Colloquium Agenda

Monday, November 4

7:00-8:15 AM  Breakfast

Welcome and Introduction to the Colloquium Theme

8:15-8:25 | Ravi Salgia 

8:25-8:35 | Paul Sternberg

Opening remarks

8:35-9:00 | Prakash Kulkarni

Session 1: Conformation-based phenotypic switching, and transgenerational information transfer

Chairperson:  Tingting Tan

09:00-09:30 AM | Ken Dill, Survival of the Fittest:  Is it a principle or a process?

09:30-10:00 AM | Peter Wright, Regulation and dysregulation of cellular processes by intrinsically disordered proteins

10:00-10:30 | John Orban, Protein metamorphism

10:30-11:00 AM Coffee break

Chairperson: Mohit Jolly

11:00-11:30 AM | Daniel Jarosz, Protein folding sculpting evolutionary change

11:30 AM-12:00 PM | Shasha Chong, Dark proteome-mediated transcriptional control in cancer at single-molecule resolution

12:00-12:30 PM | Panel discussion

12:30-1:00 PM | Group Photo

01:00-2:00 PM Lunch break

Session 2: Tolerance, resistance, persistence, and dormancy – multiple trajectories to evading drug effects (bet-hedging)

Chairperson: Animesh Ray

2:00-2:30 PM | Atish Mohanty, Drugging the Undruggable: What Comes Next—Resistance or Tolerance?

2:30-3:00 PM | Mohit Kumar Jolly, What does not kill cancer can make it stronger – mechanism-based modeling of drug-induced cell-state transitions

3:00-3:30 PM |  Amy Brock, Tracking clonal trajectories reveals diversity and complexity within cell populations

3:30-4:00 PM | Coffee break

Chairperson: Sudarsan Kollimuttathuillam

4:00-4:30 PM | Matt Thomson

4:30-5:00 PM | Supriyo Bhattacharya, Conformational plasticity of the disordered protein Paxillin and its interaction with the Focal Adhesion Kinase 

5:00-5:30 PM | Panel discussion

Tuesday, November 5

7:30 - 8:30 AM | Breakfast 

Session 3: Phenotypic switching and group behaviour

Chairperson: David Chen

8:30-9:00 AM | Uri Alon, Systems medicine and physiological circuits

9:00-9:30 AM | Jose Onuchic

9:30-10:00 AM | Karen Page, Evolution of cooperation in an epithelium

10:00-10:30 AM  | Coffee break

Chairperson: Sui Huang

10:30-11:00 AM | Michael Elowitz, Many-to-Many Networks: Multifunctional Modules for Multicellularity

11:00-11:30 AM | Hilary Coller, The Phenotypic Plasticity of Cellular Quiescence

11:30-12:00 PM | Panel discussion

12:00-1:30 PM | Lunch break

Session 4: Cancer and evolution

Chairperson: Shasha Chong

1:30-2:00 PM | Sui Huang, EVOLUTION IN CANCER and CANCER IN EVOLUTION - a broader perspective considering non-Darwinian (Waddingtonian) mechanisms

2:00-2:30 PM | Eric Miska, The genetics and epigenetics of inheritance, adaptation and evolution

2:30-3:00 PM | Marianne Bronner, Gene regulatory analysis of enteric nervous system formation

3:00-3:30 PM  | Coffee break

Chairperson: Martin Sattler

3:30-4:00 PM | Yibin Kang, Cellular plasticity in the development of bone metastasis

4:00-4:30 PM | Aritro Nath, Targeting alternate growth signaling mechanisms to overcome therapeutic resistance in estrogen-receptor positive breast cancers

4:30-5:00 PM | Panel discussion

Concluding Remarks and Thanks

5:00-5:10 PM | Tsui-Fen Chou