Colloquium Agenda
Monday, November 4
7:00-8:15 AM Breakfast
Welcome and Introduction to the Colloquium Theme
8:15-8:25 | Ravi Salgia
8:25-8:35 | Paul Sternberg
Opening remarks
8:35-9:00 | Prakash Kulkarni
Session 1: Conformation-based phenotypic switching, and transgenerational information transfer
Chairperson: Tingting Tan
09:00-09:30 AM | Ken Dill, Survival of the Fittest: Is it a principle or a process?
09:30-10:00 AM | Peter Wright, Regulation and dysregulation of cellular processes by intrinsically disordered proteins
10:00-10:30 | John Orban, Protein metamorphism
10:30-11:00 AM Coffee break
Chairperson: Mohit Jolly
11:00-11:30 AM | Daniel Jarosz, Protein folding sculpting evolutionary change
11:30 AM-12:00 PM | Shasha Chong, Dark proteome-mediated transcriptional control in cancer at single-molecule resolution
12:00-12:30 PM | Panel discussion
12:30-1:00 PM | Group Photo
01:00-2:00 PM Lunch break
Session 2: Tolerance, resistance, persistence, and dormancy – multiple trajectories to evading drug effects (bet-hedging)
Chairperson: Animesh Ray
2:00-2:30 PM | Atish Mohanty, Drugging the Undruggable: What Comes Next—Resistance or Tolerance?
2:30-3:00 PM | Mohit Kumar Jolly, What does not kill cancer can make it stronger – mechanism-based modeling of drug-induced cell-state transitions
3:00-3:30 PM | Amy Brock, Tracking clonal trajectories reveals diversity and complexity within cell populations
3:30-4:00 PM | Coffee break
Chairperson: Sudarsan Kollimuttathuillam
4:00-4:30 PM | Matt Thomson
4:30-5:00 PM | Supriyo Bhattacharya, Conformational plasticity of the disordered protein Paxillin and its interaction with the Focal Adhesion Kinase
5:00-5:30 PM | Panel discussion
Tuesday, November 5
7:30 - 8:30 AM | Breakfast
Session 3: Phenotypic switching and group behaviour
Chairperson: David Chen
8:30-9:00 AM | Uri Alon, Systems medicine and physiological circuits
9:00-9:30 AM | Jose Onuchic
9:30-10:00 AM | Karen Page, Evolution of cooperation in an epithelium
10:00-10:30 AM | Coffee break
Chairperson: Sui Huang
10:30-11:00 AM | Michael Elowitz, Many-to-Many Networks: Multifunctional Modules for Multicellularity
11:00-11:30 AM | Hilary Coller, The Phenotypic Plasticity of Cellular Quiescence
11:30-12:00 PM | Panel discussion
12:00-1:30 PM | Lunch break
Session 4: Cancer and evolution
Chairperson: Shasha Chong
1:30-2:00 PM | Sui Huang, EVOLUTION IN CANCER and CANCER IN EVOLUTION - a broader perspective considering non-Darwinian (Waddingtonian) mechanisms
2:00-2:30 PM | Eric Miska, The genetics and epigenetics of inheritance, adaptation and evolution
2:30-3:00 PM | Marianne Bronner, Gene regulatory analysis of enteric nervous system formation
3:00-3:30 PM | Coffee break
Chairperson: Martin Sattler
3:30-4:00 PM | Yibin Kang, Cellular plasticity in the development of bone metastasis
4:00-4:30 PM | Aritro Nath, Targeting alternate growth signaling mechanisms to overcome therapeutic resistance in estrogen-receptor positive breast cancers
4:30-5:00 PM | Panel discussion
Concluding Remarks and Thanks
5:00-5:10 PM | Tsui-Fen Chou