City of Hope, NatureWise announce license agreement for new targeted cancer therapy

September 29, 2016

City of Hope
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NatureWise will commercially develop HDAC8 inhibitors patented by City of Hope, collaborators

DUARTE, Calif. — City of Hope today announced that it has licensed its HDAC8 inhibitors patent exclusively to NatureWise Biotech & Medicals Corporation, a pharmaceutical company in Taipei, Taiwan.

HDAC8 is a subtype of histone deacetylase enzyme that is shown to be important in tumorigenesis, or new tumor production, most notably in acute myeloid leukemia. City of Hope and Taiwanese researchers developed a group of novel small molecules that inhibit HDAC8 and could help halt cancerous cells’ proliferation.

In recent years, HDAC inhibitors have emerged as promising targeted therapies in the fight against cancer.

“City of Hope looks forward to a productive partnership with NatureWise, and we are hopeful it will result in new and effective targeted cancer therapies,” said George Megaw, Ph.D., director of the Office of Technology Licensing in the Beckman Research Institute of City of Hope. “We are constantly in pursuit of sharing our knowledge and discoveries to advance cancer research and treatment worldwide.”

“NatureWise is a leader in the development of HDAC inhibitors – we were the first to so do in Taiwan,” said Chung Huang, Ph.D., chief executive officer of NatureWise. “This license agreement solidifies our commitment to developing new and innovative drugs for diseases for which no current cures exist.”    

City of Hope’s principal investigator for this patent is Ya-Huei Kuo, Ph.D., an associate professor in the Department of Hematopoietic Stem Cell and Leukemia Research.

About City of Hope
City of Hope is an independent research and treatment center for cancer, diabetes and other life-threatening diseases. Designated as one of only 47 comprehensive cancer centers, the highest recognition bestowed by the National Cancer Institute, City of Hope is also a founding member of the National Comprehensive Cancer Network, with research and treatment protocols that advance care throughout the world. City of Hope is located in Duarte, California, just northeast of Los Angeles, with community clinics throughout Southern California. It is ranked as one of "America's Best Hospitals" in cancer by U.S. News & World Report. Founded in 1913, City of Hope is a pioneer in the fields of bone marrow transplantation, diabetes and numerous breakthrough cancer drugs based on technology developed at the institution. For more information about City of Hope, follow us on Facebook, Twitter, YouTube or Instagram.