Lu Yang

Lu Yang, Ph.D.

  • Assistant Research Professor, Department of Systems Biology

Lu Yang, Ph.D.

Lu Yang received her doctoral degree in Pharmacology from University of Louisville, Kentucky in 2010. Her research interest was initially focused on characterizing changes of renal cell gene expression and to identify potential molecular pathways involved in the development of Diabetic Nephropathy, using the OVE26 diabetic mouse model. After additional postdoctoral training in diagnostic informatics before she joined the Functional Genomics Core of the Beckman Research Institute as a staff scientist in 2012. In the core, she provided leadership role in developing in house single cell RNA-seq data analyzing algorithm and published a first-author bioinformatics paper. She was also actively involved in multiple other research projects and was listed as co-author in several high-impact papers.
Dr. Lu Yang joined the Department of System Biology in 2017 as a Research Assistant Professor. Her long-term goal in the Department of System Biology is to integrate basic biology, clinical science, sequencing technology and bioinformatics to improve research in leukemia and lymphoma, diagnostics and drug-discovery. Her recent research interest focuses on search for the potential domain of sgRNA placement which related to maximum phenotype, by interrogating the output of high-density CRISPR screening data.
Gu Y, Zhang JW, Yang L, Huang W. Stabilization of the c-Myc protein by CAMKIIγ promotes T-cell lymphoma. Cancer Cell 32: 115-128 (2017)
Chang J, Mancuso MR, Maier C, Yang L, Kuo CJ. Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nature Medicine. 23: 450-460 (2017)
Cui Q, Yang S, Yang L and Shi Y.  Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis. Nat Communications. 7: 10637 (2016)
Wang C, Yang L, Tong W. The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance. Nature Biotechnol. 32: 926-932 (2014).

Information listed here is obtained from Pubmed, a public database; City of Hope is not responsible for its accuracy.

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