Mingye Feng, Ph.D.
- Assistant Professor, Department of Immuno-Oncology
Mingye Feng, Ph.D.
- 2017 - present, Assistant Professor, Department of Immuno-Oncology, Beckman Research Institute of City of Hope, Duarte, CA
- 2016 - 2017, Instructor, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA
- 2011, Ph.D., Cellular and Molecular Physiology, Johns Hopkins School of Medicine, Baltimore, MD
- 2004, B.S., Biological Sciences, University of Science and Technology of China, Hefei, Anhui, China
- 2012-2016, Postdoctoral Fellowship, Damon Runyon Cancer Research Foundation
- 2011-2016, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA
The ability to escape from surveillance by the immune system is regarded as one of the essential hallmarks of cancer cells. While the functions of lymphocytes (T, B and NK cells) in tumor immunosurveillance have been studied for decades, the roles of macrophages on tumor cell elimination have only begun to be explored. Macrophages detect and eliminate tumor cells via a process of macrophage-mediated cell phagocytosis called “programmed cell removal” (PrCR). Recent studies showed that blockade of a “don't eat me” signal CD47 on malignant hematopoietic and various solid tumor cells enabled their phagocytosis by macrophages and prevented their engraftment in mice lacking T, B and NK cells, indicating a key role of macrophages in tumor surveillance and elimination. While inducing macrophage-mediated immunosurveillance holds considerable promise for the treatment of various cancers, its underlying mechanism remains largely unknown.
My laboratory is focused on three fundamental questions: First, how do macrophages recognize tumor cells and target them for phagocytosis? Second, at different stages of cancer development, do macrophages exert multiple layers of extrinsic PrCR pressure to tumor cells, and how do tumor cells react and develop self-protective mechanisms? Third, what are the intrinsic regulatory programs in macrophages that regulate their functions in PrCR?
Our overall objective is to combine in vitro and in vivo approaches to explore the underlying mechanisms of macrophage-mediated immunosurveillance and its therapeutic potential. The identification and understanding of such important mechanisms should shed light on the basic mechanisms of tumor cell immune evasion, and enable the development of novel anti-cancer immunotherapies.
- Zhu F*, Feng M*, Seita J, Luo F, Sinha R, Weissman IL. The GABA receptor GABRR1 is expressed on and functional in blood forming stem cells and megakaryocyte progenitors. In revision. (*equal contribution).
- Feng M*#, Marjon KD*, Zhu F*, Weissman-Tsukamoto R*, Levett A, Sullivan K, Kao KS, Markovic M, Bump PA, Jackson HM, Choi TS, Liu J, Gip P, Wang D, Weissman IL#. Programmed cell removal by calreticulin in tissue homeostasis and cancer. Under review. (*equal contribution, #co-corresponding author).
- Weiskopf K, Schnorr PJ, Pang WW, Chao MP, Chhabra A, Seita J, Feng M, Weissman IL. Myeloid Cell Origins, Differentiation, and Clinical Implications, Microbiol Spectr, 2016 Oct; 4(5).
- Feng M, Cheng JY, Weissman-Tsukamoto R, Volkmer JP, Ho PY, McKenna KM, Cheshier S, Zhang M, Guo N, Gip P, Mitra SS, Weissman IL. Macrophages eat cancer cell using their own calreticulin as a guide: roles of TLR and Btk, Proc Natl Acad Sci USA, 2015, Feb 2.
- Feng M, Rao R. New insights into store-independent Ca2+ entry: secretory pathway calcium ATPase in normal physiology and cancer. Int J Oral Sci, 2013 Jun; 5 (2): 71-4.
- Leitch S*, Feng M*, Muend S, Braiterman LT, Hubbard AL, Rao R. Vesicular distribution of Secretory Pathway Ca2+-ATPase isoform1 (SPCA1) and a role in manganese detoxification in liver-derived polarized cells, Biometals, 2011 Feb; 24 (1): 159-70. (*equal contribution)
- Feng M, Grice DM, Faddy HM, Nguyen N, Leitch S, Wang Y, Muend S, Kenny PA, Sukumar S, Roberts-Thomson SJ, Monteith GR, Rao R. Store-independent activation of Orai1 by SPCA2 in mammary tumors, Cell, 2010 Oct 1; 143 (1): 84-98.
- Wang X, Ye L, McKinney CC, Feng M, Maloney PC. Cysteine scanning mutagenesis of TM5 reveals conformational changes in OxlT, the oxalate transporter of Oxalobacter formigenes. Biochemistry. 2008 May 27; 47 (21): 5709-17.
- Faddy HM, Smart CE, Xu R, Lee GY, Kenny PA, Feng M, Rao R, Brown MA, Bissell MJ, Roberts-Thomson SJ, Monteith GR. Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochem Biophys Res Commun. 2008 May 9; 369 (3): 977-81.
- Xiang M, Feng M, Muend S, Rao R, A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension. Proc Natl Acad Sci USA. 2007 Nov 20; 104 (47): 18677-81.
- 2015, Damon Runyon-Dale F. Frey Award for Breakthrough Scientists, Damon Runyon Cancer Research Foundation
- 2015, K99/R00 Pathway to Independence Award, National Cancer Institute of the National Institutes of Health
- 2011, The Martin and Carol Macht Doctoral Research Award, The Johns Hopkins University, School of Medicine