An NCI-designated Comprehensive Cancer Center
Yung Lyou in lab coat bio image

Yung Lyou, M.D., Ph.D.

Medical Oncologist
Research Focus
  • Genitourinary malignancies
Assistant Clinical Professor, Department of Medical Oncology & Therapeutics Research
Other Languages Spoken
  • Korean

Clinical Teams

Research Teams

  • Medical Oncology & Therapeutics Research
Yung Lyou, M.D., Ph.D., is an assistant clinical professor in the Department of Medical Oncology & Therapeutics Research specializing in genitourinary cancers, including bladder, prostate, and kidney cancer.
Dr. Lyou chose a career in medicine after watching several close relatives cope with cancer. “Their doctors were able to help my family through some of the most difficult times we experienced,” he recalled. “As a result, this inspired me to become a physician so that I could one day give back and help other cancer patients.”
Dr. Lyou graduated cum laude from Columbia University in New York City. Afterwards, he attended State University of New York Upstate Medical University (SUNY Upstate) in Syracuse, NY and received a combined M.D., Ph.D.. He then completed his internal medicine residency and hematology-oncology fellowship training at University of California Irvine (UCI).
Prior to City of Hope, Dr. Lyou was a staff physician in hematology-oncology at the Veterans Affairs Long Beach and on the faculty at UCI teaching fellows and residents.
Dr. Lyou’s research interests in genitourinary malignancies is focused on using precision medicine, genomics, and big data analytics to improve efficacy in current anti-neoplastic treatments. 


City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

Barber E, Lyou Y*, Mehta R, Lin E, Lane K, Parajuli R. Orbital Metastases from Breast Cancer with BRCA-2 mutation: A Case Report and Literature Review. Case Rep Oncol 2018. PMCID: PMC6031950 (* Corresponding author)
Lyou Y*, Barber E, Mehta R, Lee T, Goreal W, Parajuli R. Radiation-Associated Angiosarcoma of the Breast: A Case Report and Literature Review. Case Rep Oncol. 2018 Apr 6;11(1):216-220. doi: 10.1159/000488314. eCollection 2018 Jan-Apr. PMID: 29805371 (* Corresponding author) Fisher M., Kapur K, Soo S, Lyou Y, Schreiber S, Kim M. Disseminated  Microinfarctions With Cerebral Microbleeds. Journal of Stroke and Cerebrovascular Diseases. 2018 Jun;27(6):e95-e97. doi: 10.1016/ j.jstrokecerebrovasdis.2017.12.032. Epub 2018 Feb 1. PMID: 29395640;
Lyou Y*, Habowski AN, Chen GT, Waterman ML. Inhibition of Nuclear Wnt Signaling: Challenges of an Elusive Target for Cancer Therapy. Br J Pharmacol. 2017 Jul 28. PMID: 28752891. (*Corresponding author)
Raufi A, Jerkins J, Lyou Y*, Jeyakumar D. A patient with supraclavicular lymphadenopathy and anterior mediastinal mass presenting as a rare case of composite lymphoma:  A case report and literature review. Case Rep Oncol 2016 Dec 14;9(3):854-860. PMID:28203178 (* Corresponding author)
Sprowl-Tanio, S., Habowski AN, Pate KT, McQuade MM, Wang K, Edwards RA, Grun F, Lyou Y, and Waterman ML. 2016. Lactate/Pyruvate Transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. Cancer & Metabolism, 2016. Oct 3;4:20. PMID: 27729975
Lyou Y*, Zhao X, Nangia CS.  Pancytopenia in a patient with cystinosis secondary to myelosuppression from cystine crystal deposition: a case report. Journal of Clinical Medical Reports. 2015 Sep 17;9:205. doi: 10.1186/s13256-015-0691-8. PMID: 26377065 (* Corresponding author)
Martinez-De Luna RI, Ku RY, Lyou Y, Zuber ME.  Maturin is a novel protein required during primary neurogensis. Dev Biol. 2013 Dec 1;384(1):26-40. doi: 10.1016/j.ydbio.2013.09.028. Epub 2013 Oct 1. PMID: 24095902
Viczian AS, Solessio EC, Lyou Y, Zuber ME. Generation of functional eyes from pluripotent cells. PLoS Biol. 2009 Aug;7(8):e1000174. doi: 10.1371/ journal.pbio.1000174. Epub 2009 Aug 18. PMID: 19688031
Hiratani I, Ryba T, Itoh M, Yokochi T, Schwaiger M, Chang CW, Lyou Y, Townes TM, Schübeler D, Gilbert DM. Global reorganization of replication domains during embryonic stem cell differentiation. PLoS Biol. 2008 Oct 7;6(10):e245. doi: 10.1371/journal.pbio.0060245. PMID: 18842067
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