Lei Gao, Ph.D.

Postdoctoral Fellow

Research Area

Generation of Transgenic Mice

Mechanism of Tumorigenesis

Lei Gao received his Ph.D. degree from Beijing Normal University in Biochemistry and Molecular Biology. During his studies, he received training for transgenic mice generation and generated cl-tTA transgenic mice with a technology called functionally enriched ES cell transgenics (FEEST), which is a highly efficient technique used to guarantee expression of the gene of interest. While doing cancer research, he found that GATA4 functioned as a tumor suppressor gene in lung cancer. His current project is focused on the study of RNA modification in cancer.

Education & Experience

Degrees

2018, Ph.D., Beijing Normal University, China, School of Life Sciences
2013, M.S., Beijing, College of Animal Science & Technology, University of Agriculture, China

2010, B.S. , Yangzhou University, China, College of Veterinary medicine

Professional Experience

2019-2021, Postdoctoral Fellow, Department of Systems Biology, City of Hope, Monrovia, CA
2018, Postdoctoral Fellow, Department of Pathology & Genomic Medicine, Methodist Hospital, Houston, Texas

Awards & Memberships

Awards

2016-2017, First Prize Scholarship, Beijing Normal University
2015-2016, National Scholarship, Beijing Normal University

Publications

Gao L, Jiang Y, Mu L, Liu Y, Wang F, Wang P, Zhang A, Tang N, Chen T, Luo M, Yu L, Gao S, Chen L. Efficient Generation of Mice with Consistent Transgene Expression by FEEST, Sci Rep. 2015, 5:16284; doi: 10.1038/srep16284
Xu N, Fang W, Mu L, Tang Y, Gao L, Ren S, Cao D, Zhou L, Zhang A, Liu D, Zhou C, Wong K, Yu L, Zhang L, Chen L, Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer. Oncotarget, 2015 Dec 4. doi: 10.18632/oncotarget.6461