Flavia Pichiorri, Ph.D., is an associate professor in the Judy and Bernard Briskin Center for Multiple Myeloma Research within the Hematologic Malignancies and Stem Cell Transplantation Institute.
Prior to joining City of Hope, Dr. Pichiorri was Assistant Professor in the Division of Hematology at Ohio State University College of Medicine. Dr. Pichiorri graduated cum laude with her M.S. in Molecular Cell and Development Biology from the University of Rome “Tor Vergata.”. She also received her doctorate in Experimental Medicine from the University of Rome “Tor Vergata” and completed her postdoctoral training at Ohio State University in the Department of Molecular Virology, Immunology and Medical Genetics.
As a post-doctoral fellow and research scientist, Dr. Pichiorri demonstrated that microRNAs (miRNAs) are involved in the malignant transformation of plasma cells and that miRNA-dependent deregulation of critical genes contributes to multiple myeloma pathogenesis. She showed that recurrent molecular aberrations, such as p53 mutation/deletion, could affect the miRNA expression and therapeutic response of multiple myeloma cells, and that circulating miRNAs could be considered new prognostic biomarkers for multiple myeloma.
The Pichiorri lab is focused on basic and translational research in multiple myeloma.
(1) preclinical and clinical experimental therapeutics in multiple myeloma;
(2) identification of genetic and epigenetic abnormalities involved in multiple myeloma pathogenesis;
(3) understanding the physiological role of multiple myeloma-derived extracellular vesicles in modulating the tumor microenvironment and their possible use as easily accessible biomarkers for multiple myeloma patient stratification at diagnosis and resistance to therapy.