An NCI-designated Comprehensive Cancer Center
Zhen Chen

Zhen Bouman Chen, Ph.D.

Assistant Professor, Department of Diabetes Complications and Metabolism
Research Focus
  • Epigenetic regulation in endothelial stress response and its functional and translational relevance in cardiovascular diseases.
Email: [email protected]

Research Teams

  • Diabetes Complications and Metabolism
Zhen Bouman Chen, B.Med., Ph.D., completed her medical training in Basic Medical Sciences from Peking University Health Science Center, where she received the prize for "Best Thesis Research.” She then pursued her doctoral studies in mechanosensing and vascular biology at University of California Riverside, where she received the Joy K. Tilton Cancer Research Award and an Outstanding Achievement Award in Biomedical Sciences. After a postdoctoral fellowship at University of California San Diego, where she was jointly trained in the departments of Medicine and Bioengineering, Dr. Chen joined City of Hope as assistant professor in the Department of Diabetes Complications and Metabolism.
Dr. Chen was a finalist for an American Heart Association (AHA) Junior Investigator Award for Women and a recipient of a New Investigator Award from the American Physiological Society-Cardiovascular Section. She has served as a member on the Women Leadership Committee of the Arteriosclerosis, Thrombosis, and Vascular Biology Council of the AHA and an adjunct member for the Organizational Hub of the NIH 4D Nucleome Consortium. She has been a reviewer for AHA Scientific Sessions, Diabetes UK, and Hong Kong Research Grant Council, and a number of scientific journals, including Nature Biomedical Engineering, Circulation, Circulation Research, Arteriosclerosis, Thrombosis and Vascular Biology, and Genome Research.
Dr. Chen’s research focuses on the role of noncoding RNAs and endothelial stress response. Her studies have been supported by an AHA Postdoctoral Fellowship, a K99/R00 Career Development Award and R01 grants from National Heart, Lung and Blood Institute, as well as the Chan Zuckerberg Initiative and the Ella Fitzgerald Foundation.


