An NCI-designated Comprehensive Cancer Center

Jacob M. Berlin, Ph.D.

Associate Professor, Department of Molecular Medicine
Research Focus
  • Nanoparticle Treatments
  • Nanoparticles for Targeted Delivery and Drug Discovery
Email: [email protected]

Research Teams


City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

Publications as Senior Author:

Tiet, P., Clark, K. C., McNamara, J. O., Berlin, J. M.* "Colorimetric Detection of Staphylococcus aureus Contaminated Solutions without Purification" Bioconjugate Chem, 2017, 28, 183-193.

Mooney, R., Schena, E., Saccomandi, P., Zhumkhawala, A., Aboody, K., Berlin, J. M.* "Gold Nanorod-Mediated Near-Infrared Laser Ablation: In Vivo Experiments On Mice And Theoretical Analysis At Different Settings." Int J Hyperthermia, 2016

Ouyang, M., White, E.E., Ren, H., Guo, Q., Zhang, I., Gao, H., Yanyan, S., Chen, X., Weng, Y., Da Fonseca, A., Shah, S., Manuel, E.R., Zhang, L., Vonderfecht, S.L., Alizadeh, D., Berlin, J.M.*, Badie, B.* "Metronomic Doses of Temozolomide Enhance the Efficacy of Carbon Nanotube CpG Immunotherapy in an Invasive Glioma Model" PLOS One, 2016, 11, e0148139.

Van Haute D, Longmate JM, Berlin JM. “Controlled Assembly of Biocompatible Metallic Nanoaggregates Using a Small Molecule Crosslinker.” Adv Mater. 2015 Sep;27(35):5158-64. doi: 10.1002/adma.201501602. Epub 2015 Jul 24. PMID: 26208123

White EE, Pai A, Weng Y, Suresh AK, Van Haute D, Pailevanian T, Alizadeh D, Hajimiri A, Badie B, Berlin JM. “Functionalized Iron Oxide Nanoparticles for Controlling the Movement of Immune Cells.” Nanoscale. 2015 May 7;7(17):7780-9. doi: 10.1039/c3nr04421a. PMID: 25848983

Mooney R, Roma L, Zhao D, Van Haute D, Garcia E, Kim SU, Annala AJ, Aboody KS, Berlin JM. “Neural stem cell-mediated intratumoral delivery of gold nanorods improves photothermal therapy.” ACS Nano. 2014 Dec 23;8(12):12450-60. doi: 10.1021/nn505147w. Epub 2014 Nov 17. PMID: 25375246

Mooney R, Weng Y, Garcia E, Bhojane S, Smith-Powell L, Kim SU, Annala AJ, Aboody KS, Berlin JM. "Conjugation of pH-responsive nanoparticles to neural stem cells improves intratumoral therapy." J Control Release. 2014 Oct 10;191:82-9. doi: 10.1016/j.jconrel.2014.06.015. Epub 2014 Jun 18. PMID:24952368

White, E., Van Haute, D., Badie, B.*, Berlin, J.M.* "Colloidal Nanoparticle-Mediated Immunotherapy" Encyclopedia of Surface and Colloid Science, 2014 Accepted

Mooney, R.*, Weng, Y., Tirughana-Sambandan, R., Garcia, E., Hernandez, V., Aramburo, S., Annala, A., Berlin, J.M.*, Aboody, K. "Neural stem cells improve intracranial nanoparticle retention and tumor-selective distribution" Future Oncology 2014, 10, 401-415.

Schnarr K, Mooney R, Weng Y, Zhao D, Garcia E, Armstrong B, Annala AJ, Kim SU, Aboody KS, Berlin JM. (2013). "Gold nanoparticle-loaded neural stem cells for photothermal ablation of cancer" Adv Healthc Mater., 2(7):976-82. PMID: 23592703
- Selected for the cover

Suresh, AK., Weng, Y., Li, Z., Zerda, R., Van Haute, D., Williams, JC., Berlin, JM.(2013). "Matrix Metalloproteinase-Triggered Denuding Of Engineered Gold Nanoparticles For Selective Cell Uptake" Journal of Materials Chemistry B., 1(18):2341-2349. DOI: 10.1039/c3tb00435j
- Selected for the cover

Badie B., Berlin JM. (2013). "The future of CpG immunotherapy in cancer" Immunotherapy, 5(1):1-3. PMID: 23256791

Berlin, J.M.,* Mason, K. A.* "Nanoparticles for Selective Radioprotection of Normal Tissues" (Invited Chapter) Cancer Nanotechnology. Jan 2013, 163-168

* These authors served as equal senior authors

Mentored Publications:

You, R.; Lu, W.; Shan, M.; Berlin, J.M.; Samuel, E.L.G.; Marcano, D.C.; Sun, Z.; Sikkema, W.K.A.; Yuan, X.; Song, L.; Y Hendrix, A.Y.; Tour, J.M.; Corry, D.; Kheradmand, F. (2015). " Nanoparticulate Carbon Black In Cigarette Smoke Induces DNA Cleavage  And Th17-Mediated Emphysema" eLife.

