Mustafa Raoof, M.D.
- Surgical Oncology
- Liver and Pancreatic Surgery
- Heated Intraperitoneal Chemotherapy (HIPEC)
- Robotic surgery for Liver and Pancreatic Tumors
- Surgery for Retroperitoneal Sarcomas and Gastrointestinal Stromal Tumors
- Surgery for Neuroendocrine Tumors
- Replication Stress and DNA damage response in Gastrointestinal Cancers
- Nanoparticles for targeted drug delivery in Peritoneal Surface Malignancies
- Immunology and immune therapies for Gastrointestinal Cancers
Becoming a physician enables you to help patients and make a difference in their lives, not just by providing high quality health care, but also by being a researcher, educator and an advocate.”
At City of Hope, Dr. Raoof is part of one of the largest programs in the region performing complex cytoreductive surgery and heated intraperitoneal chemotherapy for cancers that have disseminated within the abdominal cavity. He also has vast experience in providing all aspects of surgical care to patients whose cancer has spread to the liver.
In addition to clinical practice, Dr. Raoof conducts laboratory research focusing on DNA repair mechanisms in cancers. He is particularly interested in pancreatic cancer that has been very challenging to treat. By identifying and characterizing DNA repair processes that help cancer cells escape the toxic effects of chemotherapy, he is working to develop better targets for future therapies.
Dr. Raoof received his medical degree from Pakistan's Aga Khan University, then came to the U.S. where he continued his training at Harvard University, Yale University, MD Anderson Cancer Center and the University of Arizona. He is the author of dozens of peer-reviewed papers that have been published in leading scientific journals, including Nature, Journal of National Cancer Institute and Biomaterials. Dr. Raoof is the recipient of several honors and awards, most notably, the Conquer Cancer Foundation Merit Award from the American Society of Clinical Oncology and the Society of Thermal Medicine’s Biology Informa-Yamamoto Young Investigator Award.
Dr. Raoof’s mission is to deliver complex surgical oncology care with expertise and compassion, as well as to develop new therapies for patients with gastrointestinal cancers. To that end, he chose City of Hope for its “culture of scientific discovery that accelerates adaptation of groundbreaking treatments to clinical cancer care.”
- Gastrointestinal Cancers
- 2011- 2012, M.S. Patient-based biological research/Translational Sciences, Graduate School of Biomedical Sciences, University of Texas, Houston, TX
- 2006, Aga Khan University, MBBS, Pakistan
- 2015-2017, Complex Surgical Oncology, City of Hope, Duarte, California
- 2010-2012, Cancer Biology and Nanotechnology, MD Anderson Cancer Center, University of Texas, Houston, Texas
- 2007-2008, Immunology, Beth Isael Deaconess Medical Center, Harvard Medical School, Massachusetts
- 2009-2015, General Surgery, University of Arizona, Tucson, Arizona
- 2008-2009, General Surgery, Yale-New Haven Hospital, Yale University, New Haven, Connecticut
- 2016, General Surgery, American Board of Surgery - January 2016
- 2018, Complex General Surgical Oncology, American Board of Surgery - February 2018
Damage associated molecular patterns (DAMPS) and innate immune responses
- Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010 464(7285):104-7.
- Raoof M, Zhang Q, Itagaki K, Hauser CJ. Mitochondrial Peptides Are Potent Immune Activators That Activate Human Neutrophils Via FPR-1. Journal of Trauma-Injury Infection and Critical Care 2010 Jun 68(6):1328-32.
Multi-functional nanomaterials for cancer therapy
- Raoof M, Mackeyev Y, Cheney MA, Wilson LJ, Curley SA. Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complex. Biomaterials 2012 Apr 33(10):2952-60
- Raoof M, Corr SJ, Kaluarachchi WD, et al. Stability of antibody-conjugated gold nanoparticles in the endo-lysosomal nanoenvironment: Implications for non-invasive radiofrequency-based cancer therapy. Nanomedicine 2012 Oct 8(7):1096-105
- Raoof M, Cisneros BT, Guven A, Phounsavath S, Corr SJ, Wilson LJ, Curley, SA. Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields. Biomaterials. 2013 Feb 34(7):1862-9.
- Mackeyev Y, Raoof M, Cisneros BT, Koshkina N, Berger CS, Wilson LJ, Curley SA. Toward Paclitaxel-Fullerene Immunoconjugates as a targeted prodrug against cancer. Nanosystems: Physics, Chemistry, Mathematics. 2014 Jan 5(1):0–8
Development of a non-invasive radiofrequency-based nanohyperthermia system for cancer treatment
- Corr SJ, Raoof M, Mackeyev Y, Phounsavath S, Cheney MA, Cisneros BT, Shur M, Gozin M, McNally PJ, Wilson LJ, Curley SA. Citrate-capped gold nanoparticle electrophoretic heat production in response to a time-varying radiofrequency electric-field. J Phys Chem C Nanomater Interfaces. 2012 Nov 15 116(45):24380-24389
- Raoof M, Curley SA. Non-invasive radiofrequency-induced targeted hyperthermia for the treatment of hepatocellular carcinoma. Int J Hepatol 2011:676957.
- Raoof M, Cisneros BT, Corr SJ, Palalon F, Curley SA, Koshkina NV. Tumor selective hyperthermia induced by short-wave capacitively-coupled RF electric-fields. PLoS One. 2013 Jul 4 8(7):e68506
- Raoof M, Corr SJ, Zhu C, Cisneros BT, Kaluarachchi WD, Phounsavath S, Wilson LJ, Curley SA. Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma. Nanomedicine 2014 Aug 10(6):1121-30
DNA damage and chemotherapy resistance in liver cancer
- Raoof M, Zhu C, Cisneros BT, Liu H, Corr SJ,Wilson LJ, Curley SA. Hyperthermia inhibits homologous recombination at gemcitabine-stalled replication forks. JNCI 2014. 2014 Aug 106(8)
- American College of Surgeons
- Society of Surgical Oncology
- Americas Hepato-Pancreato-Biliary Association
- American Society of Colorectal Surgeons
- Society for the Surgery of Alimentary Tract
- American Association for Cancer Research
- 2017, American Society of Clinical Oncology Conquer Cancer Foundation Merit Award
- 2012, Young Investigator Award, Biology Informa-Yamamoto Society of Thermal Medicine