Joe Gold, Manufacturing Director, Center for Biomedicine and Genetics, City of Hope

Joseph Gold, Ph.D.

  • Director of Manufacturing, Center for Biomedicine and Genetics

Joseph Gold, Ph.D.

Research Focus :
  • Scientific innovations in cell, molecular and developmental biology, regenerative medicine and assay development
  • 2016 - present, Director, Manufacturing, Center for Biomedicine and Genetics, Beckman Research Institute of City of Hope, Duarte, CA
  • 2012 - 2016, Assistant Director, Translational Research, Stanford University Cardiovascular Institute
  • 2011 - 2012, Senior Director of Neurobiology and Stem Cell Therapies, Geron Corporation
  • 2007 - 2011, Senior Director of Stem Cell Biology and Research Operations, Geron Corporation
  • 2005 - 2006, Director of Stem Cell Biology and Research Operations, Geron Corporation
  • 2003 - 2004, Associate Director, Stem Cell Biology, Geron Corporation
  • 2003 - 2004, Project Leader, Cardiovascular Disease Project, Geron Corporation
  • 2001 - 2002, Group Leader, Genetic Engineering, Geron Corporation
  • 1998 - 2002, Team Leader, Embryonic Stem Cell Program, Geron Corporation
  • Center for Biomedicine & Genetics

Degrees

  • 1991, Ph.D., Cell and Developmental Biology, Harvard University, Cambridge, MA
  • 1983, BA, University of Pennsylvania, Philadelphia, PA, 1983

Fellowship

  • 10/90 - 12/95, Postdoctoral Fellow, Laboratory of Dr. Roger Pedersen, Laboratory of Radiobiology and Environmental Health, University of California at San Francisco, San Francisco, CA
  • Comparison of Magnetic Resonance Imaging and Serum Biomarkers for Detection of Human Pluripotent Stem Cell-Derived Teratomas.
  • Riegler J, Ebert A, Qin X, Shen Q, Wang M, Ameen M, Kodo K, Ong SG, Lee WH, Lee G, Neofytou E, Gold JD, Connolly AJ, Wu JC. Stem Cell Reports. 2016 Feb 9;6(2):176-87
  • Human engineered heart muscles engraft and survive long term in a rodent myocardial infarction model.  Johannes Riegler, PhD; Malte Tiburcy, MD; Antje Ebert, PhD; Evangeline Tzatzalos, PhD; Uwe Raaz, MD; Oscar J. Abilez, MD, PhD; Qi Shen, MS; Nigel G. Kooreman, MD; Evgenios Neofytou, MD; Vincent C. Chen, PhD; Mouer Wang, MD; Philip S. Tsao, PhD; Andrew J. Connolly, MD, PhD; Larry A. Couture, PhD; Joseph D. Gold, PhD; Wolfram H. Zimmermann, MD; Joseph C. Wu, MD, PhD.  Circ Res. 2015 Sep 25;117(8):720-30. 
  • Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised b-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy, Haodi Wu, Jaecheol Lee, Ludovic G. Vincent, Qingtong Wang, Mingxia Gu, Feng Lan, Jared M. Churko, Karim I. Sallam, Elena Matsa, Arun Sharma, Joseph D. Gold, Adam J. Engler, Yang K. Xiang, Donald M. Bers, and Joseph C. Wu.  Cell Stem Cell (2015), http://dx.doi.org/10.1016/j.stem.2015.04.020
  • Enabling Consistency in Pluripotent Stem Cell-Derived Products for Research and Development and Clinical Applications Through Material Standards. French, A., Bravery C., Smith J., Chandra A., Archibald P., Gold JD, Artzi N., Kim HW, Barker RW, Meissner A., Wu JC, Knowles JC, Williams D., García-Cardeña G., Sipp D., Oh S., Loring JF, Rao MS, Reeve B., Wall I., Carr AJ, Bure K., Stacey G., Karp JM, Snyder EY, and Brindley DA.  Stem Cells Transl Med  2015 Mar;4(3):217-23.
  • Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism.  Mingxia Gu, Nicholas M. Mordwinkin, Nigel G. Kooreman, Jaecheol Lee, Haodi Wu, Shijun Hu, Jared M. Churko, Sebastian Diecke, Paul Burridge, Chunjiang He, Frances E. Barron, Sang-Ging Ong, Joseph D. Gold, Joseph C. Wu.  European Heart Journal 2015 Apr 1;36(13):806-16
  • Cross talk of combined gene and cell therapy in ischemic heart disease: role of exosomal microRNA transfer.  Sang-Ging Ong, Won Hee Lee, Mei Huang, Devaveena Dey, Kazuki Kodo, Veronica Sanchez-Freire, Joseph D. Gold, Joseph C. Wu.  Circulation 2014 130: S60-S69
  • Cardiac Tissue Slice Transplantation as a Model to Assess Tissue-Engineered Graft Thickness, Survival, and Function. Johannes Riegler, Astrid Gillich, Qi Shen, Joseph D. Gold, Joseph C. Wu.  Circulation 2014 130: S77-S86. 
  • Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system
  • Ebert AD, Kodo K, Liang  P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC.  Sci. Trans. Med 24 September 2014: Vol. 6, Issue 255, p. 255ra130 
  • Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing.  Wang Y, Liang P, Lan F, Wu H, Lisowski L, Gu M, Hu S, Kay MA, Urnov FD, Shinnawi R, Gold JD, Gepstein L, Wu JC. J Am Coll Cardiol. 2014 Aug 5;64(5):451-9.
  • Chemically defined generation of human cardiomyocytes.  Burridge PW, Matsa E, Shukla P, Lin ZC, Churko JM, EbertAD, Lan F, Diecke S, Huber B, Mordwinkin NM, Abilez OA, Cui B, Gold JD, Wu JC.  Nature Methods 2014, Published online 15 June 
  • Electrical Integration of Human Embryonic Stem Cell-Derived Cardiomyocytes in a Guinea Pig Chronic Infarct Model.  Shiba Y, Filice D, Fernandes S, Minami E, Dupras SK, Biber BV, Trinh P, Hirota Y, Gold JD, Viswanathan M, Laflamme MA. J Cardiovasc Pharmacol Ther. 2014 19(4):368-381
  • Costimulation-adhesion blockade is superior to cyclosporine A and prednisone immunosuppressive therapy for preventing rejection of differentiated human embryonic stem cells following transplantation.  Huber BC, Ransohoff JD, Ransohoff KJ, Riegler J, Ebert A, Kodo K, Gong Y, Sanchez-Freire V, Dey D, Kooreman NG, Diecke S, Zhang WY, Odegaard J, Hu S, Gold JD, Robbins RC, Wu JC.  Stem Cells. 2013 Nov;31(11):2354-63
  • Returns of the living dead: therapeutic action of irradiated and mitotically inactivated embryonic stem cells.  Gold JD, Wu JC.  Circ Res. 2012 Oct 26;111(10):1250-2
  • Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts.  Yuji Shiba, Sarah Fernandes, Elina Minami, Sarah Dupras, Benjamin Van Biber, Peter Trinh Yusuke Hirota, Joseph D. Gold, Mohan Viswanathan, Michael A. Laflamme.  Nature 2012 489,322–325
  • Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming  Paul W. Burridge, Joseph D. Gold, Gordon Keller, Joseph C. Wu  Cell Stem Cell 2012,10(1): 16-28, 6 January
 
  • Phi Beta Kappa Society, University of Pennsylvania
  • Summa Cum Laude, University of Pennsylvania
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