Sahni D, Jea A, Mata JA, Marcano DC, Sivaganesan A, Berlin JM, Tatsui CE, Sun Z, Luerssen TG, Meng S, Kent TA, Tour JM. (2013). "Biocompatibility of pristine graphene for neuronal interface" J Neurosurg Pediatr., 11(5):575-83. PMID: 23473006

Bitner BR, Marcano DC, Berlin JM, Fabian RH, Cherian L, Culver JC, Dickinson ME, Robertson CS, Pautler RG, Kent TA, Tour JM. (2012). "Antioxidant carbon particles improve cerebrovascular dysfunction following traumatic brain injury" ACS Nano, 25;6(9):8007-14. PMCID: PMC3458163

Marcano DC, Bitner BR, Berlin JM, Jarjour J, Lee JM, Jacob A, Fabian RH, Kent TA, Tour JM. (2013). "Design of poly(ethylene glycol)-functionalized hydrophilic carbon clusters for targeted therapy of cerebrovascular dysfunction in mild traumatic brain injury" J Neurotrauma, 1;30(9):789-96. PMID: 22928502

Sharpe MA, Marcano DC, Berlin JM, Widmayer MA, Baskin DS, Tour JM. (2012). "Antibody-targeted nanovectors for the treatment of brain cancers" ACS Nano, 24;6(4):3114-20. PMID: 22390360

Zuhl AM, Mohr JT, Bachovchin DA, Niessen S, Hsu KL, Berlin JM, Dochnahl M, López-Alberca MP, Fu GC, Cravatt BF. (2012). "Competitive activity-based protein profiling identifies aza-?-lactams as a versatile chemotype for serine hydrolase inhibition" J Am Chem Soc. 134(11):5068-71. PMCID: PMC3326416

Daisuke S. #, Berlin J. M. #, Pham T. T, Marcano D. C., Valdecanas D. R., Zhou G., Milas L., Myers J. N., Tour J. M."Noncovalent Assembly of Targeted Carbon Nanovectors Enables Synergistic Drug and Radiation Cancer Therapy in Vivo" ACS Nano, 2012,  6, 2497-2505.

Berlin JM, Pham TT, Sano D, Mohamedali KA, Marcano DC, Myers JN, Tour JM. (2011). "Noncovalent functionalization of carbon nanovectors with an antibody enables targeted drug delivery" ACS Nano. 5(8):6643-50. PMCID: PMC3160510

Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF. (2011). "Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors" Proc Natl Acad Sci U S A. 108(17):6811-6. PMCID: PMC3084096

Berlin, J. M. #; Yu, J. #; Lu, W. #; Walsh, E. E.; Zhang, L.; Zhang, P.; Chen, W.; Kan, A. T.; Wong, M. S.; Tomson, M. B.; Tour, J. M. "Engineered Nanoparticles for Hydrocarbon Detection in Oil-Field Rocks" Energy Environ. Sci., 2011, 4, 505-509.

Berlin JM, Tour JM. (2010). "Development of novel drug delivery vehicles" Nanomedicine (Lond). 5(10):1487-9. PMID: 21143027

Berlin JM, Leonard AD, Pham TT, Sano D, Marcano DC, Yan S, Fiorentino S, Milas ZL, Kosynkin DV, Price BK, Lucente-Schultz RM, Wen X, Raso MG, Craig SL, Tran HT, Myers JN, Tour JM. (2010). "Effective drug delivery, in vitro and in vivo, by carbon-based nanovectors noncovalently loaded with unmodified Paclitaxel" ACS Nano. 4(8):4621-36. PMCID: PMC2935702

Marcano DC, Kosynkin DV, Berlin JM, Sinitskii A, Sun Z, Slesarev A, Alemany LB, Lu W, Tour JM. (2010). "Improved synthesis of graphene oxide" ACS Nano. 4(8):4806-14. PMID: 20731455

Berlin JM, Fu GC. (2008). "Enantioselective nucleophilic catalysis: the synthesis of aza-beta-lactams through [2+2] cycloadditions of ketenes with azo compounds" Angew Chem Int Ed Engl. 47(37):7048-50. PMCID: PMC2790040

Bhattacharyya KX, Akana JA, Laitar DS, Berlin JM, Sadighi JP. (2008). "Carbon-Carbon Bond Formation on Reaction of a Copper (I) Stannyl Complex with Carbon Dioxide" Organometallics. 27(12):2682-2684. DOI:10.1021/om8001729

Stewart IC, Ung T, Pletnev AA, Berlin JM, Grubbs RH, Schrodi Y. (2007). "Highly efficient ruthenium catalysts for the formation of tetrasubstituted olefins via ring-closing metathesis" Org Lett. 9(8):1589-92. PMID: 17378575

Berlin JM, Campbell K, Ritter T, Funk TW, Chlenov A, Grubbs RH. (2007). "Ruthenium-catalyzed ring-closing metathesis to form tetrasubstituted olefins" Org Lett. 9(7):1339-42. PMID: 17343392 *Featured on cover

Berlin JM, Goldberg SD, Grubbs RH. (2006). "Highly active chiral ruthenium catalysts for asymmetric cross- and ring-opening cross-metathesis" Angew Chem Int Ed Engl. 45(45):7591-5. PMID: 17054302

Funk TW, Berlin JM, Grubbs RH. (2006). "Highly active chiral ruthenium catalysts for asymmetric ring-closing olefin metathesis" J Am Chem Soc. 128(6):1840-6. PMCID: PMC2533259

# These authors contributed equally.

In The News