City of Hope Comprehensive Cancer Center, 1500 East Duarte Road

Duarte, CA 91010

  • Tang X, Miao Y, Luo Y, Sriram K, Qi Z, Lin F-M, Gu Y, Lai C-H, Hsu C-Y, Peterson KL, Van Keuren-Jensen K, Fueger PT, Yeo GW, Natarajan R, Zhong S, Bouman Chen Z. Suppression of endothelial AGO1 promotes adipose tissue browning and improves metabolic dysfunction. Circulation. 2020.
  • Yan Z, Zhou Z, Wu Q, Bouman Chen Z, Koo E, Zhong S. Longitudinal changes of extracellular RNA in human plasma droplets correlate with clinical diagnoses of sporadic Alzheimer ’s disease. Curr Biol. 2020.
  • Chang Y-J, Wu J, Wang K-C, Huang C, Chen Z, Li Y-S, Chien S. Extracellular miR-92a mediates endothelial cell-macrophage communication. Arter Thromb Vasc Biol. 2019.
  • Wu W, Yan Z, Nguyen TC, Chen Z, Chien S, Zhong S. Mapping RNA-chromatin interactions by sequencing with iMARGI. Nat Protoc. 2019.
  • Zhou Z, Wu Q, Yan Z, Zheng H, Chen C, Liu Y, Qi Z, Calandrelli R, Chen Z, Chien S, Su HI, Zhong S. Extracellular RNA in a single droplet of human serum reflects physiologic and disease states. Proc Natl Acad Sci U S A. 2019.
  • He M, Huang T-S, Li S, Hong H-C, Chen Z, Martin M, Zhou X, Huang H-Y, Su S-H, Zhang J, Wang W-T, Kang J, Huang H-D, Zhang J, Chien S, Shyy JY. Atheroprotective Flow Upregulates ITPR3 in Vascular Endothelium via KLF4-Mediated Histone Modifications. Arterio Thromb Vasc Biol. 2019.
  • Yan Z, Huang N, Wu W, Chen W, Jiang Y, Chen J, Huang X, Wen X, Xu J, Jin Q, Zhang K, Chen Z, Chien S, Zhong S. Genome-wide colocalization of RNA-DNA interactions and fusion RNA pairs. Proc Natl Acad Sci U S A. 2019.
  • Fernando H. Biase, Qiuyang Wu, Riccardo Calandrelli, Marcelo Rivas-Astroza, Shuigeng Zhou, Zhen Chen, Sheng Zhong. Rainbow-Seq: Combining Cell Lineage Tracing with Single-Cell RNA Sequencing in Preimplantation Embryos. iScience. 2018.
  • Zhang J, Dong J, Martin M, He M, Gongol B, Marin TL, Chen L, Shi X, Yin Y, Shang F, Wu Y, Huang H-Y, Zhang J, Zhang Y, Kang J, Cespedes EM, Huang H-D, Powell F, Chen Z, Thistlethwaite PA, Yuan Z, Shyy JY. AMPK Phosphorylation of ACE2 in Endothelium Mitigates Pulmonary Hypertension. Am J Respir and Crit Care Med. 2018.
  • Lin F-M, Chien S, Chen Z. Epigenetic profiling with ultralow DNA amounts. Nat Biomed Eng. 2018
  • Miao Y, Ajami N, Huang T-S, Lin F-M, Lou C-H, Li S, Kang J, Munkacsi H, Wang Y-T, Maurya M, Gupta S, Chien S, Subramaniam S, Chen Z. Long Non-Coding RNA LEENE Promotes Chromatin Remodeling to Enhance Endothelial Nitric Oxide Synthase. Nat Comm. 2018.
  • Guo W, Liu W, Chen Z, Gu Y, Peng S, Shen L, Shen Y, Wang X, Feng G-S, Sun Y, Xu Q. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Comm. 2017.
  • Ajami NE, Gupta S, Maurya MR, Nguyen P, Li J, Shyy JY, Chen Z*, Chien S, Subramaniam S. Systems Biology Analysis of Longitudinal Functional Response of Endothelial Cells to Shear Stress. Proc Natl Acad Sci U S A. 2017.
    (*Co-corresponding author)
  • Shang F, Wang S-C, Hsu C-Y, Miao Y, Martin M, Yin Y,  Wu C-C, Wang Y-T, Wu G, Shu S, Huang H-D, Tarng D-C, Shiu Y-T, Cheung AK, Huang P-H, Chen Z*, Shyy JY. MicroRNA-92a mediates endothelial dysfunction in chronic kidney disease. J. Am. Soc. Nephrol. 2017. (*Co-corresponding author)
  • Huang T-S, Wang K-C, Quon S, Nguyen P, Chang T-Y, Chen Z, Li Y-S, Subramaniam S, Y-J Shyy JY, Chien S. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiol. Genomics. 2017.
  • Chen Z, Li S, Shyy JY, Subramaniam S, Chien S. Epigenetic Regulation: A New Frontier for Biomedical Engineers. Annu Rev Biomed Eng. 2017.
