An NCI-designated Comprehensive Cancer Center
Zhengshan Chen

Zhengshan Chen, M.D., Ph.D.

Assistant Research Professor, Department of Systems Biology
Research Focus
  • Acute lymphoblastic leukemia and B cell development
  • Pre-B cell receptor signaling, negative feedback signaling, transcription factors, inhibitory receptors, phosphatases
Email: [email protected]
Zhengshan Chen, M.D., Ph.D., is an assistant research professor in the Department of Systems Biology at Beckman Research Institute of City of Hope.
Dr. Chen obtained his M.D. and Ph.D. in pathology at Peking University Health Science Center in Beijing, China. During his Ph.D. studies, Dr. Chen joined the lab of Harinder Singh, Ph.D., at the University of Chicago to study transcription factors in B cell development.
As a postdoctoral fellow and later assistant researcher with Markus Müschen, M.D., Ph.D., at the University of California, San Francisco, he discovered that ITIM receptors and downstream phosphatases are necessary to balance the strength of oncogenic signaling in leukemia cells.
The interests of Dr. Chen’s research include pre-B cell receptor signaling transduction and tyrosine kinase-driven leukemia, important transcription factors involved in B cell development and leukemia transformation. In addition to his scientific work, Dr. Chen is pursuing his clinical training in pathology at USC.
  • Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 Feb 23;542(7642):479-483.
  • Wan X, Lei Y, Li Z, Wang J, Chen Z, McNutt M, Lin D, Zhao C, Jiang C, Li J, Pu Q, Su M, Wang Y, Gu J. pancreatic expression of immunoglobulin G in human pancreatic cancer and associated diabetes. Pancreas. 2015 Nov;44(8):1304-13.
  • Chen Z*, Shojaee S*, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21;521(7552):357-61.
  • Geng H*, Hurtz C*, Lenz KB*, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen WY, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Mark Ansel K, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell. 2015 Mar 9;27(3):409-25.
  • Gu J, Lei Y, Huang Y, Zhao Y, Li J, Huang T, Zhang J, Wang J, Deng X, Chen Z, Korteweg C, Deng R, Yan M, Xu Q, Dong S, Cai M, Luo L, Huang G, Wang Y, Li Q, Lin C, Su M, Yang C, Zhuang Z. Fab fragment glycosylated IgG may play a central role in placental immune evasion. Hum Reprod. 2015 Feb;30(2):380-91.
  • Buchner M, Swaminathan S, Chen Z, Muschen M. Mechanisms of pre-B-cell receptor checkpoint control and its oncogenic subversion in acute lymphoblastic leukemia. Immunol Rev. 2015 Jan;263(1):192-209.
  • Lei Y, Huang T, Su M, Luo J, Korteweg C, Li J, Chen Z, Qiu Y, Liu X, Yan M, Wang Y, Gu J. Expression and distribution of immunoglobulin G in the normal liver, hepatocarcinoma and postpartial hepatectomy liver. Lab Invest. 2014 Nov;94(11):1283-95.
  • Li J, Korteweg C, Qiu Y, Luo J, Chen Z, Huang G, Li W, Gu J. Two ultrastructural distribution patterns of immunoglobulin G in human placenta and functional implications. Biol Reprod. 2014 Nov;91(5):128.
  • Yang B, Ma C, Chen Z, Yi W, McNutt MA, Wang Y, Korteweg C, Gu J. Correlation of immunoglobulin G expression and histological subtype and stage in breast cancer. PLoS One. 2013;8(3):e58706.
  • Swaminathan S, Huang C, Geng H, Chen Z, Harvey R, Kang H, Ng C, Titz B, Hurtz C, Sadiyah MF, Nowak D, Thoennissen GB, Rand V, Graeber TG, Koeffler HP, Carroll WL, Willman CL, Hall AG, Igarashi K, Melnick A, Müschen M. BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint. Nat Med. 2013 Aug;19(8):1014-22.
  • Ma C, Wang Y, Zhang G, Chen Z, Qiu Y, Li J, Luo J, Huang B, Jiang C, Huang G, Wan X, Korteweg C, Gu J. IgG expression and its potential role in primary and metastatic breast cancers. Curr Mol Med. 2013; 13: 429-37.
  • Ramezani-Rad P, Geng H, Hurtz C, Chan LN, Chen Z, Jumaa H, Melnick A, Paietta E, Carroll WL, Willman CL, Lefebvre V, Müschen M. SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia. Blood. 2013 Jan 3;121(1):148-55
  • Niu N, Zhang J, Huang T, Sun Y, Chen Z, Yi W, Korteweg C, Wang J, Gu J. IgG expression in human colorectal cancer and its relationship to cancer cell behaviors. PLoS One. 2012;7(11):e47362.
  • Liu Y, Chen Z, Niu N, Chang Q, Deng R, Korteweg C, Gu J. IgG gene expression and its possible significance in prostate cancers. Prostate. 2012 May 1;72(6):690-701.
  • Zhang L, Hu S, Korteweg C, Chen Z, Qiu Y, Su M, Gu J. Expression of immunoglobulin G in esophageal squamous cell carcinomas and its association with tumor grade and Ki67. Hum Pathol. 2012 Mar;43(3):423-34.
  • Qiu Y, Korteweg C, Chen Z, Li J, Luo J, Huang G, Gu J. Immunoglobulin G expression and its colocalization with complement proteins in papillary thyroid cancer. Mod Pathol. 2012 Jan;25(1):36-45.
  • Zhao Y, Liu Y, Chen Z, Korteweg C, Gu J. Immunoglobulin G (IgG) expression in human umbilical endothelial cells. J Histochem Cytochem. 2011 May;59(5):474-88.
  • Chen Z, Xiao Y, Zhang J, Li J, Liu Y, Zhao Y, Ma C, Luo J, Qiu Y, Huang G, Korteweg C, Gu J. Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells. PLoS One. 2011;6(5):e20475.
  • Chen Z, Li J, Xiao Y, Zhang J, Zhao Y, Liu Y, Ma C, Qiu Y, Luo J, Huang G, Korteweg C, Gu J. Immunoglobulin G locus events in soft tissue sarcoma cell lines. PLoS One. 2011;6(6):e21276.
  • Chen Z, Huang X, Pan P, Ye J, Cao Q, Yang B, Li Z, Su M, Huang C, Gu J. Immunoglobulin G expression is found in a wide variety of benign and malignant soft tissue tumors and shows correlation with proliferation markers. Cancer. 2010 Apr 15;116(8):1953-63
  • Chen Z, Qiu X, Gu J. Immunoglobulin expression in non-lymphoid lineage and neoplastic cells. Am J Pathol. 2009 Apr;174(4):1139-48.
  • Cao Q, Yu C, Xue R, Hsueh W, Pan P, Chen Z, Wang S, McNutt M, Gu J. Autophagy induced by suberoylanilide hydroxamic acid in Hela S3 cells involves inhibition of protein kinase B and up-regulation of Beclin 1. Int J Biochem Cell Biol. 2008;40(2):272-83.
  • Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008 Aug;9(8):927-36.
  • Chang Q, Chen Z, You J, McNutt MA, Zhang T, Han Z, Zhang X, Gong E, Gu J. All-trans-retinoic acid induces cell growth arrest in a human medulloblastoma cell line. J Neurooncol. 2007 Sep;84(3):263-7.
  • Chen Z, Gu J. Immunoglobulin G expression in carcinomas and cancer cell lines. FASEB J. 2007 Sep;21(11):2931-8.
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