Mingfeng Zhang

Mingfeng Zhang, Ph.D.

  • Staff Scientist, Department of Systems Biology

Mingfeng Zhang, Ph.D.

Research Focus :
  • Molecular mechanisms of stromal protection on B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
  • Identification and analysis of the sialoglycoproteins responsible for BCP-ALL’s survival and drug resistance
  • Optimization of therapeutics for BCP-ALL treatments
  • 2018 – present, Staff Scientist, Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA
  • 2015 – 2018, Staff Scientist, Department of Diabetes Immunology, Beckman Research Institute of City of Hope, Department of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
  • 2012 – 2015, Postdoctoral Fellow, Department of Diabetes Immunology, Beckman Research Institute of City of Hope, Department of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
  • 2008 – 2011, Associate Professor, College of Life Sciences, Fujian Normal University, Fuzhou, China
  • 2006 – 2008, Postdoctoral Fellow, Chinese Academy of Sciences, China

Degrees

  • 2005, Ph.D., Developmental Biology, East China Normal University, China
  • 2002, M.S., Animal Ecology, Fujian Normal University, China
  • 1999, B.S., Biology, Fujian Normal University, China
Zhang M, Racine JJ, Lin Q, Liu Y, Tang S, Qin Q, Qi T, Riggs AD, Zeng D. MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice. Proc Natl Acad Sci USA. 2018, 115: E2329-E2337.
 
Ni X, Song Q, Cassady K, Deng R, Jin H, Zhang M, Dong H, Forman S, Martin PJ, Chen YZ, Wang J, Zeng D. PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells. J Clin Invest. 2017; 127:1960-1977.
 
Zhang M, Lin Q, Qi T, Wang T, Chen CC, Riggs AD, Zeng D. Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into β cells in mice with reversal of diabetes. Proc Natl Acad Sci USA. 2016; 113: 650-655.
 
Jin H, Ni X, Deng R, Song Q, Young J, Cassady K, Zhang M, Forman S, Martin PJ, Liu Q, Zeng D. Antibodies from donor B cells perpetuate cutaneous chronic graft-versus-host disease in mice. Blood. 2016; 127:2249-2260.
 
Deng R, Cassady K, Li X, Yao S, Zhang M, Racine J, Lin J, Chen L, Zeng D. B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease. J Immunol. 2015; 194:560-574.
 
Racine J, Zhang M, Wang M, Morales W, Shen C, Zeng D. MHC-mismatched mixed chimerism mediates thymic deletion of cross-reactive autoreactive T cells and prevents insulitis in nonobese diabetic mice. J Immunol. 2015; 194: 407-417.
 
Wu L*, Li N*, Zhang M*, Xue SL, Cassady K, Lin Q, Riggs AD, Zeng D. MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice. Proc Natl Acad Sci USA. 2015; 112: 15994-15999. (*Co-first authors)
 
Wang M*, Racine J*, Zhang M*, Wu T, Deng R, Johnston H, Shen C, Siswanto K, Zeng D. MHC-mismatched chimerism is required for induction of transplantation tolerance in autoimmune nonobese diabetic recipients. J Immunol. 2014; 193: 2005-2015. (*Co-first authors)
 
Racine J, Wang M, Zhang M, Zeng D. Induction of mixed chimerism depletes pre-existing and de novo-developed autoreactive B cells in autoimmune NOD mice. Diabetes. 2014; 63:2051-2062.
 
Lai L, Zhang M, Song Y, Rood D. Recombinant IL-7/HGFβ hybrid cytokine enhances T cell recovery in mice following allogeneic bone marrow transplantation. PLoS One. 2013; 8:e82998.
 
Lai L, Zhang M, Goldschneider I. Recombinant IL-7/HGFβ efficiently induces transplantable murine hematopoietic stem cells. J Clin Invest. 2012; 122:3552-3562
 
Zhang M, Shi J, Huang Y, Lai L. Expression of canonical WNT/β-CATENIN signaling components in the developing human lung. BMC Dev Biol. 2012; 12: 21.
 
Zhang M, Teng H, Shi J, Zhang Y. Disruption of β-arrestins blocks glucocorticoid receptor and severely retards lung and liver development in mice. Mech Dev. 2011; 128: 368-375.
 
Wang H, Teng H, Shi J, Zhang Y, Zhang M. Progress and insight of let-7 microRNA regulating animal development. Chinese Bulletin of Life Sciences. 2011; 23:40-44.
 
Shi J, Teng H, Xiao A, Li X, Zhang M. Canonical WNT signal pathway and mammalian lung development. Chinese Bulletin of Life Sciences. 2011; 23:1283-1309.
 
Zhang M, Wang H, Teng H, Shi J, Zhang Y. Expression of SHH signaling pathway components in the developing human lung. Histochem Cell Biol. 2010; 134: 327-335.
 
Zhang M, Liu X, Zhang Y, Zhao J. Loss of β arrestin1 and β arrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice. Dev Biol. 2010; 339: 407-417.
  • American Diabetes Association
  • American Association of Immunologists
  • Endocrine Society
  • American Association of Immunologists
  • Chinese Society for Cell Biology
  • China Zoological Society
  • 2015, Helmsley Charitable Trust Abstract Award at ENDO
  • 2011, Ten best young teachers in Fujian Normal University
  • 2010, First prize skill competition of young investigator in Fujian Normal University
  • 2008, Outstanding young faculty in Fujian Normal University
Back To Top