  • He M, Chen Z, Martin M, Zhang J, Sangwung P, Woo B, Tremoulet A, Shimizu C, Jain MK, Burns JC, Shyy JY. miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. Circ. Res. 2016
  • Liu W, Guo W, Shen L, Zhen C, Luo Q, Luo X, Feng G, Shu Y, Gu Y, Xu Q, Yang S. T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. Oncotarget. 2016.
  • T-Y, T-Y W, Li, Wang S-C, He M, Martin M, Zhang J, Shentu T-P, Xiao H, Kang J, Wang K-C, Chen Z, Chien S, Tsai M-D, Shyy JY. TIFA as a Crucial Mediator for NLRP3 Inflammasome. Proc Natl Acad Sci U S A. 2016.
  • Shang F, Li Z, Marin TL, Gongol B, Zhang J, Zhang J, Xiao H, Zhang Y, Chen Z, Shyy JY, Lei T. AMPK Phosphorylation of PARP1 Is Endothelium-Protective: Implications for Metformin and Telmisartan Treatment. PLoS One. 2016.
  • Chen Z*, Wen L, Martin M, Hsu C-Y, Fang L, Lin F-M, Lin T-Y, Geary MJ, Geary G, Zhao Y, Johnson DA, Chien S, Huang H-D, Miller YI, Huang P-H, Shyy JY. Oxidative stress activates endothelial innate immunity through SREBP2 transactivation of miR-92a.Circulation. 2015. (*Co-corresponding author)
  • Cooke JP, Chen Z. A Compendium on Peripheral Arterial Disease. Circ Res.2015.
  • Chen Z, Martin M, Li Z, Shyy JY. Endothelial Dysfunction: The Role of SREBP-Induced NLRP3 Inflammasome in Atherosclerosis. Curr Opin Lipid. 2014.
  • Wang X, Fang X, Zhou J, Chen Z,  Zhao B, Xiao L, Liu A, Li Y-S, Shyy JY, Youfei Guan, Shu Chien, and Nanping Wang. Shear stress activation of PXR in endothelial detoxification. Proc Natl Acad Sci U S A. 2013
  • Wen L, Chen Z, Jiang J, Zhang F, Cui X, Sun W, Geary GG, Wang Y, Johnson DA, Zhu Y, Shyy JY. Ca2+/calmodulin-dependent Protein Kinase Kinase β Phosphorylation of Sirtuin 1 in Endothelium Is Atheroprotective. Proc Natl Acad Sci U S A. 2013.
  • Xiao H,  Lu M, Yang Lin TY, Chen Z, Chen G, Wang W-C, Marin T, Shentu T-P, Wen L, Gongol B, Sun W, Liang X, Chen J, Huang H-D, Pedra J, Johnson DA, Shyy JY. SREBP2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility. Circulation. 2013.
  • Chen Z, Lai T-C, Jan Y-H, Lin F-M, Wang W-C, Xiao H, Wang Y-T, Sun W, Cui X, Li Y-S, Fang T, Zhao H, Padmanabhan C, Sun R, Wang DL, Jin H, Chau G-Y, a Huang H-D, Hsiao M, Shyy JY. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J Clin Invest. 2013.
  • Marin T, Gongol B, Chen Z, Woo B, Subramaniam S, Chien S, Shyy JY. Mechanosensitive microRNAs-Role in Endothelial Responses to Shear Stress and Redox State. Free Radic. Biol. Med. 2013.
  • Chen Z, Shentu T-P, Wen L, Johnson DA, Shyy JY. Regulation of SIRT1 by Oxidative Stress-Responsive miRNAs in the Endothelium. Antioxid Redox Signal. 2013.
  • Peng I-C, Chen Z, Sun W, Li Y-S, Marin TL, Hsu P-H, Su M-I, Cui X, Pan S, Lytle C, Johnson DA, Blaeser F, Chatila T, Shyy JY. Glucagon regulates ACC activity in adipocytes through the CaMKKβ/AMPK pathway. Am J Physiol Endocrinol Metab. 2012.
  • Chen H-Y, Lin Y-M, Chung H-C, Lang Y-D, Lin C-J, Huang J, Wang W-C, Lin F-M, Chen Z, Huang H-D, Shyy JY, Liang J-T, Chen R-H. miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4. Cancer Res. 2012.
  • Shyy JY, Chen Z, Wu W, Sun W. Shear-Stress Activation of AMPActivated Protein Kinase in Endothelial Homeostasis. Cell Mol Bioeng. 2011.
  • Chen Z, Peng I-C, Cui X, Li Y-S, Chien S, Shyy JY. Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A. 2010.
  • Chen Z, Peng I-C, Sun W, Su M-I, Hsu P-H, Fu Y, Zhu Y, DeFea K, Pan S, Tsai M-D, Shyy JY. AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633. Circ. Res. 2009.
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