An NCI-designated Comprehensive Cancer Center
Kadriye Nehir

Kadriye Nehir Cosgun, Ph.D.

Postdoctoral Fellow, Department of Systems Biology
Research Focus
  • Role of β-catenin signaling in positive B cell selection
  • Role of pre-BCR signaling in malignant transformation of B cells
  • In vivo analysis of human hematopoiesis
Email: [email protected]

Xiao G, Chan L, Klemm L, Braas D, Chen Z, Geng H, Chen Q, Aghajanirefah A, Cosgun KN, Sadras T, Lee J, Mirzapoiazova T, Salgia R, Ernst T, Hochhaus A, Jumaa H, Jiang X, Weinstock D, Graeber T, Müschen M. B-lymphoid transcriptional repression of the pentose phosphate pathway reveals a unique therapeutic vulnerability of B cell malignancies, Cell, 2018.

Chan, LN, Z Chen, Braas D, Lee J-W, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sanchez-Garcia I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Metabolic gatekeeper function of B-lymphoid transcription factors., Nature, 2017.

Shojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH,, Dühren von Minden M, Ernst M, Andreas Hochhaus, Cazzaniga G, Melnick A, Kornblau SM, Graeber TG, Wu H, Jumaa H, Müschen M. PTEN opposes negative selection and enables oncogenic transformation of pre-B cells, Nature Medicine, 2016.

Daenthanasanmak A*, Salguero G*, Waskow C, Cosgun KN, Guzman C, Riese P, Macke L, Schneider A, Sundarasetty BS, Ingendoh A, Messerle M, Gabaev I, Woelk B, Figueiredo C, Eiz-Vesper B, von Kaisenberg C, Ganser A, Stripecke R. Genetically induced dendritic cells promote thymic and extra-thymic T cell development and HCMV-specific human CTL and IgG after humanized stem cell transplantation, Molecular Therapy, 2015.

Cosgun KN*, Rahmig S*, Mende N, Petzold A, Schmitz M, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar A, Platz A, Bornhäuser M, Roers A, Dudziak D, Kirberg J, Waskow C. Kit regulates HSC engraftment across the mouse human species barrier under steady-state conditions, Cell Stem Cell, 2014 (*equal contribution).

Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells, J. Exp. Med, 2014.

von Bonin M, Wermke M, Cosgun KN, Thiede C, Bornhauser M, Wagemaker G, Waskow C. In vivo expansion of co-transplanted T cells impacts on tumor reinitiating activity of human acute myeloid leukemia in NSG mice, Plos One, 2013.

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