NIH awards City of Hope $4.8 million grant to study environment and breast cancer
October 28, 2015
Researchers hope to identify if chemicals in the environment increase risk to develop breast cancer
— The National Institutes of Health
has awarded City of Hope
a five-year, $4.8 million grant to study the possible role of chemicals in the environment in the development of breast cancer during the menopausal transition in women.
The co-principal investigators on the study are two City of Hope researchers known for their work in the potential connection between breast cancer and environmental factors: Shiuan Chen
, Ph.D., professor and chair of the Department of Cancer Biology, and Susan L. Neuhausen
, Ph.D., The Morris & Horowitz Families Professor in Cancer Etiology & Outcomes Research.
City of Hope was among six U.S. institutions to receive a BCERP grant, which funds studies on women’s health issues. The title of the Chen and Neuhausen project is “Menopausal Transition – A Window of Susceptibility for the Promotion of Breast Cancer by Environmental Exposures.”
The study is based on a growing body of evidence supporting the link between environmental factors and breast cancer risk. That evidence suggests there may be specific windows of susceptibility during which a woman’s body is more vulnerable to carcinogenic changes in breast tissue. Breast cancer statistics suggest that one such time of vulnerability could be the menopausal transition, when menstrual periods become less regular and eventually cease.
“We believe that during this time, when natural hormone levels are declining, environmental endocrine-disrupting chemicals promote hormone-responsive breast cancers,” Chen said.
The City of Hope research team will assess the impact that a class of persistent organic pollutants has on estrogen and progesterone receptors in women going through menopause. The goal is to determine whether two types of compounds – bis-phenol A and polybrominated diphenyl ethers – raise breast cancer risk during this time of transition to menopause. To accomplish this, Chen and Neuhausen will evaluate these processes through in vitro cell line experiments, in vivo mouse models, and observational and biological studies in women in the menopausal transition.
The team will analyze blood samples from women who participated in the California Teachers Study
, a cohort of educators followed since 1995 that allows researchers to investigate environmental, genetic, and other factors that may cause cancer.
In addition to evaluating blood samples and publishing outcomes, the City of Hope project includes developing resources for educating and engaging the community about environmental exposures and breast cancer risk.
Other City of Hope investigators participating in the project include: Leslie Bernstein, Ph.D.; Kimlin Tam Ashing, Ph.D.; Noriko Kanaya, Ph.D.; Yuan Chun Ding, Ph.D., M.S.; Xiwei Wu, Ph.D.; Sierra M. Li, Ph.D.; and Timothy Synold, Pharm.D. Additional key researchers are Peggy Reynolds, Ph.D., and David E. Nelson, M.D., M.P.H., of the Cancer Prevention Institute of California
, and Michele Rakoff, a patient and research advocate.
About City of Hope
City of Hope is an independent research and treatment center for cancer, diabetes and other life-threatening diseases. Designated as a comprehensive cancer center, the highest recognition bestowed by the National Cancer Institute, City of Hope is also a founding member of the National Comprehensive Cancer Network, with research and treatment protocols that advance care throughout the nation. City of Hope’s main hospital is located in Duarte, California, just northeast of Los Angeles, with community clinics in southern California. It is ranked as one of "America's Best Hospitals" in cancer by U.S. News & World Report. Founded in 1913, City of Hope is a pioneer in the fields of bone marrow transplantation and genetics. For more information, visit www.cityofhope.org or follow City of Hope on