Colloquium Agenda

Monday, November 6

7:30-8:30 a.m. | Breakfast

Welcome and Introduction to the Colloquium Theme

8:30-9:00 a.m. | Ravi Salgia, M.D.

Session 1: Plasticity and Evolution

Chairperson: Atish Mohanty, Ph.D.

9:00-9:30 a.m. | Gunter Wagner
“The stromal biology regulating cancer malignancy between species.”

9:30-10:00 a.m. | Carlo Maley

10:00-10:30 a.m. | Susan Rosenberg
“The DNA Damageome and Cancer Evolvability”

10:30-11 a.m. - Coffee break

Chairperson: Swapnil Rajurkar, M.D.

11:00-11:30 a.m. | Eugene Koonin
“Coevolution of mobile genetic elements and defense systems: a generator of evolutionary plasticity.”

11:30-12:00 p.m | Aurora Nedelcu
“Stress-induced plastic responses in the evolution of multicellularity and cancer”

12:00-12:30 Panel Discussion

12:30 -2:00 p.m. Lunch break

Session 2: Genetic/Non-genetic Mechanisms Underlying Plasticity

Chairperson: Sudarsan Kollimuttathuillam, M.D.

2:00-2:30 p.m. | Sui Huang
“Non-genetic State transitions in Cancer cells, the Good and Bad - from Theory to Treatment”

2:30-3:00 p.m. | Robert Gatenby
“A tale of two tumors: the evolutionary arcs from normal to malignant phenotypes in breast and lung cancers”

3:00-3:30 p.m. | Trevor A. Graham
“Mechanisms of phenotype adaptation in colorectal cancer”

3:30-4:00 p.m. Coffee break

Chairperson: Jingran Ji

4:00-4:30 p.m. | Jianjun Chen
“RNA Modification in Cancer”

4:30-5:00 | Subhajyoti De
“Transcriptional state dynamics in urothelial bladder carcinoma”

5:00-5:30 p.m. Panel discussion

Tuesday, November 7

7:30-8:30 a.m. | Breakfast

Session 3: Mathematical Modeling of Plasticity

Chairperson: Neel Talwar, M.D.

8:30-9:00 a.m. | Herbert Levine
“Epigenetic modulation of epithelial-mesenchymal plasticity"

9:00-9:30 a.m. | Robert Austin

9:30-10:00 a.m. | Mohit Kumar Jolly
“Systems-level analysis of phenotypic switching in melanoma: from design principles to therapeutic interventions”

10:00-10:30 a.m. Coffee break

Chairperson: Tanyanika Phillips

10:30-11:00 | Michael Elowitz
“The many-to-many protein interaction architecture and multicellularity”

11:00-11:30 | Supriyo Bhattacharya
“Phenotypic switching: A strategy for reversible and rapid adaptation to therapeutic stress”

11:30-12:00 Panel discussion

12:00-12:30 p.m. Group photo

12:30-1:30 p.m. Lunch

Session 4: Conformational Dynamics and Plasticity

Chairperson: Gagandeep Brar, M.D.

1:30-2:00 p.m. | Jasmine Foo
“Modeling plasticity-driven drug resistance evolution”

2:00-2:30 p.m. | Emma Lundberg
“Proteome-wide studies of cell heterogeneity”

2:30-3:00 | John Orban
"Structural plasticity in proteins"

3:00-3:30 Coffee break

Chairperson: Edward Wang

3:30-4:00 p.m. | Tsui-Fen Chou

4:00-4:30 p.m. | Shasha Chong
"Illuminating dark proteome-mediated transcriptional control in cancer by live-cell single-molecule imaging"

4:30-5:00 p.m. Panel discussion

Concluding Remarks and Thanks

5:00-5:15 p.m. | Prakash Kulkarni