 2013.
Wong, J.Y.C., Forman, S., Somlo, G., Rosenthal, J., Liu, A., Schultheiss, T., Radany, E., Palmer, J., Stein, A.: Dose escalation of total marrow irradiation with concurrent chemotherapy in patients with advanced acute leukemia undergoing allogeneic hematopoietic cell transplantation. Int. J. Radiat. Oncol. Biol. Phys., 85(1):148-156, 2013.
VanderWalde, A., Ye, W., Frankel, P., Asuncion, D., Leong, L., Luu, T., Morgan, R., Twardowski, P., Koczywas, M., Pezner, R., Paz, I.B., Margolin, K., Wong, J., Doroshow, J.H., Forman, S., Shibata, S., Somlo, G.: Long-term survival after high-dose chemotherapy followed by peripheral stem cell rescue for high-risk, locally advanced/inflammatory, and metastatic breast cancer. Biol Blood Marrow Transplant, 18:1273-1280, 2012.
Chen, X., Wong, P., Radany, E.H., Stark, J.M., Laulier, C., Wong, J.Y.C.: Suberoylanilide hydroxamic acid as a radiosensitizer through a modulation of RAD51 protein and homology-directed repair in multiple myeloma. Molecular Cancer Research, 10(8):1052-64, 2012.
Han, C., Schultheiss, T.E., Wong, J.Y.C.: Dosimetric study of volumetric modulated arc therapy fields for total marrow irradiation. Radiotherapy Oncology, 102: 315-320, 2012.
Han, C., Schiffner, D.C., Schultheiss, T.E., Chen, Y-J, Liu, A., Wong, J.Y.C.: Residual setup errors and dose variations with less-than-daily image guided patient setup in external beam radiotherapy for esophageal cancer. Radiotherapy and Oncology, 102: 309-314, 2012.
Chen, Y-J., Suh, S., Nelson, R.A., Liu, A., Pezner, R.D., Wong, J.Y.C.: Setup variations in radiotherapy of anal cancer: Advantages of target volume reduction using image-guided radiation treatment. Int. J. Radiat. Oncol. Biol. Phys., 84(1):289-295, 2012.
Sampath, S., Hitchcock, Y.J., Shrieve, D.C., Randall, L., Schultheiss, T.E., Wong, J.: Pre-operative versus post-operative radiotherapy in soft-tissue sarcoma: Multi-institutional analysis of 821 patients. Int. J. Radiat. Oncol. Biol. Phys., 81(2):498-511, 2011.
Stein, A.S., O’Donnell, M.R., Synold, T.W., Dagis, A.C., Tsirunyan, A., Nademanee, A.P., Parker, P.M., Pullarkat, V.A., Snyder, D.S., Spielberger, R.T., Wong, J.Y.C., Alvarnas, J.C., Thomas, S.H., Forman, S.J.: Phase-2 trial of an intensified conditioning regimen for allogeneic hematopoietic cell transplant for poor-risk lymphoma. Bone Marrow Transplantation, 46:1256-1262, 2011.
Henkin, R.E., Del Rowe, J.D., Grigsby, P.W., Hartford, A.C., Jadvar, H., Macklis, R.M., Parker, J.A., Wong, J.Y.C., Rosenthal, S.A.: ACR-ASTRO practice guideline for the performance of therapy with unsealed radiopharmaceutical sources. Clinical Nuclear Medicine, 36(8):e72-e80, 2011.
Chen, X., Wong, J.Y.C., Wong, P., Radany, E.H.: Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis. Molecular Cancer Research, 9:448-461, 2011.
Rosenthal, J., Wong, J., Stein, A., Qian, D., Hitt, D., Hossameldin, N., Dagis, A., Thomas, S.H., Forman, S: Phase I/II trial of total marrow and lymph node irradiation to augment reduced intensity transplant for advanced hematological malignancies. Blood, 117(1): 309-315, 2011.
Somlo, G., Spielberger, R., Frankel, P., Karanes, C., Krishnan, A., Parker, P., Popplewell, L., Sahebi, F., Kogut, N., Snyder, D., Liu, A., Schultheiss, T., Forman, S., Wong, J.Y.C.: Total Marrow Irradiation: A new ablative regimen as part of tandem autologous stem cell transplantation for patients with multiple myeloma. Clinical Cancer Research, 17: 174-182, 2011.
Sampath, S., Hitchcock, Y.J., Shrieve, D.C., Lor Randall, R., Schultheiss, T.E., Wong, J.: Radiotherapy and extent of surgical resection in retroperitoneal soft-tissue sarcoma: Multi-institutional analysis of 292 patients. J Surg Oncol., 101:345-350, 2010.
Sampath S., Schultheiss, T.E., Ryu, J.K., Wong, J.Y.C.: The role of adjuvant radiation in uterine sarcomas. Int. J. Radiat. Oncol. Biol. Phys.,76: 728-734, 2010.
Zhuang, A.H., Liu, A., Schultheiss, T.E., Wong, J.Y.C.: Dosimetric study and verification of total body irradiation using helical tomotherapy and its comparison to extended SSD technique. Medical Dosimetry, 35(4): 243-249, 2010.
- American Society for Therapeutic Radiology and Oncology (ASTRO)
- Society of Chairs of Academic Radiation Oncology Programs (SCAROP)
- American Society of Clinical Oncology (ASCO)
- Radiation Research Society (RRS)
- American Society for Blood and Marrow Transplantation